ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 0099

First Results of the BELCOMID Study: BELgian Cohort Study of COVID-19 in Immune Mediated Inflammatory Diseases (IMID)

Kurt de Vlam1, Jeroen Geldhof2, Marie Truyens3, Joao Sabino4, Marc ferrante4, Jo Lambert3, Hilde lapeere3, Tom hillary4, an Van Laethem4, Triana Lobaton3, severine vermeire4, Barbara Neerinckx1 and Patrick Verschueren5, 1University Hospitals Leuven, Leuven, Belgium, 2University Hospital Gent, Gent, Belgium, 3university hospital gent, gent, 4university hospitals leuven, leuven, 5University Hospitals Leuven - KULeuven, Leuven, Belgium

Meeting: ACR Convergence 2021

Keywords: , , , ,

Session Information

Date: Saturday, November 6, 2021

Title: Epidemiology & Public Health Poster I: COVID-19 & Vaccination (0084–0117)

Session Type: Poster Session A

Session Time: 8:30AM-10:30AM

Background/Purpose: It has been suggested that 100% of SARS-CoV2 infections leads to development of specific IgG antibodies that remain detectable for a long period of time. Targeted Immune-Modulating Therapies (TIMT) such as anti-TNF, anti-interleukins and Janus Kinase inhibitors (JAKi) for treatment of Immune Mediated Inflammatory diseases (IMID) could theoretically interfere with cytokine storm and humoral immune response against COVID19. We investigate the seroprevalence of SARS-CoV2 IgG in relation to previous exposure to COVID19 and ongoing IMID treatment in a Belgian, real-life population of IMID patients in the prevaccine era.

Methods: A cross-disciplinary, prospective, observational cohort study was set up at two university hospitals. Between 17/12/2020 and 28/02/2021, all patients with IMIDs of the joints (rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, the gut (Crohn’s disease (CD), ulcerative colitis (UC)), and skin (psoriasis, hidradenitis suppurativa, atopic dermatitis) visiting the respective clinics were asked to participate. Both patients under conventional treatment and/or TIMT were included. Patients were asked to fill out an electronic survey (REDCap®, based on WHO-ISARIC) and blood samples were drawn for serology testing (SARS-CoV-2 IgG Abbott – Architect kit®). Statistical analyses were performed with SPSS26.

Results: In total 2166 IMID patients consented to take part. Of these, 1913 responded to the survey, including 415 rheumatology patients, 1217 IBD patients (64.7% CD, 34.3% UC, 1% undifferentiated colitis) and 218 dermatology patients. There were 372 patients (19.5%) who reported having experienced symptoms suggestive of COVID19 (Fig. 1). Fatigue (61.3%), headache (48.1%), sore throat (46.9%) and dry cough (38.7%) were most frequent symptoms. Gastrointestinal symptoms such as diarrhoea or abdominal pain were present in less than 20.0% (Fig. 2). Ninety-six IMID patients (5.04%) had a positive SARS-CoV2 PCR test on nasal or throat swab. In 44/96 (45.8%) anti-SARS-CoV2 IgG seroconversion was confirmed. There was no significant difference in seroconversion rate between patients treated with TIMT compared to conventional therapy (P=0.192). Of the seroconverted group, 75.0% were treated with TIMT. The interval between reported positive PCR date and serology test date ranged from 3 to 24 weeks with a mean of 10 weeks. Of all survey responders, 25 were hospitalized for respiratory symptoms since 01/02/2020, six of these had positive SARS-CoV2 PCR.

Conclusion: Prevalence of COVID19 symptoms and number of confirmed COVID19 cases by PCR in this cohort of IMID patients remain low regardless of treatment modality. There was no significant difference in SARS-CoV2 IgG seroconversion rate between TIMT or conventional treatment in patients with positive PCR.

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Figure 1: number of IMID patients experiencing symptoms suggestive of COVID19 per month

Figure 2: Frequency of experienced symptoms suggestive of COVID19 in IMID patients

Disclosures: K. de Vlam, Amgen, 6, 7, AbbVie, 6, Celgene, 2, 5, 6, Eli Lilly, 2, Johnson & Johnson, 2, Novartis, 2, 6, Galapagos, 2, 7, UCB, 2, 6, 7; J. Geldhof, arena, 1, janssen, 1; M. Truyens, None; J. Sabino, Abbvie, 6, Falk, 6, Takeda, 6, Janssen, 1, Ferring, 2; M. ferrante, Abbvie, 1, 2, 5, 12, Abbvie, Amgen, Biogen, Boehringer-Ingelheim, Celltrion, Falk, Ferring, Janssen, Lamepro, Lilly, Medtronic, MSD, Mylan, Pfizer, Sandoz, Takeda, Thermo Fisher and Truvion Healthcare, Amgen, 5, 6, Biogen, 5, 6, Janssen, 2, 5, 6, Pfizer, 2, 5, 6, Takeda, 2, 5, 6, Boehringer-Ingelheim, 2, 6, Celltrion, 2, Lilly, 2, Medtronic, 2, MSD, 2, 6, Sandoz, 2, 6, Thermo Fisher, 2, Falk, 6, Ferring, 6, Lampero, 6, Mylan, 6, Truvion Healthcare, 6; J. Lambert, UCB, 1, 2, 5, Janssen Pharmaceutica, 1, 2, 5, Novartis, 1, 2, 5, AbbVie, 5; H. lapeere, Leo Pharma, 1, 6, Eli Lilly, 1, Abbvie, 1; T. hillary, Abbvie, 6, Almirall, 6, Amgen, 6, Biogen, 6, Celgene, 6, Janssen, 6, Leo, 6, Eli Lilly, 6, Novartis, 6, Pfizer, 6, Sandoz, 6, Sanofi, 6; a. Van Laethem, Abbvie, 6, Janssen, 6, Falk Pharma, 6; T. Lobaton, Janssen, 2, 5, 6, Takeda, 5, Amgen, 5, 6, Abbvie, 5, Ferring, 5, 6, Mylan, 5, Biogen, 2, 5, Pfizer, 5, Mundipharma, 5; s. vermeire, Abbvie, 1, 2, 5, 6, Pfizer, 1, 2, 5, 6, Takeda, 1, 2, 5, 6, J&J, 1, 2, 5, 6, Biogen, 12, spouse is employee, Genentech/Roche, 2, 6, Galapagos, 1, 2, 5, 6, Celgene, 2; B. Neerinckx, None; P. Verschueren, Pfizer, 12, Holder of the Pfizer Chair Early Rheumatoid Arthritis Management at the KU Leuven, Eli Lilly, 2, Nordic Pharma, 2, galapagos, 2, gilead, 2, ABBVIE, 2, Celltrion, 2, BMS, 2.

To cite this abstract in AMA style:

de Vlam K, Geldhof J, Truyens M, Sabino J, ferrante M, Lambert J, lapeere H, hillary T, Van Laethem a, Lobaton T, vermeire s, Neerinckx B, Verschueren P. First Results of the BELCOMID Study: BELgian Cohort Study of COVID-19 in Immune Mediated Inflammatory Diseases (IMID) [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/first-results-of-the-belcomid-study-belgian-cohort-study-of-covid-19-in-immune-mediated-inflammatory-diseases-imid/. Accessed .

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