ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1099

IgG Autoantibodies Against p29ING4 In Early-Stage Type I Complex Regional Pain Syndrome (CRPS) and In Other Inflammatory Diseases Involving The Joints

Niklas T. Baerlecken1, Torsten Witte2, Reinhold E. Schmidt1, Christina Lansche1, Michael Bernateck3 and Nils Pursche4, 1Clinical Immunology and Rheumatology, Medical University Hannover, Hannover, Germany, 2Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, 3Anesthesiology, Pain Clinic, Medical University of Hannover, Hannover, Germany, 4Clinical Immunology and Rheumatology, Medical University of Hannover, Hannover, Germany

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Title: Fibromyalgia, Soft Tissue Disorders and Pain II

Session Type: Abstract Submissions (ACR)

Background/Purpose:

Complex regional pain syndrome (CRPS, a.k.a. RSD) usually occurs after limb injury, especially fractures of the distal radius and elective hand surgery. Recent research has shown that some patients respond to treatment with immunglobulins supporting an autoimmune pathogenesis of CRPS. There are, however, no diagnostic markers of CRPS.

Methods:

We screened both sera of patients with early-stage type I CRPS and spondyloarthritis (SpA), rheumatoid arthritis (RA), granulomatosis with polyangitis (GPA) for new autoantibodies by using a protein array. Protein-array Human Fetal Brain Cat. Lib. No. 888 was obtained from imagenes biolifesciences (Berlin, Germany,).

In order to study larger numbers of serum samples, we then established ELISA prototypes using the recombinant p29ING4 protein and the synthetic peptides with aminoacid sequence MAAGMYLEHYLDSIENLPFELQRN and DKHIRRLDTDLARFEADLKEK of p29ING4.  For the evaluation of the autoantibodies, we used sera of 36 patients with early-stage type 1 CRPS before starting standard-treatment with glucocorticoids , and as controls of patients with SpA (n=50), RA (n=38), GPA (n=40), and blood donors (BD)(n=96).

Results:

 

CRPS

SpA

RA

GPA

BD

recombinant p29ING4

39%

32%

21%

8%

2%

Aa1-23

28%

28%

45%

5%

2%

Aa94-114

42%

36%

8%

3%

2%

Combining all antigens

75%

62%

53%

8%

7%

Conclusion:

IgG autoantibodies binding to p29ING4 are most frequently in early-stage type I CRPS compared to SpA, RA, GPA and BD supporting the autoimmune pathogenesis of CRPS.

Our findings could help both in the differential diagnosis of different kinds of arthritis and might be an interesting diagnostic marker of CRPS.

Disclosure:

N. T. Baerlecken,
None;

T. Witte,
None;

R. E. Schmidt,
None;

C. Lansche,
None;

M. Bernateck,
None;

N. Pursche,
None.

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