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Abstracts tagged "Miscellaneous Rheumatic and Inflammatory Diseases"

  • Abstract Number: 0130 • ACR Convergence 2022

    Three Chinese Pedigrees of A20 Haploinsufficiency

    Yi Tian1, Min Shen2, Bingxuan Wu2, linyi Peng2 and Jian Wang3, 1Rheumatology Department, The Second Affiliated Hospital of Dalian Medical University, Dalian, China, 2Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China, 3Jinzhou City Center for Disease Control and Prevention, Jinzhou, China

    Background/Purpose: Haploinsufficiency of A20 (HA20) is a newly described rare autoinflammatory disease caused by TNFAIP3 gene mutations. HA20 has been seldom documented in the Chinese…
  • Abstract Number: 1751 • ACR Convergence 2022

    Diagnosing the Cardiovascular Risk of VIOXX: A Place for Rofecoxib in Pain Management

    Judith Boice, Mark Corrigan and Bradford Sippy, Tremeau Pharmaceuticals, Inc, Concord, MA

    Background/Purpose: Traditional NSAIDs (tNSAIDs) are effective in treating arthritis pain but can be limited by GI adverse events and general bleeding related to platelet inhibition.…
  • Abstract Number: 0131 • ACR Convergence 2022

    Racial Differences in Bone Health of Sarcoidosis Patients: A Retrospective Study

    Emily Peninger1, Christian Ascoli2, Rachel Lane2, Subash Kukreja2, Robert Baughman3 and Nadera Sweiss2, 1University of Chicago, Chicago, IL, 2University of Illinois at Chicago, Chicago, IL, 3University of Cincinnati, Cincinnati, OH

    Background/Purpose: Bone health in sarcoidosis is a complex topic, though data regarding racial differences in this population is lacking. Our study sought to identify racial…
  • Abstract Number: 1844 • ACR Convergence 2022

    Biological Therapy in Neurosarcoidosis: Study of 30 Patients from a Series of 234 Systemic Sarcoidosis from a University Hospital

    Alba Herrero-Morant1, David Martínez-López2, Lara Sánchez-Bilbao2, iñigo Gonzalez-Mazon2, José Luis Martín-Varillas3, Raúl fernández-ramón2, Carmen Alvarez Reguera2, Miguel Ángel González-Gay4 and Ricardo Blanco5, 1Hospital Universitario Marqués de Valdecilla, Ontinyent, Spain, 2Hospital Universitario Marqués de Valdecilla, Santander, Spain, 3Hospital de Laredo, Laredo, Cantabria, Spain, 4Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, 5Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Neurosarcoidosis (NS) is a severe complication of sarcoidosis. NS may be classified according to several subtypes. Data on therapy, including biological therapy (BT) is…
  • Abstract Number: 0133 • ACR Convergence 2022

    Retention Rate of Targeted Therapies in Erdheim-Chester Disease

    Corrado Campochiaro1, alessandro tomelleri1, Francesco Pegoraro2, Giovanni Galardi3, Nicola Farina4, Martina Mazzariol5, Francesco Catamerò6, Giacomo De Luca4, Giulio Cavalli4, Augusto Vaglio7 and Lorenzo Dagna8, 1IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University, Milano, Italy, 2Department of Health Sciences, University of Florence, Firenze, Italy, 3Department of Health Sciences, University of Florence, Florence, Italy, 4IRCCS San Raffaele Hospital - Vita-Salute San Raffaele University, Milano, Italy, 5University of Turin, Torino, Italy, 6Vita-Salute San Raffaele University, Milano, Italy, 7Azienda Ospedaliero Universitaria Meyer, Parna, Italy, 8IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milano, Italy

    Background/Purpose: Erdheim-Chester disease (ECD) is a rare non-Langerhans histiocytosis with a broad clinical spectrum. The therapeutic landscape of ECD has remarkably changed over the last…
  • Abstract Number: 1845 • ACR Convergence 2022

    Mortality Prognostic Factors of Critically Ill Patients with Systemic Autoimmune Diseases Admitted in a Medical Intensive Care Unit: A 20-year Cohort Study

    Pamela Doti1, Ana Luisa Cunha2, Armin Quispe Cornejo3, Ángela Nieto González1, Andre Matos1, Pedro Guevara Hernández1, Pedro Castro Rebollo1 and Gerard Espinosa Garriga1, 1Hospital Clínic, Barcelona, Spain, 2Hospital Senhora da Oliveira, Guimarães, Porto, Portugal, 3Erasme Hospital, Brussels, Belgium

