Background/Purpose: Gout is associated with several comorbidities. The aim of this study was to evaluate the prevalence of comorbidities in Korean adult population with gout.

Methods: Data from 15,935 (weighted n = 39,049,167) participants aged 19 years and older in the Korean National Health and Nutrition Examination Survey from 2019 to 2021 was used for analysis. Weighted prevalence and odds ratios (OR) of comorbidities in individuals with gout were compared with the non-gout population.

Results: The weighted prevalence of gout was 2.1% (weighted n = 808,778). Among individuals with gout, 66.5% had metabolic syndrome, 46.2% had hypertension, 35.6% had dyslipidemia, 19.2% had diabetes, 13.5% had chronic kidney disease (eGFR < 60), 4.1% had myocardial infarction or angina, 3.8% had stroke, and 2.8% hand rheumatoid arthritis. After adjusting for socioeconomic and lifestyle characteristics, gout was independently associated with increased prevalence of metabolic syndrome (male OR 2.0, 95% CI, 1.5-2.8; female OR 3.7, 95% CI 1.5-9.2), hypertension (male OR 2.7, 95% CI 1.9-3.7; female OR 2.5, 95% CI 1.4-4.5), dyslipidemia (male OR 2.0, 95% CI 1.5-2.7; female OR 3.8, 95% CI 1.5-10.0), chronic kidney disease (male OR 4.5, 95% CI 2.7-7.3; female OR 16.2, 95% CI 7.5-34.9), and rheumatoid arthritis (male OR 2.8, 95% CI 1.1-7.1; female OR 3.1, 95% CI 1.1-8.7) compared to the non-gout population.

Conclusion: Gout was associated with several medical comorbidities and rheumatoid arthritis in both males and females. These results suggest that clinicians should prioritize the prevention and management of underlying comorbidities in patients with gout.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/comorbidities-of-gout-results-from-the-korean-national-health-and-nutrition-examination-survey/