ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 0970

Influence of Sociodemographic and Clinical Features on Ground Reaction Force Variability Among Individuals with Symptomatic Knee Osteoarthritis: A Novel Computational Approach

Yvonne Golightly1, Siqi Xiang2, Elyse Borgert2, Liubov Arbeeva3, Richard Loeser2, Stephen Messier4, Amanda Nelson5 and J.S. Marron2, 1University of Nebraska Medical Center, Omaha, NE, 2University of North Carolina, Chapel Hill, NC, 3University of North Carolina Chapel Hill, Chapel Hill, NC, 4Wake Forest University, Winston-Salem, NC, 5University of North Carolina at Chapel Hill, Chapel Hill, NC

Meeting: ACR Convergence 2022

Keywords: Biomechanics, gait, Osteoarthritis

  • Tweet
  • Email
  • Print
Session Information

Date: Sunday, November 13, 2022

Title: Research Methodology Poster

Session Type: Poster Session B

Session Time: 9:00AM-10:30AM

Background/Purpose: Abnormally applied forces across the knee during walking play a central role in knee osteoarthritis (OA) disease pathways. Biomechanical data collected continuously during gait analysis are often presented as summary measures (e.g., peak), which overlooks the full range of the data. The purpose of this study was: 1) to identify distinct biomechanical patterns among people with symptomatic knee OA utilizing the full spectrum and richness of gait data, and 2) to examine relationships between the modes of variation of vertical and anterior-posterior (AP) ground reaction force (GRF) curves and baseline sociodemographic and clinical features.

Methods: Data were from the Intensive Diet and Exercise for Arthritis (IDEA) study, a clinical trial of exercise and weight loss among 454 participants with symptomatic knee OA and a body mass index 27-37 kg/m2. Each participant walked over a force plate three times per lower limb (right/left) at their self-selected pace. For analyses, we removed vertical and AP GRF curves that lacked two distinct peaks. We used Angle-based Joint and Individual Variation Explained (AJIVE) to analyze the shared variation between the GRF modes of variation data block and the patient-level features data block, which included measures of sociodemographics, anthropometry, pain, physical function, gait, falls, self-efficacy, physical and mental health, knee OA, inflammatory biomarkers, and comorbid conditions. We visualized the common normalized score (CNS) loadings of the two data blocks using bar plots. We combined the corresponding principal component (PC) scores of each GRF amplitude and phase mode of variation into one data block. We produced two curves visualizing the negative and positive extremes (highest and lowest score for each PC) of all amplitude (curve height) and phase (curve timing) variations used in the GRF PC score data block for vertical and AP GRFs, using the CNS loadings as weights.

Results: The final analysis set included 2,394 curves from 431 participants. The first AJIVE joint component of the GRF PC score data block showed that a faster walking speed was associated with more force upward and downward for the vertical GRF and a faster backward (braking) and forward (propulsion) AP GRF (Figure 1, blue loadings and curves). For the second AJIVE joint component (Figure 2), reduced height of the first and second vertical GRF peaks occurred with a larger body size (weight, BMI, waist and hip circumference, red loadings and curves); no notable differences were observed for the AP GRFs. For the third AJIVE joint component (Figure 3), comorbidities (e.g., diabetes, hypertension) were related to later occurrence of the first peak of vertical GRFs and greater magnitude of AP GRF peaks (blue loadings and curves).

Conclusion: These analyses confirm associations of greater peak vertical and AP GRFs with faster walking speed while also providing new insights into the alterations of GRFs with body size and comorbid conditions. Future analyses will determine how these GRF curve patterns change after the 18-month IDEA study interventions of exercise and weight loss, and how these changes relate to clinical outcomes.

Supporting image 1

Supporting image 2

Supporting image 3


Disclosures: Y. Golightly, None; S. Xiang, None; E. Borgert, None; L. Arbeeva, None; R. Loeser, None; S. Messier, None; A. Nelson, None; J. Marron, None.

To cite this abstract in AMA style:

Golightly Y, Xiang S, Borgert E, Arbeeva L, Loeser R, Messier S, Nelson A, Marron J. Influence of Sociodemographic and Clinical Features on Ground Reaction Force Variability Among Individuals with Symptomatic Knee Osteoarthritis: A Novel Computational Approach [abstract]. Arthritis Rheumatol. 2022; 74 (suppl 9). https://acrabstracts.org/abstract/influence-of-sociodemographic-and-clinical-features-on-ground-reaction-force-variability-among-individuals-with-symptomatic-knee-osteoarthritis-a-novel-computational-approach/. Accessed .
  • Tweet
  • Email
  • Print

« Back to ACR Convergence 2022

ACR Meeting Abstracts - https://acrabstracts.org/abstract/influence-of-sociodemographic-and-clinical-features-on-ground-reaction-force-variability-among-individuals-with-symptomatic-knee-osteoarthritis-a-novel-computational-approach/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology