Background/Purpose: Systemic lupus erythematosus (SLE) is associated with systemic inflammation and heightened cardiovascular risk. However, the impact of SLE on outcomes following percutaneous coronary intervention (PCI) remains understudied. We aimed to evaluate in-hospital outcomes in SLE patients undergoing PCI.

Methods: We performed a retrospective analysis of the National Inpatient Sample from 2016 to 2022, identifying adult patients who underwent PCI. Patients were stratified based on the presence or absence of SLE. Multivariate logistic regression models adjusted for demographics, comorbidities, and hospital characteristics were used to assess outcomes. The primary outcome was in-hospital mortality; secondary outcomes included stroke, atrial fibrillation, heart failure, and bleeding complications.

Results: Of 3,132,560 PCI hospitalizations, 12,765 (0.4%) involved patients with SLE. Compared with non-SLE patients, SLE patients were younger, more likely to be female (78.7% vs 32.5%), and more often Black (23.5% vs 9.6%) (all p < 0.001). SLE patients had a higher prevalence of hypertension, anemia, chronic kidney disease, peripheral arterial disease, and coagulation disorders. There was no significant difference in adjusted in-hospital mortality between groups (OR 0.954, 95% CI 0.856–1.063, p=0.391). However, SLE was associated with higher odds of stroke (OR 1.407, 95% CI 1.348–1.474, p < 0.001), atrial fibrillation (OR 1.078, 95% CI 1.022–1.136, p=0.005), and bleeding complications (OR 1.147, 95% CI 1.051–1.253, p=0.002). No significant difference was observed in the incidence of heart failure.

Conclusion: Among patients undergoing PCI, SLE is associated with increased risks of stroke, atrial fibrillation, and bleeding, but similar in-hospital mortality compared to non-SLE patients. Focused risk mitigation strategies may improve outcomes in this high-risk population.

Table 1. Baseline Characteristics of Patients Undergoing PCI, Stratified by SLE Status

Table 2. Adjusted In-Hospital Outcomes for SLE vs Non-SLE Patients Undergoing PCI

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/impact-of-systemic-lupus-erythematosus-on-in-hospital-outcomes-following-percutaneous-coronary-intervention-insights-from-a-7-year-nationwide-analysis/