ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 0890

Depression Is Associated with Frailty in Systemic Lupus Erythematosus Patients: Multicenter Retrospective Analysis Using Systemic Lupus Erythematosus International Collaborating Clinics-Frailty Index

Kichul Shin1, In Ah Choi2, Eunyoung Lee3, SE RIM CHOI4, Jina Yeo5, Yun Jong Lee6, Su-Jin Yoo7, Bong-Jin Hahm4, Jee Eun Park4, Ju Ho Lee8, Yeong-Wook Song4 and Ju Yeon Kim4, 1Seoul Metropolitan Government- Seoul National University Boramae Medical Center, Seoul, Republic of Korea, 2Chungbuk National University Hospital, Cheongju, Republic of Korea, 3Uijeongbu Eulji Medical Center, Seoul, South Korea, 4Seoul National University Hospital, Seoul, Republic of Korea, 5Gil Medical Center, Seoul, South Korea, 6Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea, 7Chungnam National University Hospital, Daejeon, Republic of Korea, 8Seoul National University Bundang Hospital, Yongin Si, Republic of Korea

Meeting: ACR Convergence 2021

Keywords: , , , ,

Session Information

Date: Sunday, November 7, 2021

Title: SLE – Diagnosis, Manifestations, & Outcomes Poster II: Manifestations (0855–0896)

Session Type: Poster Session B

Session Time: 8:30AM-10:30AM

Background/Purpose: Systemic Lupus Erythematosus International Collaborating Clinics-Frailty Index (SLICC-FI) is a novel health measure in systemic lupus erythematosus (SLE) and was reported to have impact on outcomes including mortality. The objective of the study was to evaluate the association of depression and frailty in SLE patients.

Methods: SLE patients who fulfilled 1997 American College of Rheumatology (ACR) classification criteria were enrolled from five teaching hospitals in Korea and the participants filled out questionnaires at outpatient clinic. Electronic medical records were reviewed for laboratory results, disease activity at enrollment, medications and damage index score and SLICC-FI was calculated. To assess the severity of depression, patient health questionnaire-9 (PHQ-9) was used. Logistic regression analysis was used to evaluate the factors associated with frailty in SLE patients

Results: In total, 247 patients were recruited. Mean (standard deviation, SD) age of the cohort was 50.5 (1.6) and 91.9% of the cohort was female. The mean (SD) of SLE disease activity index-2000 (SLEDAI-2K) was 3.5 (4.0). According to SLICC-FI, 36 (14.6%) patients were classified as frail. Mild depression (PHQ-9 score ≥ 5) was observed in 97.2% of frail patients and 54.5% of not-frail patients. Severe depression (PHQ-9 ≥ 20) was observed in 22.2% of frail patients and 1.4% of not-frail patients. In multivariable logistic regression analysis, age (1.09), ESR (1.03), SLEDAI-2K (1.18), PHQ-9 score (1.27) and SLICC/ACR damage index (3.22) were associated with frailty (odds ratio in parenthesis).

Conclusion: Depression in SLE patients was associated with frailty. Rheumatologists should pay attention to early detection and intervention of depression in SLE patients to improve outcomes.

Table 1

Disclosures: K. Shin, None; I. Choi, None; E. Lee, None; S. CHOI, None; J. Yeo, None; Y. Lee, None; S. Yoo, None; B. Hahm, None; J. Park, None; J. Lee, None; Y. Song, None; J. Kim, None.

To cite this abstract in AMA style:

Shin K, Choi I, Lee E, CHOI S, Yeo J, Lee Y, Yoo S, Hahm B, Park J, Lee J, Song Y, Kim J. Depression Is Associated with Frailty in Systemic Lupus Erythematosus Patients: Multicenter Retrospective Analysis Using Systemic Lupus Erythematosus International Collaborating Clinics-Frailty Index [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/depression-is-associated-with-frailty-in-systemic-lupus-erythematosus-patients-multicenter-retrospective-analysis-using-systemic-lupus-erythematosus-international-collaborating-clinics-frailty-index/. Accessed .

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/depression-is-associated-with-frailty-in-systemic-lupus-erythematosus-patients-multicenter-retrospective-analysis-using-systemic-lupus-erythematosus-international-collaborating-clinics-frailty-index/