ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 0161

Does 18F-FDG-PET/MRI Add Metabolic Information to Anatomic Image in Childhood-onset Takayasu’s Arteritis Patients? A Multicenter Case Series

Gleice Clemente1, Alexandre Souza2, Hilton Leão Filho3, Fernando Coelho3, Carlos Buchpiguel4, Marcos Lima4, Daniela Petry Pioto5, Melissa Fraga1, Ana Paula Sakamoto6, Camila Carneiro4, Rosa Pereira7, Nadia Aikawa7, Clovis Artur Silva7, Lucia Campos8, Camilla Astley9, Bruno Gualano10 and Maria Terreri11, 1Universidade Federal de São Paulo, São Paulo, Brazil, 2UNIFESP-EPM, São Paulo, Brazil, 3Universidade de Sao Paulo/Radiology Institute, São Paulo, Brazil, 4Universidade de São Paulo/Department of Radiology and Oncology, São Paulo, Brazil, 5Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, SP, Brazil, 6Federal University of So Paulo (UNIFESP), São Paulo, Brazil, 7Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 8children's institute, Sao Paulo, Brazil, 9University of Sao Paulo, Sao Paulo, Brazil, 10Universidade de Sao Paulo/Rheumatology Division, São Paulo, Brazil, 11UNIFESP, São Paulo, Brazil

Meeting: ACR Convergence 2021

Keywords: Imaging, kid, Magnetic resonance imaging (MRI), Takayasu.s arteritis, Vasculitis

  • Tweet
  • Email
  • Print
Session Information

Date: Saturday, November 6, 2021

Session Title: Imaging of Rheumatic Diseases Poster (0149–0182)

Session Type: Poster Session A

Session Time: 8:30AM-10:30AM

Background/Purpose: The disease activity assessment in c-TA is a challenge in clinical practice, especially in patients who are under immunosuppression. Our aim was to perform comparison between positron emission tomography (PET) and magnetic resonance angiography (MRA) findings in childhood-onset Takayasu’s arteritis (c-TA) patients.

Methods: A three-center cross-sectional study with 17 children and adolescents who fulfilled the EULAR/PRINTO/PReS criteria for c-TA was conducted. The patients underwent 18F-FDG-PET/MRI imaging (SIGMATM PET/MR, GE Healthcare, Milwakee-MI, USA). Positive MRA consisted of arterial wall thickening with contrast-enhancement, whereas positive PET was defined as arterial wall uptake higher than the normal liver degree of FDG uptake. Patients were divided in three groups according to the different combinations of imaging findings as following: group 1 (PET+MRA+), group 2 (PET+MRA-) and group 3 (PET-MRA+).

Results: Seventeen c-TA patients (65% female) were included. Mean disease duration was nine ±3.6 years. PET identified high-grade 18F-FDG arterial wall uptake in 15 (88.2%) patients and MRA detected thickening with contrast-enhancement in 10 (58.8%). Nine patients were classified as group 1, six as group 2 and 1 as group 3. One patient had no vessel-wall changes in both images. Median of metabolic inflammatory volume (MIV) value was significantly higher in group 1 compared to group 2 (2346 vs. 1177 cm3; p=0.036) (Table 1). Fifty-four (19%) from 284 available arterial segments presented vessel-wall changes in one or both imaging. Positive PET was found in 35 (12.3%) and positive MRA in 26 (9.2%) vessels (Table 2). Positive findings in vessel-wall were concordant between PET and MRA exams in seven (2.5%) and were not concordant in 47 (16.5%) arterial segments.

Conclusion: Our study demonstrated that 18F-FDG-PET/MRI is a new exam that adds metabolic information to anatomic image in c-TA patients, and may help therapeutic decision, especially for those during immunosuppressive withdrawal.

Table 1 – Clinical, laboratorial, treatment data and PET findings in group 1 and 2 in c-TA patients.
c-TA: childhood-onset Takayasu’s arteritis; ESR: erythrocyte sedimentation rate; CRP: C reactive protein; PET: positron emission tomography; MRA: magnetic resonance angiography; SUVmax: maximum standardized uptake value; MIV: metabolic inflammatory volume. Numerical values are presented in median (IQR). *1 patient had no vessel wall changes in MRA or PET imaging and 1 patient had vessel-wall changes in MRA but no vessel-wall changes in PET.

Table 2 – PET and MRA findings according to each arterial segment (N=284) in c-TA patients
c-TA: childhood-onset Takayasu’s arteritis; PET: positron emission tomography; MRA: magnetic resonance angiography; VS: visual score; T+E: thickening + enhancement; RCC: right common carotid; LCC: left common carotid * Vessel-wall changes in PET and MRA that have undergone surgical intervention (5 arterial segments) were not considered.


Disclosures: G. Clemente, None; A. Souza, None; H. Leão Filho, None; F. Coelho, None; C. Buchpiguel, None; M. Lima, None; D. Pioto, None; M. Fraga, None; A. Sakamoto, None; C. Carneiro, None; R. Pereira, None; N. Aikawa, None; C. Silva, None; L. Campos, None; C. Astley, None; B. Gualano, None; M. Terreri, Sanofi, 6, Alexion, 6, Pfizer, 6, Novartis, 6, Abbvie, 6, Roche, 6, Biomarin, 6, GSK, 6, Jansen, 12, Clinical studies, UCB, 12, Clinical studies, Bristol, 12, Clinical studies, Lilly, 12, Clinical studies.

To cite this abstract in AMA style:

Clemente G, Souza A, Leão Filho H, Coelho F, Buchpiguel C, Lima M, Pioto D, Fraga M, Sakamoto A, Carneiro C, Pereira R, Aikawa N, Silva C, Campos L, Astley C, Gualano B, Terreri M. Does 18F-FDG-PET/MRI Add Metabolic Information to Anatomic Image in Childhood-onset Takayasu’s Arteritis Patients? A Multicenter Case Series [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/does-18f-fdg-pet-mri-add-metabolic-information-to-anatomic-image-in-childhood-onset-takayasus-arteritis-patients-a-multicenter-case-series/. Accessed January 27, 2023.
  • Tweet
  • Email
  • Print

« Back to ACR Convergence 2021

ACR Meeting Abstracts - https://acrabstracts.org/abstract/does-18f-fdg-pet-mri-add-metabolic-information-to-anatomic-image-in-childhood-onset-takayasus-arteritis-patients-a-multicenter-case-series/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2023 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences