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Abstracts tagged "Rheumatoid Factor"

  • Abstract Number: 1698 • ACR Convergence 2020

    Polyarthritis Workup in Primary Care Setting : How Are We Doing?

    Ruhani Desai1, Cassandra Calabrese2, Neel Patel3 and Jessica Donato4, 1Cleveland Clinic Foundation, DeLand, FL, 2Cleveland Clinic, Cleveland, OH, 3Case Western Reserve University, Cleveland, OH, 4Cleveland Clinic Foundation, Cleveland

    Background/Purpose: Joint pain is a common presenting complaint in Primary Care with around 54.4 million adults diagnosed with some form of arthritis per 2013 CDC survey. Polyarthritis…
  • Abstract Number: 1720 • ACR Convergence 2020

    Factors Associated with an Increased Risk of Imminent Rheumatoid Arthritis in ACPA+ Individuals

    Hyoun-Ah Kim1, Ryan Peterson2, Gary Firestein3, David Boyle4, Jane Buckner5, Sylvia Posso6, Eddie James5, William Robinson7, Jaron Arbet2, LauraKay Moss8, Roger Gilmore8, Lindsay Hartje8, Saman Barzideh8, Jennifer Seifert9, Navin Rao10, Frédéric Baribaud11, Sunil Nagpal12, Alyssa Johnson13, V Michael Holers14 and Kevin D. Deane15, 1University of Colorado Anschutz Medical Campus and Ajou University School of Medicine, Aurora, CO, 2Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, 3University of California, San Diego, La Jolla, CA, 4UC San Diego, San Diego, CA, 5Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, 6Benaroya Research Institute at Virginia Mason, Seattle, WA, 7Stanford University, Palo Alto, CA, 8University of Colorado Anschutz Medical Campus, Aurora, CO, 9Division of Rheumatology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA, Littleton, CO, 10Janssen R&D, Spring House, PA, 11Janssen Research & Development, LLC, Spring House, PA, 12Janssen Reserach and Development, Spring House, PA, 13Janssen Research and Development, Spring House, PA, 14Division of Rheumatology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA, Colorado, 152 Division of Rheumatology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA, Colorado

    Background/Purpose: Individuals at high-risk for future rheumatoid arthritis (RA) may be identified by screening for circulating RA-related autoantibodies including antibodies to citrullinated protein antigens (ACPA).…
  • Abstract Number: 1721 • ACR Convergence 2020

    Increasing Autoantibody Positivity During Pre-RA Is Associated with the Imminent Development of Classifiable RA

    Heinrich-Karl Greenblatt1, Ted Mikuls2, Jess Edison3, Marie Feser4, Mark Parish5, LauraKay Moss5, Elizabeth Mewshaw6 and Kevin D. Deane7, 1University of Colorado School of Medicine, Aurora, CO, 2University of Nebraska Medical Center, Omaha, NE, 3Walter Reed National Military Medical Center, Bethesda, 4Division of Rheumatology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA, Colorado, 5University of Colorado Anschutz Medical Campus, Aurora, CO, 6Walter Reed National Military Medical Center, Bethesda, MD, 72 Division of Rheumatology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA, Colorado

    Background/Purpose: Autoantibodies including rheumatoid factor (RF) and antibodies to citrullinated protein antigens (ACPA) may be elevated during a period that can be termed ‘Pre-RA’. In…
  • Abstract Number: 1753 • ACR Convergence 2020

    Substantial Work Limitations in Patients with Rheumatoid Arthritis Despite Optimal Treat-to-Target (T2T) Drug Therapy Intervention

    Sara Eileen Meyer1, Julianna Rachel Hoeper2, Kirsten Hoeper1, Torsten Witte3 and Dirk Meyer-Olson4, 1Medizinische Hochschule Hannover, Klinik für Rheumatologie und Immunologie und Regionales Kooperatives Rheumazentrum Niedersachsen e.V., Hanover, Germany, 2Center for Health Economics Research Hannover, Leibniz Universität Hannover, Hannover, Hanover, Germany, 3Medizinische Hochschule Hannover, Klinik für Rheumatologie und Immunologie und Regionales Kooperatives Rheumazentrum Niedersachsen e.V., Hannover, Germany, 4Medizinische Hochschule Hannover, Klinik für Rheumatologie und Immunologie und Regionales Kooperatives Rheumazentrum Niedersachsen e.V., m&i Fachklinik Bad Pyrmont und Medizinisches Forschungszentrum Weserbergland, Hanover, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is associated with restrictions on occupational participation caused by periods of sick leave (absenteeism), reduced productivity at work due to disease…
  • Abstract Number: 0157 • ACR Convergence 2020

    Early Arthritis Global Assesment: What Differences Exist Between Patients and Physicians?

