ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 2303

Clinical Characteristics Of Rheumatoid Factor-Positive Or Negative Subsets Of Anti-Citrullinated Peptide/Protein Antibody-Negative Rheumatoid Arthritis

Ryosuke Hiwa1, Koichiro Ohmura1, Noriyuki Yamakawa1, Moritoshi Furu2, Chikashi Terao3, Ran Nakashima1, Yoshitaka Imura4, Naoichiro Yukawa5, Hajime Yoshifuji1, Motomu Hashimoto6, Hiromu Ito2, Takao Fujii2 and Tsuneyo Mimori1,2, 1Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 3Center for Genomic Medicine, Kyoto University, Kyoto, Japan, 4Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 5Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 6The Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: Anti-citrullinated protein/peptide antibodies (ACPA) and rheumatoid arthritis (RA), Rheumatoid Factor

  • Tweet
  • Email
  • Print
Session Information

Session Title: Rheumatoid Arthritis-Clinical Aspects III: Outcome Measures, Socioeconomy, Screening, Biomarkers in Rheumatoid Arthritis

Session Type: Abstract Submissions (ACR)

Background/Purpose: Although anti-citrullinated peptide/protein antibody (ACPA) is a specific autoantibody for rheumatoid arthritis (RA), ~20% of RA are ACPA negative. It has been reported that ACPA(-) RA is a distinct subset clinically and genetically; radiographic progression is more severe in ACPA(+) RA and HLA-DR shared epitope is not associated with ACPA(-) RA. Recently we further subdivided ACPA(-) RA into rheumatoid factor (RF) positive and negative subsets and showed that HLA usage is different between ACPA(-)RF(+) RA and ACPA(-)RF(-) RA. Here we investigated the clinical characteristics of each subset.

Methods: RA patients were registered in the KURAMA cohort from May 2011 through May 2013 at Kyoto University Hospital and all the patients were Japanese. Titer of ACPA in sera or plasma was measured with the 2nd generation anti-CCP antibody ELISA kit. RF were measured with latex agglutination turbidimetric immunoassay. A patient was considered to be RF-negative when all the available tests were negative for RF. Age, sex, distribution of affected joints, positivity of anti-nuclear antibody (ANA), disease activity and treatment were assessed. Van der Heijde modified Sharp score (mTSS) of hands & feet X-ray films were scored by two evaluators.

Results: 84 out of 451 RA patients were negative for ACPA. In the ACPA negative group, 43 were positive for RF and 41 were RF-negative. There were significantly more women in RF-positive subset compared to RF-negative (88.4% and 70.7%, respectively). Distribution of affected joints and positivity of ANA, disease activity (DAS28-ESR, SDAI) were similar among the two subsets. Administration of methotrexate, oral glucocorticoid and biologic DMARDs were also similar. The mean of mTSS divided by the disease duration (mTSS/Y) of RF-positive subset were greater than RF-negative subset although there was no statistically significant difference (9.81±1.00 and 8.88±9.62, respectively). The other results were shown in table 1.

Table 1. Clinical characteristics of ACPA(-)RF(+) RA and ACPA(-)RF(-) RA

*mTSS were evaluated for 35 ACPA(-)RF(+) and 28 ACPA(-)RF(-) RA patients.

Conclusion:

Although ACPA(-)RF(+) RA and ACPA(-)RF(-) RA are genetically distinct, there seems to be no substantial clinical differences between those two subsets.


Disclosure:

R. Hiwa,
None;

K. Ohmura,
None;

N. Yamakawa,
None;

M. Furu,
None;

C. Terao,
None;

R. Nakashima,
None;

Y. Imura,
None;

N. Yukawa,
None;

H. Yoshifuji,
None;

M. Hashimoto,
None;

H. Ito,
None;

T. Fujii,
None;

T. Mimori,
None.

  • Tweet
  • Email
  • Print

« Back to 2013 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/clinical-characteristics-of-rheumatoid-factor-positive-or-negative-subsets-of-anti-citrullinated-peptideprotein-antibody-negative-rheumatoid-arthritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2022 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.