    Background/Purpose: To describe the clinical characteristics of a 20-year cohort of patients with systemic autoimmune diseases (SAD) admitted to a medical intensive care unit (ICU)…
  • Abstract Number: 0136 • ACR Convergence 2022

    Sarcoidosis Incidence After mTOR Inhibitor Treatment

    Matthew Baker1, Emese Vágó2, Yuhan Liu1, Rong Lu1, Suzanne Tamang3, Erzsébet Horváth-Puhó2 and Henrik Sørensen2, 1Stanford University, Stanford, CA, 2Aarhus University Hospital, Aarhus, Denmark, 3Stanford Center for Population Health Sciences, Redwood City, CA

    Background/Purpose: Mechanistic target of rapamycin (mTOR) inhibitors are effective in animal models of granulomatous disease, but their benefit in patients with sarcoidosis is unknown. We…
  • Abstract Number: 1925 • ACR Convergence 2022

    Characterizing Phenotypic Changes by SARS-CoV-2 Variant in Multisystem Inflammatory Syndrome in Children (MIS-C): A Single Institution Case Series

    Sandy D. Hong1 and Emma Leisinger2, 1University of Iowa Stead Family Children's Hospital, Iowa City, IA, 2University of Iowa, Iowa City, IA

    Background/Purpose: Multisystem inflammatory syndrome in children (MIS-C) is a severe hyper-inflammatory condition associated with a recent SARS-CoV-2 infection. Case reports began in April of 2020…
  • Abstract Number: 0507 • ACR Convergence 2022

    Gut Microbe Metabolite Short-Chain Fatty Acids May Associate with Development of Respiratory Involvement in Patients with Relapsing Polychondritis

    Jun Shimizu1, Masanori Murayama2, Yoshishige Miyabe1 and Noboru Suzuki3, 1St. Marianna University School of Medicine, Kawasaki, Japan, 2Kansai Medical University, Hirakata, Japan, 3St. Marianna University School of Medicine, Kawasaki Kanagawa, Japan

    Background/Purpose: Relapsing polychondritis (RP) is an inflammatory disease that affects cartilaginous tissues of the body and the clinical manifestations and disease courses vary considerably among…
  • Abstract Number: 1942 • ACR Convergence 2022

    Maybe Silent: Spine Disease in Chronic Recurrent Multifocal Osteomyelitis, Clinical Features, Risk Factors, and Red Flags

    Shima Yasin1, T. Shawn Sato2, Emma Leisinger2, Aleksander Lenert2, Yongdong (Dan) Zhao3 and Polly Ferguson1, 1University of Iowa Carver College of Medicine, Iowa City, IA, 2University of Iowa, Iowa City, IA, 3University of Washington, Redmond, WA

    Background/Purpose: Chronic recurrent multifocal osteomyelitis (CRMO) is a female predominant autoinflammatory bone disease. The average age at disease onset is 9-10 years. The majority have…
  • Abstract Number: 0563 • ACR Convergence 2022

    High-Dimensional Immunophenotyping with Mass Cytometry Reveals Unique Immune Cell Aberrations in Patients with Undiagnosed Inflammatory and Autoimmune Diseases

    Alisa Mueller1, Takanori Sasaki2, Joshua Keegan1, Jennifer Nguyen1, Alec Griffith1, Elizabeth Feig1, Alice Horisberger3, Ye Cao1, Gregory Keras1, Lauren Briere4, Laurel Cobban1, Daimon Simmons1, Juan Pallais1, Jeffrey Sparks2, V. Michael Holers5, Undiagnosed Diseases Network1, David Sweetser4, Joel Krier1, Joseph Loscalzo1, James Lederer1 and Deepak Rao1, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Harvard Medical School and Lausanne University Hospital, Boston, MA, 4Massachusetts General Hospital, Boston, MA, 5University of Colorado, Denver, CO

    Background/Purpose: Few tools are available to evaluate the immune dysregulation in patients with severe autoimmune or inflammatory conditions that do not conform to well-defined rheumatologic…
  • Abstract Number: 2243 • ACR Convergence 2022

    Patient Reported Outcomes from a Randomized Phase 3 Trial of Sarilumab in Polymyalgia Rheumatica

    Vibeke Strand1, Jennifer Sloane Lazar2, Michael C Nivens3, Jingdong Chao4, Stefano Fiore5, Angeliki Giannelou6, Lita Araujo7 and Jerome Msihid8, 1Stanford University School of Medicine, Stanford, CA, 2Sanofi, Delray Beach, FL, 3Regeneron Pharmaceuticals, Inc., Tarrytown, NY, NY, 4Regeneron Pharmaceuticals, Inc.,, Tarrytown, NY, 5Sanofi, Bridgewater, NJ, 6Regeneron Pharmaceuticals, Inc., Hoboken, NJ, 7Sanofi, Cambridge, MA, 8Sanofi, Chilly-Mazarin, France

    Background/Purpose: Polymyalgia rheumatica (PMR) is a common inflammatory rheumatic disease in the elderly. The phase 3 SAPHYR trial (NCT03600818) assessed the efficacy and safety of…
  • Abstract Number: 0758 • ACR Convergence 2022

    Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE)-like Syndrome After Immune Checkpoint Inhibition: A CanRIO Study

    Azin Rouhi1, Shahin Jamal2, Marie Hudson3, Janet Pope4, Janet Roberts5, Alexandra Ladouceur3, Sara Hewitt6 and Carrie Ye1, 1University of Alberta, Edmonton, AB, Canada, 2University of British Columbia, Vancouver, BC, Canada, 3McGill University, Montréal, QC, Canada, 4University of Western Ontario, London, ON, Canada, 5Dalhousie University, Halifax, NS, Canada, 6Western University, London, ON, Canada

    Background/Purpose: Immune checkpoint inhibitors (ICI) have shown great promise in the treatment of different malignancies. The use of ICIs has been associated with toxicities that…
  • Abstract Number: 0771 • ACR Convergence 2022

    The Use of a bDMARD or tsDMARD for the Management of Rheumatic irAE Under Checkpoint Inhibitors: An Observational Study

    Fanny De La Fuente1, Rakiba Belkhir2, Julien Henry3, Chi Duc Nguyen4, Thao Pham5, Vincent GERMAIN6, Pierre-Edouard Gavand7, Céline Labadie1, Claire Brière8, Ambre Lauret8, Thierry Cardon9, Gaël Mouterde10, Isabelle Bonnet11, Léa Rouxel12, Marie Truchetet1, Thierry schaeverbeke13, Christophe Richez14 and Marie Kostine15, 1Bordeaux University Hospital, Bordeaux, France, 2Rheumatology departement, Bicêtre, Paris-Saclay university, Le Kremlin Bicêtre, France, 3Department of Rheumatology, University Paris-Saclay, Hospital Bicêtre, Le Plessis Robinson, Ile-de-France, France, 4Bethune Hospital, Bethune, France, 5Aix-Marseille univ, APHM, Marseille, France, 6Pau Hospital, Rheumatology, Pau, France, Pau, France, 7Rhena Clinic, Strasbourg, France, 8Intercommunal Creteil Hospital, Créteil, France, 9Lille University Hospital, Lille, France, 10Lapeyronie Hospital, Montpellier, France, 11University Paris-Saclay, Hospital Bicêtre, Bicêtre, France, 12Arcachon Hospital, Arcachon, France, 13CHU de Bordeaux, Bordeaux, France, 14Université de Bordeaux, Bordeaux, France, 15Pellegrin Hospital, University Hospital of Bordeaux, Rheumatology, Bordeaux, France

    Background/Purpose: Rheumatic immune related adverse events (irAEs) are observed in about 5 to 10% of cancer patients receiving checkpoint inhibitors (ICIs), with inflammatory arthritis (IA)…
  • Abstract Number: 0776 • ACR Convergence 2022

    Expert Clinical Management of Immune-related Inflammatory Arthritis: Results from a Multicenter International Expert Survey

    Sebastian Bruera1, Maria Suarez-Almazor2 and mar Riveiro-Barciela3, 1Baylor College of Medicine, Houston, TX, 2MD Anderson Cancer Center, Houston, TX, 3Hospital Universitari Vall d'Hebron, Barcelona, Spain

    Background/Purpose: The management of inflammatory arthritis related to immune-related adverse events (irAEs) from immune checkpoint inhibitors (ICI) is challenging. Arthritis can become chronic and require…
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ACR Pediatric Rheumatology Symposium 2020

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