Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: Retinal toxicity from hydroxychloroquine (HCQ), has been recognized for many years. But poor compliance of HCQ might confound results of previous studies. Therefore, we tried to understand HCQ induced retinopathy by investigating association between retinopathy and HCQ serum level.
Methods: 117 patients with HCQ toxicity report and HCQ level measured were included in the analysis. Patients were then followed quarterly since cohort entry. HCQ level were measured at each visit and patients taking HCQ were referred to Ophthalmologists for eye exams.
Results: Among 117 patients, 112 (95.7%) were female. Majority (49.6%) were Caucasian, 44.4% African American. 12 of them have HCQ toxicity confirmed while 7 were possible and majority (83.8%) don’t have HCQ toxicity. Table 1 showed HCQ toxicity in each HCQ group. Table 1: HCQ toxicity in each HCQ group
|Highest HCQ level (ng/mL)||No toxicity N (%)||Possible Toxicity N (%)||confirmed toxicity N (%)||Total|
|Greater than 2,000||25 (83.3)||2 (6.7)||3 (10.0)||30|
|1,500 to 1,999||23 (79.3)||4 (13.8)||2 (6.9)||29|
|1,000 to 1,499||30 (85.7)||1 (2.9)||4 (11.4)||35|
|500 to 999||13 (100)||0 (0)||0 (0)||13|
|Less than 499||7 (70.0)||0 (0)||3 (30.0)||10|
Pair-wise comparison using t test with pooled Standard deviation showed that average highest HCQ levels are not significantly different among three groups (No vs. possible vs. Yes) After grouping people with “confirmed” toxicity and “possible” toxicity together, average highest HCQ level is 1511.632 ng/mL. While highest HCQ level is 1591.051 ng/mL on average among those who didn’t show HCQ toxicity. The difference between these two groups is not significant (P = 0.7094) using t test.
Conclusion: Retinopathy is not associated with highest HCQ level.
To cite this abstract in AMA style:Petri M, Fu W. Hydroxychloroquine Induced Retinopathy in SLE [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/hydroxychloroquine-induced-retinopathy-in-sle/. Accessed July 13, 2020.
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