    Cristina Valero1, Noelia Garcia1, Juan Pablo Baldivieso2, Ana Ortiz3, Sebastian Rodriguez2 and Isidoro González-Álvaro3, 1Hospital Universitario de la Princesa, IIS-Princesa, UAM, Madrid, Madrid, Spain, 2Hospital de La Princesa, Madrid, Madrid, Spain, 3Hospital Universitario de la Princesa, IIS-Princesa, Madrid, Madrid, Spain

    Background/Purpose: In recent years there is increasing evidence of the relevance of including the assessment of the different aspects of rheumatoid arthritis (RA) from the…
  • Abstract Number: 0182 • ACR Convergence 2020

    Chronic Kidney Disease Is Underestimated in Patients with Rheumatoid Arthritis – Real World Data Gathered from a Network of Rheumatologists

    Stefan Kleinert1, Peter Bartz-Bazzanella2, Cay von der Decken3, Kirsten Karberg4, Florian Schuch5, Georg Gauler6, Patrick Wurth7, Susanna Spaethling-Mestekemper8, Christoph Kuhn9, Matthias Englbrecht10, Wolfgang Vorbrueggen11 and Martin Welcker12, 1Rheumatology-Nephrology Practice, Erlangen, Germany, 2Department of Rheumatology, Internal Medicine, Rhein-Maas-Hospital, Wuerselen, Germany, 3Medical Centre Stolberg, Stolberg, Germany, 4Practice for Rheumatology and Internal Medicine, Berlin, Germany, 5Rheumatology-Nephrology Practice, Erlangen, 6Rheumatology Practice, Osnabrueck, 7Rheumatology Practice, Osnabrueck, Germany, 8Rheumatology Group Practice, Muenchen, Germany, 9Rheumatology Practice, Karlsruhe, 10Freelance Healthcare Data Scientist, Eckental, Germany, 11Foundation for fostering rheumatology, Wuerselen, Germany, 12MVZ für Rheumatologie Dr. M. Welcker, Planegg, Germany

    Background/Purpose: Patient registries have become a common approach to learn from patient-related data by prospectively including large numbers of individuals into a sample followed over…
  • Abstract Number: 0754 • ACR Convergence 2020

    The Association Between Continuous Decreases in Serum RF Titers and Radiographic Remission of Joint Damage in RA Patients Treated with Biological or Targeted Synthetic DMARDs

    Takayoshi Owada1, Ayae Tanaka2, Hirokuni Hirata1, Masafumi Arima3, Yasutsugu Fukushima1 and Kazuhiro Kurasawa3, 1Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama, Japan, 2Dokkyo Medical University, Shimotsuga-Gun, Japan, 3Dokkyo Medical University, Mibu, Shimotsugagun, Tochigi, Japan

    Background/Purpose: Rheumatoid factors (RFs) are RA-related autoantibodies like anti-cyclic citrullinated peptide antibodies, and are used for classifying and diagnosing RA. In addition, positivity and high…
  • Abstract Number: 0758 • ACR Convergence 2020

    Anti-citrullinated Protein Antibodies Are Associated with Functional Disability in Unaffected First-degree Relatives of Rheumatoid Arthritis Patients

    Dana Wiens1, Irene Smolik1, Xiaobo Meng1, Vidyanand Anaparti1, Hani El-Gabalawy1 and Liam O'Neil1, 1University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: The preclinical stage of Rheumatoid Arthritis (RA) is characterized by seropositivity for anti-citrullinated protein antibodies (ACPA). We (PubMed ID 30861615), and others, have shown that ACPA seropositivity…
  • Abstract Number: 0768 • ACR Convergence 2020

    Dynamics of Follicular Helper T Cells Subsets in Rheumatoid Arthritis Patients Before and After Treatment

    Paola Virginia Ferrero1, Luisina Onofrio1, Cristina del Valle Acosta1, Estefania Raquel Zacca1, Nicolas Eric Ponce2, Eduardo Mussano1, Ignacio Isaac Cadile1, Laura Onetti1, Marina Werner1, Alicia Beatriz Costantino1, Eva Virginia Acosta Rodriguez3 and Adriana Gruppi2, 1HOSPITAL NACIONAL DE CLINICAS, FACULTAD DE MEDICINA, UNIVERSIDAD NACIONAL DE CORDOBA, CORDOBA, Cordoba, Argentina, 2FACULTAD DE CIENCIAS QUIMICAS, UNIVERSIDAD NACIONAL DE CORDOBA. CENTRO DE INVESTIGACIONES EN BIOQUIMICA CLINICA E INMUNOLOGIA, CORDOBA, Cordoba, Argentina, 3FACULTAD DE CIENCIAS QUIMICAS, UNIVERSIDAD NACIONAL DE CORDOBA. CENTRO DE INVESTIGACIONES EN BIOQUIMICA CLINICA E INMUNOLOGIA, CORDOBA, Argentina

