Disease Duration, Age and Clinical Features Related to Aortic Valve Sclerosis in Patients with Spondyloarthritis

Asier García-Alija¹, Hye Sang Park¹, Patricia Moya¹, Ana Laiz¹, Carla Marco², Albert Casals¹, Concepcion Pitarch², Cesar Diaz-Torné¹, Berta Paula Magallares³, Ivan Castellvi Barranco¹, Susana Fernández-Sánchez¹, Andrea García-Guillen², Jose Luis Tandaipan¹, Helena Codes-Mendez¹, Guillem Verdaguer¹, Luis Sainz¹ and Hèctor Corominas¹, ¹Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ²Hospital Dos de Maig, Barcelona, Spain, ³Dept of Rheumatology, Hospital de la Santa Creu I Sant Pau, Barcelona, ES, Barcelona, Spain

Meeting: ACR Convergence 2024

Keywords: Epidemiology, Heart disease, spondyloarthritis

Session Information

Date: Saturday, November 16, 2024

Title: SpA Including PsA – Diagnosis, Manifestations, & Outcomes Poster I

Session Type: Poster Session A

Session Time: 10:30AM-12:30PM

Background/Purpose: Valve degeneration is prevalent in Spondylarthritis (SpA) patients according to descriptive studies, but it is also common in general population. Disease burden may be a key factor for valve degeneration in SpA.

The purpose of the study was to compare clinical, radiographic and laboratory parameters between patients with spondylarthritis (SpA) with aortic valve sclerosis (AVS) and compare disease duration since onset of symptoms, diagnosis, and age in patients with AVS and patients without AVS.

Methods: A retrospective cohort study was conducted. Eligible patients were 219 SpA patients that met ASAS criteria visited the SpA clinic between July – October 2022. A total of 75 patients that had an echocardiography carried out after SpA diagnosis were included. Aortic valve surgery, rheumatic valve disease, endocarditis and bicuspid valves were excluded. Missing information about SpA were collected prospectively. Comparison between groups was conducted using t test or U-Mann Whitney test according to variable distribution. Proportions were compared using risk difference (RD) or odds ratio (OR).

Results: AVS was observed in 30 (39.5%) patients. Description and comparison of the sample is summarized in table 1. Age had an OR of 1.17 (95% CI 1.1-1.3) with minor increase of risk for AVS. Duration of disease and delay in diagnosis were similar in both groups. Smoking had a protective effect for AVS with OR former smoker 0.36 (95% CI 0.12-1.11) and OR smokers 0.13 (95% CI 0.03-0.61).

Other echocardiographic findings of the patients were: mild aortic insufficiency in 15 (19.5%) and moderate in 3 (3.9%). Mean aortic root diameter was 34.4mm (SD 3.67). Aortic root was dilated in 9 (11.7%).

Conclusion: Age showed small but statistically significant association with AVS. Disease duration measured since diagnosis or onset of 1st symptom did not show significant association. Surprisingly, smokers showed less AVS.

Disclosures: A. García-Alija: None; H. Park: None; P. Moya: None; A. Laiz: None; C. Marco: None; A. Casals: None; C. Pitarch: None; C. Diaz-Torné: None; B. Paula Magallares: None; I. Castellvi Barranco: None; S. Fernández-Sánchez: None; A. García-Guillen: None; J. Tandaipan: None; H. Codes-Mendez: None; G. Verdaguer: None; L. Sainz: None; H. Corominas: None.

To cite this abstract in AMA style:

García-Alija A, Park H, Moya P, Laiz A, Marco C, Casals A, Pitarch C, Diaz-Torné C, Paula Magallares B, Castellvi Barranco I, Fernández-Sánchez S, García-Guillen A, Tandaipan J, Codes-Mendez H, Verdaguer G, Sainz L, Corominas H. Disease Duration, Age and Clinical Features Related to Aortic Valve Sclerosis in Patients with Spondyloarthritis [abstract]. Arthritis Rheumatol. 2024; 76 (suppl 9). https://acrabstracts.org/abstract/disease-duration-age-and-clinical-features-related-to-aortic-valve-sclerosis-in-patients-with-spondyloarthritis/. Accessed .

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