ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2941

Effect of Achieving Sustained SDAI Remission on Erosion Repair in Patients with Early RA: A Prospective HR-pQCT Study

Jiang Yue1, James F Griffith2, Fan XIAO3, Ling Qin4 and Lai-Shan Tam5, 1Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, HONGKONG, Hong Kong, 3Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 4Bone Quality and Health Centre of the Department of Orthopaedics and Traumatology, The Prince of Wales Hospital, The Chinese University of Hong Kong, hongkong, Hong Kong, 5Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: ,

Session Information

Date: Wednesday, November 8, 2017

Title: Imaging of Rheumatic Diseases II: Focus on Rheumatoid Arthritis and Systemic Sclerosis

Session Type: ACR Concurrent Abstract Session

Session Time: 11:00AM-12:30PM

Background/Purpose:

To assess whether achieving sustained SDAI remission in patients with early rheumatoid arthritis (ERA) facilitates repair of existing bone erosions as measured by high-resolution peripheral quantitative computed tomography (HR-pQCT).

Methods:

In this prospective study, 63 ERA patients were treated with a tight-control protocol aiming at remission using csDMARDs. HR-pQCT examinations were performed at baseline and one-year post-baseline. Changes in erosion size (maximal width, depth, volume) and density of the surrounding bone (marginal osteosclerosis) of erosion near the second metacarpal-phalangeal joint (MCP2) were quantified using HR-pQCT at baseline, 6 months and 12 months. Patients were sub-grouped according to whether or not they achieved sustained simplified disease activity score (SDAI) remission (SDAI< 3.3) at month 6, 9 and 12.

Results:

19 (31%) patients achieved (Group 1) and 44 (69%) patients did not achieve (Group 2) sustained SDAI remission. At baseline, no significant differences in erosion size and marginal osteosclerosis were present between the two groups. In group 1, significant reduction in erosion volume and increase in marginal osteosclerosis was observed between baseline and 12 months (Table 1). In contrast, erosion width significantly increased in group 2 at 6 and 12 months compared to baseline. At 12 months, change in erosion volume was significantly different between the two groups.

Conclusion:

In ERA patients who achieved sustained SDAI remission, HR-pQCT revealed a reduction in erosion volume and an increase in marginal osteosclerosis, indicating that partial erosion repair seems to be possible as long as effective reduction of inflammation is achieved.

Acknowledgement

We would like to acknowledge the Health and Medical Research Fund (HMRF) for funding support (HMRF Project No. 10110071).

Disclosure: J. Yue, None; J. F. Griffith, None; F. XIAO, None; L. Qin, None; L. S. Tam, None.

To cite this abstract in AMA style:

Yue J, Griffith JF, XIAO F, Qin L, Tam LS. Effect of Achieving Sustained SDAI Remission on Erosion Repair in Patients with Early RA: A Prospective HR-pQCT Study [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/effect-of-achieving-sustained-sdai-remission-on-erosion-repair-in-patients-with-early-ra-a-prospective-hr-pqct-study/. Accessed .

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