ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 0474

Correlation of Fibromyalgia Survey Questionnaire and Quantitative Sensory Testing Among Patients with Active Rheumatoid Arthritis

Meriah Moore1, Beth Wallace2, Jing Song3, Lutfiyya Muhammad4, Andrew Heisler5, Daniel Clauw1, Marcy Bolster6, Wendy Marder1, Tuhina Neogi7, Alyssa Wohlfahrt8, Dorothy Dunlop9 and Yvonne Lee9, 1University of Michigan, Ann Arbor, MI, 2Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, 3Northwestern University, Worthington, IL, 4Northwestern University Feinberg School of Medicine, Chicago, IL, 5Bronson Rheumatology Specialists, Kalamazoo, MI, 6Massachusetts General Hospital, Boston, MA, 7Boston University School of Medicine, Boston, MA, 8Tufts University School of Medicine, Boston, MA, 9Northwestern University, Chicago, IL

Meeting: ACR Convergence 2021

Keywords: , , ,

Session Information

Date: Saturday, November 6, 2021

Title: Abstracts: Fibromyalgia & Other Clinical Pain Syndromes (0474–0477)

Session Type: Abstract Session

Session Time: 11:00AM-11:15AM

Background/Purpose: Patients with rheumatoid arthritis (RA) commonly demonstrate disordered pain processing, termed central sensitization (CS). CS is typically measured using quantitative sensory testing (QST), which is burdensome to patients. The self-administered fibromyalgia survey questionnaire (FSQ) has been proposed as a low-burden surrogate measure of CS. We examine the correlation between FSQ and QST in a population with active RA.

Methods: RA patients in the multicenter Central Pain in Rheumatoid Arthritis cohort underwent FSQ and QST evaluation at enrollment. QST measures included pressure pain threshold (PPT) at thumb, trapezius, wrist and knee, temporal summation (TS) at wrist and arm, and conditioned pain modulation (CPM). Spearman correlation was assessed between FSQ and each QST measure, adjusted for age, sex, race, body mass index, sero-status, swollen joint count, C-reactive protein, pain catastrophizing, and study site. We performed sensitivity analyses stratified by a) patient sex and b) sub-components of the FSQ (widespread pain index [WPI], and symptom severity scale [SSS]).

Results: Among 285 RA patients with high RA activity (mean baseline Clinical Disease Activity Index score of 24.56), FSQ was weakly but statistically significantly correlated with PPT (r = -0.21 to -0.31), and TS (r = 0.13 to 0.15) at all sites in unadjusted analyses (Figure 1). After adjustment for the covariates above, statistically significant correlations persisted for PPT at all sites except the thumb, and for TS at the wrist. Sensitivity analyses did not identify any differences in association based on sex or differences in associations with the components of the FSQ (WPI or SSS).

Conclusion: FSQ and QST were correlated among patients with active RA, but the strength of association was weak. These results do not support the use of FSQ as a proxy measurement for QST-assessed central sensitization among patients with active RA.

Figure 1: Unadjusted and adjusted correlations between QST measures and FSQ.

Adjusted for age, sex, race, BMI, seropositivity, swollen joint count, CRP, pain catastrophizing, and site. PPT = pressure pain threshold; TS = temporal summation; CPM = conditioned pain modulation.

Disclosures: M. Moore, None; B. Wallace, None; J. Song, None; L. Muhammad, None; A. Heisler, None; D. Clauw, Pfizer, 2, 6, Aptinyx, 2, Daiichi, 2, Sankyo, 2, Eli Lilly, 2, 6, Intec Pharma, 2, Samumed, 2, Theravance, 2, Tonix, 2, Zynerba, 2, Nix Patterson LLP, 6, Williams & Connolly LLP, 6; M. Bolster, Johnson and Johnson, 11, Genentech, 5, Corbus, 5, Cumberland, 5, PracticeUpdate, 12, Associate Editor, Custom Learning Designs, 2; W. Marder, None; T. Neogi, Pfizer/Lilly, 2, Regeneron, 2, Novartis, 2; A. Wohlfahrt, None; D. Dunlop, None; Y. Lee, Eli Lilly, 2, 6, Pfizer, 5, Cigna, 11.

To cite this abstract in AMA style:

Moore M, Wallace B, Song J, Muhammad L, Heisler A, Clauw D, Bolster M, Marder W, Neogi T, Wohlfahrt A, Dunlop D, Lee Y. Correlation of Fibromyalgia Survey Questionnaire and Quantitative Sensory Testing Among Patients with Active Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/correlation-of-fibromyalgia-survey-questionnaire-and-quantitative-sensory-testing-among-patients-with-active-rheumatoid-arthritis/. Accessed .

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