ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 213

Digital Tomosynthesis for Measurement of Bone Erosion in Gout: Comparison With Computed Tomography

Nicola Dalbeth1, Anthony Doyle2, Mark Roger3, Angela Gao4 and Fiona M. McQueen5, 1Medicine, University of Auckland, Auckland, New Zealand, 2University of Auckland, Auckland, New Zealand, 3Department of Radiology, Auckland District Health Board, Auckland, New Zealand, 4Radiology, Auckland District Health Board, Auckland, New Zealand, 5Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: Bone, Computed tomography (CT), gout, imaging techniques and radiography

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Title: Imaging of Rheumatic Diseases I: Imaging in Gout, Pediatric, Soft and Connective Tissue Diseases

Session Type: Abstract Submissions (ACR)

Background/Purpose: Digital tomosynthesis is a recently developed imaging method in which multiple projected images obtained at different angles are collected with a digital detector. These projected images are used to reconstruct multiple thin planar images of the scanned object in a plane parallel to the detector.  Recent reports indicate that this technology allows low-cost, low-radiation detection of bone erosion in patients with inflammatory arthritis.  The aim of this study was to determine the sensitivity and reproducibility of tomosynthesis, compared with conventional computed tomography (CT), for measurement of bone erosion in gout.

Methods: Tomosynthesis and CT scans of the dominant wrist were prospectively obtained in 37 patients with gout (mean disease duration 18 years, 86% with subcutaneous tophi) (Figure). Each scan was scored separately by two radiologists for bone erosion using semi-quantitative volume assessment (sites and 0-10 scoring as for RAMRIS erosion method).

Results: The mean total erosion score in the tomosynthesis scans was lower than CT scans (10.8 vs 13.2, p=0.004).  For many individual sites (radius, scaphoid, triquetrum, trapezium, capitate, MC1 base), tomosynthesis erosion scores were significantly lower than CT scores.  There were no sites where tomosynthesis scores were higher than CT.  The inter-reader intraclass correlation coefficients (ICC) for the total erosion score was 0.64 (0.59-0.89) for tomosynthesis and 0.80 (0.64-0.94) for CT. At all individual sites except MC2 base, ICCs were lower for tomosynthesis than CT.  We were unable to identify a combination of sites for which mean scores or ICCs for tomosynthesis approximated those of CT.  There was a high correlation between tomosynthesis and CT total scores (r=0.95, p<0.0001) and at most individual sites. Total erosion scores for both tomosynthesis and CT correlated highly with hand tophus count, grip strength, and Health Assessment Questionnaire scores (p<0.001 for all). 

Conclusion: Tomosynthesis erosion scores correlate highly with CT erosion scores and clinical measures of disease severity in patients with gout.  However, tomosynthesis has lower reproducibility and detection of erosion compared with CT.  These findings indicate that CT remains the gold standard for measurement of bone erosion in gout.

Figure: A. Tomosynthesis and B. corresponding coronal CT images of the right wrist in a participant with tophaceous gout.

Figure ACR abstract


Disclosure:

N. Dalbeth,
None;

A. Doyle,
None;

M. Roger,
None;

A. Gao,
None;

F. M. McQueen,
None.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2013 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/digital-tomosynthesis-for-measurement-of-bone-erosion-in-gout-comparison-with-computed-tomography/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology