Clinical Characteristics of Spondyloarthritis Patients in Japan in Comparison to Other Regions of the World

Haruki Sawada¹, Kazuki Yoshida², Naomi Ichikawa³, Hisashi Inoue⁴, Yuko Kaneko⁵, Taku Kawasaki⁶, Kazuo Matsui⁷, Mitsuhiro Morita⁸, Kurisu Tada⁹, Naoho Takizawa¹⁰, Naoto Tamura⁹, Atsuo Taniguchi³, Yoshinori Taniguchi¹¹, Shigeyoshi Tsujii¹², Yoichiro Haji¹³, Masei Suda¹⁴, Haruyuki Yanaoka¹⁵, Ryo Rokutanda¹⁴, Masato Okada¹⁴, Clementina López Medina¹⁶, Anna Molto¹⁷, Maxime Dougados¹⁶, Désirée van der Heijde¹⁸, Shigeto Kobayashi¹⁹, Tetsuya Tomita²⁰ and Mitsumasa Kishimoto¹⁴, ¹Immuno-rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ²Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, ³Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁴Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan, ⁵Department of Internal Medicine, Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, ⁶Department of Orthopedic Surgery, Shiga University of Medical Science, Shiga, Japan, ⁷Department of Rheumatology, Tonan Hospital, Hokkaido, Japan, ⁸Department of Orthopedic Surgery, Fujita Health University, Aichi, Japan, ⁹Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ¹⁰Department of Rheumatology, Chubu Rosai Hospital, Aichi, Japan, ¹¹Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi, Japan, ¹²Department of Orthopedics, Osaka Minami Medical Center, Osaka, Japan, ¹³Department of Rheumatology, Daido Hospital, Aichi, Japan, ¹⁴Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ¹⁵St. Luke's International Hospital, Tokyo, Japan, ¹⁶Department of Rheumatology, Paris Descartes University, Cochin Hospital, Paris, France, ¹⁷Department of Rheumatology, Paris Descartes University, Cochin Hospital, Paris, Japan, ¹⁸Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ¹⁹Department of Internal Medicine, Juntendo University Koshigaya Hospital, Saitama, Japan, ²⁰Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine, Osala, Japan

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Spondylarthritis

Session Information

Date: Sunday, October 21, 2018

Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster I: Imaging, Clinical Studies, and Treatment

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: To delineateclinical characteristicsof patients with spondyloarthritis (SpA) in Japan in comparison to other areas of the world.

Methods: Utilizingthe COMOSPA data, an international cross-sectional observational study of SpA patients we analyzed information on demographics, disease characteristics, comorbidities,and risk factors. Patients were classified by region:Japan, other Asia (China, Singapore, South Korea, and Taiwan), and non-Asian countries (Europe, Americas, and Africa);patient characteristics, including diagnosis and treatment, were compared.

Results: Among 3984 patients included in the study, 161 were from centers in Japan, 933 from other Asian countries, and 2890 from other regions. Of SpA patients in Japan, 28.6%had peripheral SpA, whereas presenting symptoms were more predominantly axial in other Asian countries. Thistrendwas explained by the predominance of PsA patients among Japanese SpA patients. In contrast to the relatively low number in Japan, 54% of patients from other Asiancountries had pure axial SpAwithout peripheral features. HLA B27 testing, which is considered an integral part of the classificationof axial SpA, was only performed in 62%ofJapanese axial SpA patients. More than half of Japanese axial SpA patients were classified usingimaging criteria.

Conclusion: There is substantially more peripheral SpA in Japan compared to other parts of Asia, and other regions of the world. Aside from ethnicdifferences, increasing recognition of PsA,as well as a potential under-diagnosis of axial SpA due to the insufficient use of HLA B27 testingin Japan,may partly explain regionaldiscrepancies.

Disclosure: H. Sawada, None; K. Yoshida, None; N. Ichikawa, None; H. Inoue, None; Y. Kaneko, None; T. Kawasaki, None; K. Matsui, None; M. Morita, None; K. Tada, None; N. Takizawa, None; N. Tamura, None; A. Taniguchi, None; Y. Taniguchi, None; S. Tsujii, None; Y. Haji, None; M. Suda, None; H. Yanaoka, None; R. Rokutanda, None; M. Okada, None; C. López Medina, None; A. Molto, None; M. Dougados, None; D. van der Heijde, None; S. Kobayashi, None; T. Tomita, None; M. Kishimoto, Novartis, 5.

To cite this abstract in AMA style:

Sawada H, Yoshida K, Ichikawa N, Inoue H, Kaneko Y, Kawasaki T, Matsui K, Morita M, Tada K, Takizawa N, Tamura N, Taniguchi A, Taniguchi Y, Tsujii S, Haji Y, Suda M, Yanaoka H, Rokutanda R, Okada M, López Medina C, Molto A, Dougados M, van der Heijde D, Kobayashi S, Tomita T, Kishimoto M. Clinical Characteristics of Spondyloarthritis Patients in Japan in Comparison to Other Regions of the World [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/clinical-characteristics-of-spondyloarthritis-patients-in-japan-in-comparison-to-other-regions-of-the-world/. Accessed .

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