Diagnostic Accuracies of Sialography and Salivary Ultrasonography in Sjogren’s Syndrome Patients: A Meta-Analysis

Young Ho Lee¹ and Gwan Gyu Song², ¹Internal Medicine, Rheumatology, Korea University Medical Center, Seoul, South Korea, ²Div of Rheum, Dept of Int Medicine, Guro Hospital, Korea Univ College of Medicine, Seoul, South Korea

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: meta-analysis, salivary gland and ultrasonography, Sjogren's syndrome

Session Information

Title: Sjogren's Syndrome: Clinical Science

Session Type: Abstract Submissions (ACR)

Background/Purpose

Ultrasonography (US) may come to replace conventional invasive examinations in clinical practice. However, the diagnostic accuracy of salivary US has not been clearly compared with sialography, and there is as of yet no consensus on the use of US as an alternative method for the assessment of salivary gland involvement in Sjogren’s syndrome (SS) patients. Salivary US been studied in the context of SS in comparison with sialography with respect to diagnostic accuracy. However, published results on the diagnostic accuracies of sialography and US are controversial and inconclusive. This may be due to small sample sizes, low statistical power, and/or clinical heterogeneity. The purpose of this study was to compare the diagnostic performance of sialography and salivary ultrasonography (US) for Sjogren’s syndrome (SS) patients.

Methods

We searched Medline, Embase, and the Cochran library, and performed two meta-analyses on the diagnostic accuracy of sialography and salivary US in SS patients.

Results

A total of six studies including 488 patients and 447 controls from two European and four Asian studies were available for the meta-analysis. The pooled sensitivity and specificity of sialography were 80.0% (95% confidence interval [CI] 76.4-83.2) and 89.0% (85.8-91.8), respectively, and 77.4 (73.7-80.9) and 81.5 (77.6-85.0) for US, respectively. For sialography, the PLR, NLR, and DOR were 9.296 (4.200-20.57), 0.228 (0.170-0.305), and 46.51 (16.14-134.0), respectively, and for US were 4.631 (2.707-7.864), 0.302 (0.226-0.403), and 17.48 (10.03-30.45), respectively. The area under the curve (AUC) of sialography was 0.824, and the Q^* index was 0.757, while the AUC of US was 0.864, and its Q^* index was 0.794, indicating that the diagnostic accuracy of US is comparable with sialography in SS patients. A subgroup meta-analysis according to the diagnostic criteria did not change the overall diagnostic accuracy.

Conclusion

Our meta-analysis of published studies demonstrates that the diagnostic accuracy of salivary US is comparable with sialography in SS patients.

Disclosure:

Y. H. Lee,
None;

G. G. Song,
None.

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/diagnostic-accuracies-of-sialography-and-salivary-ultrasonography-in-sjogrens-syndrome-patients-a-meta-analysis/