Session Information
Date: Tuesday, November 10, 2015
Title: Systemic Sclerosis, Fibrosing Syndromes and Raynaud's - Clinical Aspects and Therapeutics Poster III
Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Pericardial involvement is common in rheumatic disease, as rheumatoid arthritis, lupus erythematosus, mixed connective disease and systemic sclerosis. Few data are available about pathogenesis of pericardial effusion in systemic sclerosis. This study aimed at evaluating the differences in serum levels of adipokines and interleukins (IL) in systemic sclerosis (SSc) patients with and without pericardial effusion.
Methods: A total of 87 outpatients (84 female, mean age of 52,6±14,2 ys, and disease duration of 8,2±6,7 ys), who fulfilled the ACR/EULAR 2013 SSc classification criteria, were recruited in this study. The anthropometric measures, as body mass index (BMI), demographic, clinical and laboratoristic characteristics and SSc related manifestations were assessed in each patient. The presence of pericardial effusion (PE) was evaluated by means of echocardiographic techniques (the presence of fluid ≥ 5 cc was considered pathologic). Sera levels of adiponectin, leptin, resistin, visfatin, tumor necrosis factor α (TNF-α), interferon g (INF-g), IL-2, IL-10 and IL-17 were measured in SSc patients, using Multiplex Immunoassay (Bioplex 200 System), by means of two kits (Bioplex ProTM Cytokine/Chemokine and Growth Factor Assay e Bioplex Pro Diabetes Assay). The data normality was verified using Kolmogorov-Smirnov Test; the comparisons between SSc patients groups were evaluated by Mann-Whitney U test and t-student test, where appropiate. Statistic significance was set at p≤0,05. The results are expressed as median and interquartile range (IQR) or means±1standard deviation. The data analysis were assessed using IBM SPSS statistic 20.
Results: 11 SSc patients had pericardial effusion (PE). The SSc patients groups (with and without PE) did not differ in age (46,5±13,8 ys vs 53,5±14,2 ys), sex and BMI (24,4±5,5 vs 23,62±4,12). 11 SSc patients were obese (BMI≥30) (2 with PE and 9 without PE). We observed significant differences between SSc patients with PE and without PE in sera levels of visfatin (1546,9 (8590,9) vs 388,8 (103); p=0,036), adiponectin (2845000 (4132900,0) vs 5272100,0 (8243600,0); p=0,027) and IL-17 (1,33 (3,5) vs 0,05 (0,56); p=0,45). Moreover higher leptin/adiponectin ratio was found in patients with PE (0,006 (0,01) vs 0,0017 (0,00); p= 0,032). The sera levels of adipokines and IL did not change in SSc patients with interstitial lung disease or pulmonary arterial hypertension, different videocapillaroscopy pattern, limited or diffuse skin subset.
Conclusion: The visfatin and adiponectin could play an important role in pathogetic mechanism in pericardial effusion in systemic sclerosis. Futher study are necessary to unravel a role of visfatin and adiponectin as biomarkers of SSc pathology.
To cite this abstract in AMA style:
Chialà A, Rotondo C, Anelli MG, Praino E, Cantarini L, Scioscia C, Giannini M, Lapadula G, Iannone F. Evaluation of Serum Levels of Adipokines and Interleukines in Pericardial Effusion Related to Systemic Sclerosis [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/evaluation-of-serum-levels-of-adipokines-and-interleukines-in-pericardial-effusion-related-to-systemic-sclerosis/. Accessed .« Back to 2015 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/evaluation-of-serum-levels-of-adipokines-and-interleukines-in-pericardial-effusion-related-to-systemic-sclerosis/