Increased Risk of Venous Thromboembolism in Adult Patients with Idiopathic Inflammatory Myopathies

Gözde Kübra Yardımcı¹, Arzu Taghiyeva², Enes Erul², Bayram Farisogulları³, Levent Kilic¹ and Sule Apraş Bilgen¹, ¹Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ²HACETTEPE UNIVERSITY, Ankara, Turkey, ³Division of Rheumatology, Department of Internal Medicine Faculty of Medicine, Hacettepe University, Ankara, Turkey

Meeting: ACR Convergence 2021

Keywords: dermatomyositis, Myositis

Session Information

Date: Sunday, November 7, 2021

Title: Muscle Biology, Myositis & Myopathies Poster (0683–0722)

Session Type: Poster Session B

Session Time: 8:30AM-10:30AM

Background/Purpose: Idiopathic inflammatory myopathies (IIMs) patients have a higher risk of venous thromboembolism (VTE) [1]. We aimed to assess the incidence of thrombosis and associated factors in IIMs patients.

Methods: 93 IIMs patients (44 dermatomyositis and 49 polymyositis) were retrospectively reviewed to identify patients who had experienced a thrombosis during the follow-up period. The patients’ clinical characteristics, association with cancer, presence of thrombophilia, APSL autoantibodies, and intravenous immunoglobulin (IVIG) therapy were systematically analysed.

Results: 93 cases with IIMs (64.5% female) were followed median 27.6 (IQR:11.6-75.4) months. The incidence of a thrombotic event in the total cohort was 8.6%. Median time to development of venous thromboembolism was 4 (IQR:1-28,75) months and 75% of the thrombotic events developed during the first year after IIM diagnosis (Table). Venous thromboembolism was not associated with age, sex, cancer or IVIG therapy.

Conclusion: The prevalence of thrombotic events was 8.6% in our cohort and the risk of VTE is highest in the first year of disease. Further studies are needed to identify high-risk patients and to test the role of thromboprophylaxis.

Table: Patients with polymyositis/dermatomyositis and venous thromboembolism

Disclosures: G. Yardımcı, None; A. Taghiyeva, None; E. Erul, None; B. Farisogulları, None; L. Kilic, None; S. Apraş Bilgen, None.

To cite this abstract in AMA style:

Yardımcı G, Taghiyeva A, Erul E, Farisogulları B, Kilic L, Apraş Bilgen S. Increased Risk of Venous Thromboembolism in Adult Patients with Idiopathic Inflammatory Myopathies [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/increased-risk-of-venous-thromboembolism-in-adult-patients-with-idiopathic-inflammatory-myopathies/. Accessed .

« Back to ACR Convergence 2021

ACR Meeting Abstracts - https://acrabstracts.org/abstract/increased-risk-of-venous-thromboembolism-in-adult-patients-with-idiopathic-inflammatory-myopathies/