Does Maastricht Ankylosing Spondylitis Enthesitis Scores Differ between Ankylosing Spondylitis, Psoriatic Arthritis and Rheumatoid Arthritis Patients?

Steffan Robstad Nilssen¹, Jintana B: Andersen¹, Hanne K. Vestaby¹, Glenn Haugeberg² and Brigitte Michelsen³, ¹Dept. of Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ²Martina Hansens Hospital, Bærum, Norway, ³Dept. of Rheumatology, Hospital of Southern Norway Trust, kristiansand, Norway

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Ankylosing spondylitis (AS), Enthesitis, Psoriatic arthritis, rheumatoid arthritis (RA) and spondylarthropathy

Session Information

Date: Tuesday, November 7, 2017

Title: Spondyloarthropathies and Psoriatic Arthritis – Clinical Aspects and Treatment Poster III: Outcomes, Outcome Measures, and Comorbidities

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: The Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) is an enthesitis index developed and validated as an outcome measure in ankylosing spondylitis (AS), but is also commonly used in patients with psoriatic arthritis (PsA). We aimed to compare the MASES scores between AS, PsA and rheumatoid arthritis (RA) patients.

Methods: From January 2016 to April 2017 AS, PsA and RA patients treated with tumour necrosis factor inhibitors (TNFi) were included in a random manner at the outpatient clinic of the Hospital of Southern Norway Trust, Norway. All RA patients fulfilled the ACR/EULAR, the PsA patients the Classification criteria for Psoriatic Arthritis (CASPAR) and the AS patients the Assessment of SpondyloArthritis International Society (ASAS) diagnostic criteria. MASES scores (range 0-13) were measured by a trained nurse. Tenderness was recorded as absent (0) or present (1). The unadjusted analyses of MASES were conducted using a one way analysis of variance (ANOVA) with post hoc tests (Tuckey HSD: homogeneity of variance). The adjusted analyses were conducted using analysis of covariance (ANCOVA) with adjustments for age, sex, disease duration as well as with and without body mass index (BMI). Adjustment for multiple comparisons (Bonferroni) was performed.

Results: A total of 90 AS, 46 PsA and 94 RA patients were included. Mean (SD) age was 48.4 (11.4)/ 54.9 (11.0)/ 54.9 (12.6) years, disease duration 12.6 (9.8) / 14.4 (7.3)/ 13.8 (9.1) years, BMI 27.9 (12.7)/ 27.0 (3.5)/ 26.8 (10.7) kg/m²and percentages females 33.3/ 32.6/ 62.8%, respectively. Both in unadjusted as well as in adjusted analyses, no statistically significant differences in MASES scores between the AS, PsA and RA patients were found (table). Additional adjustment for BMI did not change the main findings.

	AS (n=90)	PsA (n=46)	RA (n=94)	p-value
MASES scores Unadjusted analyses	2.64 (2.00-3.29)	3.44 (2.50-4.37)	2.87 (2.33-3.42)	0.857^a 0.534^b 0.296^c
MASES scores Adjusted analyses	2.91 (2.22-3.60)	3.79 (2.93-4.65)	2.59 (1.92-3.24)	1.000^a
				0.088^b
				0.336^c
Data are shown as mean estimate (95% confidence interval)

a: AS-RA, b: PsA-RA, c: AS-PsA

Conclusion : Enthesitis is a clinically important feature of spondyloarthropathy, in contrast to RA. Nevertheless, no significant differences were found in MASES scores between the RA, PsA and AS patients, even after adjusting for BMI.

Disclosure: S. R. Nilssen, None; J. B. Andersen, None; H. K. Vestaby, None; G. Haugeberg, None; B. Michelsen, None.

To cite this abstract in AMA style:

Nilssen SR, Andersen JB, Vestaby HK, Haugeberg G, Michelsen B. Does Maastricht Ankylosing Spondylitis Enthesitis Scores Differ between Ankylosing Spondylitis, Psoriatic Arthritis and Rheumatoid Arthritis Patients? [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/does-maastricht-ankylosing-spondylitis-enthesitis-scores-differ-between-ankylosing-spondylitis-psoriatic-arthritis-and-rheumatoid-arthritis-patients/. Accessed .

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