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Abstract Number: 1317

Impairment of Memory in Axial Spondyloarthritis?

Stefan Kleinert1, Florian Schuch2, Praxedis Rapp2, Monika Ronneberger2, Joerg Wendler2, Patrizia Sternad3, Florian Popp3, Peter Bartz-Bazzanella4, Cay Von der Decken5, Kirsten Karberg6, Georg Gauler7, Patrick Wurth8, Susanna Späthling-Mestekemper9, Christoph Kuhn10, Mathias Englbrecht11, Wolfgang Vorbrüggen12, Georg Adler13 and Martin Welcker14, 1Praxisgemeinschaft Rheumatologie - Nephrologie (PGRN), Erlangen, Germany, 2Praxisgemeinschaft Rheumatologie-Nephrologie, Erlangen, Germany, 3Medizinisches Versorgungszentrum für Rheumatologie Dr. M. Welcker GmbH, Planegg, Germany, 4Rhein-Maas Klinikum, Wuerselen, Germany, 5Klinik für Internistische Rheumatologie, Rhein-Maas-Klinikum, Würselen, Germany, 6Praxis für Rheumatologie und Innere Medizin, Berlin, Germany, Berlin, Germany, 7rheumapraxis, Osnabrck, Germany, 8Rheumatologische Schwerpunktpraxis, Osnabrück, Germany, 9Rheumapraxis München, München, Germany, 10Praxis für Rheumatologie, Karlsruhe, Germany, Karlsruhe, Germany, 11Freelance Healthcare Data Scientist, Eckental, Germany., Eckental, Germany, 12Verein zur Förderung der Rheumatologie e.V., Würselen, Germany, 13Institut für Studien zur Psychischen Gesundheit (ISPG), Mannheim, Germany, 14MVZ für Rheumatologie, Planegg, Germany

Meeting: ACR Convergence 2021

Keywords: Cognitive dysfunction, Psoriatic arthritis, spondyloarthritis

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Session Information

Date: Monday, November 8, 2021

Session Title: Spondyloarthritis Including PsA – Diagnosis, Manifestations, & Outcomes III: Comorbidities, Extra-muskuloskeletal Manifestations, & Related Conditions (1304–1328)

Session Type: Poster Session C

Session Time: 8:30AM-10:30AM

Background/Purpose: There is certain evidence that neuropsychiatric changes occur in systemic lupus(1) and rheumatoid arthritis (2). However, there is little knowledge about possible cognitive changes in axial spondyloarthritis (axSpA). The aim of this study ist to evaluate patients with axial spondyloarthritis regarding cognitive impairments.

Methods: 101 consecutive patients with axial spondyloarthritis attending two rheumatology practices were routinely evaluated by different rheumatologists and underwent a computer-based memory and attention test (MAT) described elsewhere (3, 4). The results of short-term memory and working memory were analyzed compared with an age-, sex- and education-matched control group of healthy subjects.

Results: Patients’ characteristics are displayed in table 1. Patients with axSpA revealed a decreased working memory (table 2) as analysed by Wilcoxon signed-rank test (table 3).

Conclusion: The MAT computerized testing is a highly feasible test and was well accepted by patients. It showed a clinically meaningful decrease in working memory in patients with axial spondyloarthritis. Further work-up is required to characterise possible causes or associations of this cognitive impairment.

Table 1: Patients’ characteristics.

Working Memory and short term memory test results. Patients with spondyloarthritis and an age-, sex, and education-matched controll group.

Wilcoxon signed-rank test revealed a clinically relevant and signficant difference in working memory between patients and controll group.


Disclosures: S. Kleinert, Novartis, 5, Abbvie, 1, Siemens Healthineers, 1, Sanofi, 11; F. Schuch, Abbvie, 1, 6, Novartis, 1, 6, Lilly, 1, Gilead, 1, 6; P. Rapp, None; M. Ronneberger, None; J. Wendler, Janssen Cilag, 1, 6, Roche Pharma, 1, 6; P. Sternad, None; F. Popp, None; P. Bartz-Bazzanella, None; C. Von der Decken, None; K. Karberg, None; G. Gauler, Lilly, 1, Abbvie, 1, 6, Gilead, 6, Novartis, 6; P. Wurth, None; S. Späthling-Mestekemper, None; C. Kuhn, None; M. Englbrecht, None; W. Vorbrüggen, None; G. Adler, None; M. Welcker, Abbvie, 2, 5, 6, Actelion, 5, Aescu, 6, Amgen, 6, Biogen, 6, BMS, 2, 6, Berlin Chemie, 6, Celgene, 2, Galapagos, 2, 5, Gilead, 2, 5, GSK, 2, 5, 6, Hexal, 5, 6, Janssen, 6, Medac, 2, 6, MSD, 6, Mundipharma, 6, Mylan, 2, 6, Novartis, 2, 5, 6, Pfizer, 2, 6, Riemser, 6, Sanofi, 2, 6, UCB, 2, 5, 6.

To cite this abstract in AMA style:

Kleinert S, Schuch F, Rapp P, Ronneberger M, Wendler J, Sternad P, Popp F, Bartz-Bazzanella P, Von der Decken C, Karberg K, Gauler G, Wurth P, Späthling-Mestekemper S, Kuhn C, Englbrecht M, Vorbrüggen W, Adler G, Welcker M. Impairment of Memory in Axial Spondyloarthritis? [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/impairment-of-memory-in-axial-spondyloarthritis/. Accessed January 30, 2023.
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