Session Type: Abstract Submissions (ACR)
To perform a comparative study concerning clinical characteristics and treatment between Sudanese and Swedish RA outpatients.
A 286 Sudanese and 542 Swedish RA outpatients diagnosed according to 1987 ACR classification criteria were recruited between December 2008 and September 2010 and compared concerning clinical presentation, treatment and laboratory findings including IgM RF.
Age at inclusion, disease duration and median age at disease onset were all significantly lower among the Sudanese patients (p <0.0001). When stratified concerning age of inclusion, Swedish patients between 41-50 years had however a significantly lower age of onset, with a similar trend for all age groups above 30 years. Levels of ESR and number of affected joints were significantly higher among Sudanese RA patients. The proportion of IgM RF positivity was significantly lower among Sudanese RA patients (p<0.0001). Higher proportions of Sudanese RA patients were treated with methotrexate and DMARD combinations but none of them on biologics. Sudanese patient used lower doses of methotrexate and sulfasalazine (p <0.0001) and higher doses of prednisolone (p <0.0001) than Swedish patients. The female preponderance was more striking among Sudanese patients (p <0.0001), although smoking was non-existent among the Sudanese female RA patients (p<0.0001).
Sudanese RA patients have significantly higher disease activity and are often IgM RF seronegative. Together with reports from Uganda and Cameroon our data indicate a cluster of highly active seronegative RA in central Africa.
A. D Elkhalifa,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/disease-severity-and-treatment-of-rheumatoid-arthritis-a-comparative-study-between-sudan-and-sweden/