Hydroxychloroquine Induced Retinopathy in SLE

Michelle Petri¹ and Wei Fu², ¹Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: eye disease and hydroxychloroquine, SLE

Session Information

Date: Sunday, November 13, 2016

Title: Systemic Lupus Erythematosus – Clinical Aspects and Treatment - Poster I: Clinical Trial Design and Current Therapies

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Retinal toxicity from hydroxychloroquine (HCQ), has been recognized for many years. But poor compliance of HCQ might confound results of previous studies. Therefore, we tried to understand HCQ induced retinopathy by investigating association between retinopathy and HCQ serum level.

Methods: 117 patients with HCQ toxicity report and HCQ level measured were included in the analysis. Patients were then followed quarterly since cohort entry. HCQ level were measured at each visit and patients taking HCQ were referred to Ophthalmologists for eye exams.

Results: Among 117 patients, 112 (95.7%) were female. Majority (49.6%) were Caucasian, 44.4% African American. 12 of them have HCQ toxicity confirmed while 7 were possible and majority (83.8%) don’t have HCQ toxicity. Table 1 showed HCQ toxicity in each HCQ group. Table 1: HCQ toxicity in each HCQ group

Highest HCQ level (ng/mL)	No toxicity N (%)	Possible Toxicity N (%)	confirmed toxicity N (%)	Total
Greater than 2,000	25 (83.3)	2 (6.7)	3 (10.0)	30
1,500 to 1,999	23 (79.3)	4 (13.8)	2 (6.9)	29
1,000 to 1,499	30 (85.7)	1 (2.9)	4 (11.4)	35
500 to 999	13 (100)	0 (0)	0 (0)	13
Less than 499	7 (70.0)	0 (0)	3 (30.0)	10

Pair-wise comparison using t test with pooled Standard deviation showed that average highest HCQ levels are not significantly different among three groups (No vs. possible vs. Yes) After grouping people with “confirmed” toxicity and “possible” toxicity together, average highest HCQ level is 1511.632 ng/mL. While highest HCQ level is 1591.051 ng/mL on average among those who didn’t show HCQ toxicity. The difference between these two groups is not significant (P = 0.7094) using t test.

Conclusion: Retinopathy is not associated with highest HCQ level.

Disclosure: M. Petri, None; W. Fu, None.

To cite this abstract in AMA style:

Petri M, Fu W. Hydroxychloroquine Induced Retinopathy in SLE [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/hydroxychloroquine-induced-retinopathy-in-sle/. Accessed .

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