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Abstract Number: 1818

Hepatic Steatosis and Fibrosis in Patients with Gout Detected by Elastography

Naomi Schlesinger1, ankoor patel1, Vinod Rustgi1, Anthony Yeo2 and Peter Lipsky3, 1Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 2Horizontherapeutics, New York, NY, 3AMPEL BioSolutions, Charlottesville, VA

Meeting: ACR Convergence 2022

Keywords: Comorbidity, gout

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Session Information

Date: Monday, November 14, 2022

Title: Metabolic and Crystal Arthropathies – Basic and Clinical Science Poster

Session Type: Poster Session D

Session Time: 1:00PM-3:00PM

Background/Purpose: Gout is associated with non-alcoholic fatty liver disease (NAFLD), but neither the frequency nor severity of NAFLD in gout is well described. Elastography is a well-established ultrasonic method to evaluate both steatosis and fibrosis in the liver but has not been applied to evaluate gout patients.

Methods: We employed the FibroScan, a validated transient elastography method, to evaluate patients with advanced gout at one center from 11/1/2016 – 11/12021. We assessed the Fibrosis score (kPA), which measures liver stiffness (E score), and the controlled attenuation parameter dB/m (CAP) score, which measures steatosis. In addition, we assessed the four-factor fibrosis (FIB-4) Index formula, which combines the patient’s age with aspartate aminotransferase (AST), alanine aminotransferase (ALT), and platelet count.

Results: 47 gout patients (7 females, 14.9%; 40 males, 85.1%) were evauated. The mean age was 59.8 years) and the mean BMI was 30.95 kg/m2. Tophi were present in 11 (26.2% of those with recorded information). Disease duration ranged from 0-49 years. Comorbidities included: dyslipidemia (86.7%), diabetes (31.1%), hypertension (63.6%), CHF (12.8%), CAD (12.8%), chronic kidney disease (19.15%), known liver disease (33.3%) and current alcohol consumption (46.8%). 53.7% (n=29) had hyperuricemia (SU >6.8 mg/dL) and 54.4% had elevations of either ALT or AST.

Hepatic steatosis (CAP >238 dB/m) was found in 40 (85.1%), but was not significantly different in males or females (p=0.37) or those with CHF (p=0.87), CAD (p=0.94), hypertension (p=0.17), diabetes (p=0.68), dyslipidemia (p=0.59) or the presence of known liver diseases (p=0.37). CAP was correlated with BMI (r=0.53, p=0.0001) but not age, serum urate, glucose, triglycerides, ALT, AST, FIB-4, or Fibrosis scores. By Fibroscan, 9 (19.1%) had evidence of fibrosis (E score >7), including one with moderate and 8 with severe fibrosis (cirrhosis). Moderate or severe fibrosis was significantly associated with age (p=0.03), known liver disease (p=0.003), but not ancestry, gender, BMI, triglycerides, HDL, glucose, gout duration, CHF, CAD, hypertension, dyslipidemia, or diabetes. Serum urate was comparable in those with or without moderate or severe fibrosis (p=0.24). The Fib-4 score was significantly greater in those with severe or moderate fibrosis (3.77) versus those with no or mild fibrosis (1.59, p=0.0045). There was a significant correlation between the Fibrosis score and FIB-4 score (r2=0.24, p=0.0009), but not between the Fibrosis score and ALT (p=0.44) or AST(p=0.41).

Conclusion: Hepatic steatosis and fibrosis are common in patients with gout, but not associated with typical gout co-morbidities. Screening for NAFLD with elastography should establish the actual frequency of NAFLD in gout and provide a means to manage this co-morbidity more effectively.


Disclosures: N. Schlesinger, Olatec Therapeutics, Novartis, Horizon Pharma, sobi, JW Pharma, LG Chem; a. patel, None; V. Rustgi, None; A. Yeo, None; P. Lipsky, None.

To cite this abstract in AMA style:

Schlesinger N, patel a, Rustgi V, Yeo A, Lipsky P. Hepatic Steatosis and Fibrosis in Patients with Gout Detected by Elastography [abstract]. Arthritis Rheumatol. 2022; 74 (suppl 9). https://acrabstracts.org/abstract/hepatic-steatosis-and-fibrosis-in-patients-with-gout-detected-by-elastography/. Accessed .
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