Session Type: Abstract Session
Session Time: 4:00PM-4:50PM
Background/Purpose: To evaluate the efficacy of tocilizumab, an antibody against interleukin-6 receptor (IL-6R), in patients with hand osteoarthritis.
Methods: This was a multicenter, 12-week, randomized, double-blind, placebo-controlled study. Patients with symptomatic hand osteoarthritis (pain ≥ 40 on a 0–100-mm visual analogic scale [VAS] despite analgesics and non-steroidal anti-inflammatory drugs; at least 3 painful joints, Kellgren–Lawrence grade ≥ 2) were randomized to receive two infusions 4 weeks apart (week 0 and week 4) of tocilizumab (8 mg/kg IV) or a placebo. The primary endpoint was the change in VAS pain at week 6. Secondary outcomes included the number of painful and swollen joints, duration of morning stiffness, patients’ and physicians’ global assessment and function scores.
Results: Of 104 patients screened, 91 (82% women; mean age, 64.4 years) were randomly assigned and 79 completed the 12-week study visit. The mean change between baseline and week 6 on VAS pain (primary outcome) was -7.9 (SD 19.4) and -9.9 (SD 20.1) in the tocilizumab and placebo group (p=0.7). No significant treatment differences were observed at weeks 4, 6, 8 or 12 for any secondary outcomes. Overall, adverse events were slightly more frequent in the tocilizumab than placebo group.
Conclusion: Tocilizumab was no more effective than placebo for pain relief in patients with hand osteoarthritis.
To cite this abstract in AMA style:Richette P, Latourte A, Sellam J, Wendling D, Piperno M, Goupille P, Pers Y, Eymard F, Ottaviani S, Ornetti P, Flipo R, Fautrel B, Bertola J, Vicaut E, Chevalier X. Efficacy of Tocilizumab in Patients with Hand Osteoarthritis: Double Blind, Randomized, Placebo Controlled, Multicenter Trial [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/efficacy-of-tocilizumab-in-patients-with-hand-osteoarthritis-double-blind-randomized-placebo-controlled-multicenter-trial/. Accessed April 17, 2021.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/efficacy-of-tocilizumab-in-patients-with-hand-osteoarthritis-double-blind-randomized-placebo-controlled-multicenter-trial/