Session Type: Poster Session D
Session Time: 9:00AM-11:00AM
Background/Purpose: A retrospective analysis of the Hopkins Lupus Cohort (a prospective, longitudinal study of patients [pts] with systemic lupus erythematosus) reported that renal response (complete/partial/none) at 24 months post-diagnosis of lupus nephritis (LN) predicts long-term renal survival.1 Here, we compare long-term renal survival and chronic renal insufficiency-free survival in pts with and without a renal response (RR) to standard LN therapy, as defined by primary endpoint in the Phase 3 BLISS-LN study (GSK Study BEL114054; NCT01639339).
Methods: This retrospective analysis (GSK Study 213039) of the Hopkins Lupus Cohort included pts with biopsy-proven class III, IV, or V LN. Endpoints were: long-term renal survival (no end-stage renal disease [ESRD] and/or mortality) and long-term chronic renal insufficiency-free survival by RR status at 24 months post-biopsy, both assessed by Kaplan−Meier plots with log-rank test and Cox proportional hazards regression.
Results: 173 pts with LN were included; 91.3% were female and mean (SD) age at biopsy was 36.2 (11.8) years. At 24 months post-biopsy, 114 (65.9%) pts achieved RR. Pts with RR at 24 months were less likely to experience an ESRD/mortality event and chronic renal insufficiency (Figure), even after adjusting for covariates (HR [95% CI] 0.33 [0.13, 0.87], p=0.0255; and HR [95% CI] 0.26 [0.14, 0.47], p< 0.0001, respectively).
Conclusion: Achieving BLISS-LN primary endpoint defined RR at 24 months post-biopsy is associated with long-term renal survival and chronic renal insufficiency-free survival in pts with LN.
Prior presentation: Submitted to ASN 2020. If accepted (notifications due August 7), to be presented at Kidney Week 2020 from October 20, 2020 – October 25, 2020 and published in the ASN Abstract Supplement PDF, which will be posted online by October 9, 2020.
Reference: 1. Davidson JE, et al. J Rheumatol 2018;45(5):671–7.
To cite this abstract in AMA style:Petri M, Fu Q, Green Y, Madan A, Goldman D, Cooper-Blenkinsopp S. Clinical Outcomes in Lupus Nephritis by Renal Response Status: A Retrospective Analysis of the Hopkins Lupus Cohort [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/clinical-outcomes-in-lupus-nephritis-by-renal-response-status-a-retrospective-analysis-of-the-hopkins-lupus-cohort/. Accessed November 26, 2020.
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