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by the production of autoantibodies like rheumatoid factor and anti- citrullinated protein. CD4+ follicular helper T…
  • Abstract Number: 0813 • ACR Convergence 2020

    Treatment Outcomes in Patients with Seropositive versus Seronegative Rheumatoid Arthritis in Czech Registry ATTRA Treated with JAK Inhibitors

    Karel Pavelka1 and Zlatuše Křístková2, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Biostatistics and Analyses, Ltd., Brno, Czech Republic

    Background/Purpose: Seropositivity / seronegativity in RA may have influence on response to bDMARDs or tsDMARDs. There is incomplete knowledge of differences in efficacy of JAK…
  • Abstract Number: 145 • 2020 Pediatric Rheumatology Symposium

    Anti-Citrullinated Protein Antibodies (ACPA) and Bony Erosions in Polyarticular JIA

    Saumya Joshi1, Yujuan Zhang 1 and Trevor Davis 2, 1Tufts Medical Center, Boston, Massachusetts, 2Norwell, Massachusetts

    Background/Purpose: Despite being a well-established biomarker for classification of aggressive bony disease in adults with RA, ACPA have not yet been described in the ILAR…
  • Abstract Number: 51 • 2019 ACR/ARP Annual Meeting

    Cigarette Smoking Has Different Impacts on ACPA and RF Production Depending on Shared Epitope Allele Status in Japanese RA Patients; A Study with the Two Independent Japanese Cohorts (IORRA and KURAMA)

    Yuki Ishikawa1, Motomu Hashimoto 2, Katsunori Ikari 3, Koichiro Ohmura 4, Masao Tanaka 4, Hiromu Ito 4, Atsuo Taniguchi 3, Hisashi Yamanaka 3, Tsuneyo Mimori 4 and Chikashi Terao 5, 1Joslin Diabes Center, Boston, MA, 2Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3Tokyo Women’s Medical University, Tokyo, Japan, 4Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5RIKEN, Tokyo, Japan

    Background/Purpose: In rheumatoid arthritis (RA), cigarette smoking affects both rheumatoid factor (RF) and anti-citrullinated cyclic peptide/protein antibody (ACPA) production, but its association in relation to…
  • Abstract Number: 464 • 2019 ACR/ARP Annual Meeting

    Continuous Decrease in Serum RF Titer During Anti-TNF Therapy Was Associated with Suppression in Progression of RA Joint Damage

    Takayoshi Owada1, Kazuhiro Kurasawa 1, Yuta Takamura 1, Toshiyuki Miyao 1, Ayae Tanaka 1, Ryutaro Yamazaki 1, Satoko Arai 1, Reika Maezawa 1 and Masafumi Arima 1, 1Dokkyo Medical University, Mibu-machi, Shimotsuga-gun, Tochigi, Japan

    Background/Purpose: A number of studies have investigated the association between serum RF and joint damage in early and established RA patients, and positive and high-titer…
  • Abstract Number: 1504 • 2018 ACR/ARHP Annual Meeting

    Utility of Serial ACPA Measurements in Rheumatoid Arthritis: Results of a Prospective Cohort Study

    Alistair Reid1,2,3, Michael D Wiese4, Robert Metcalf5, Mihir D Wechalekar6,7, Anita Lee8,9, Catherine Hill2,10,11, Cindy Hall8, Leah McWilliams5, Les Cleland8 and Susanna Proudman12, 1Rheumatology, Royal Adelaide Hospital, NORTH ADELAIDE, Australia, 2Medicine, The University of Adelaide, Adelaide, Australia, 3Medicine, University of Wollongong, Wollongong, Australia, 4School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia, 5Rheumatology Unit, Royal Adelaide Hospital, South Australia, Adelaide, Australia, 6Royal Adelaide Hospital, Adelaide, Australia, 7Rheumatology, Flinders University, Adelaide, Australia, 8Rheumatology, Royal Adelaide Hospital, Adelaide, Australia, 9Rheumatology, University of Adelaide, Adelaide, Australia, 10The Queen Elizabeth Hospital, Adelaide, Australia, 11Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, 12Royal Adelaide Hospital, Rheumatology Unit and University of Adelaide, Discipline of Medicine, Adelaide, Australia

    Background/Purpose: Anti-citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) define “seropositive” rheumatoid arthritis (RA). Both predict disease course, development of extra-articular features and treatment outcomes.…
  • Abstract Number: 1858 • 2018 ACR/ARHP Annual Meeting

    An Assay Panel Combining Anti-Protein Arginine Deiminase 4 with Rheumatoid Factor Isotypes Distinguishes Anti-Citrullinated Peptide Antibody Negative Rheumatoid Arthritis

    Thierry Dervieux1, Laura Martinez Prat2, John Conklin1, Claudia Ibarra1, Michael Mahler2, Michael E Weinblatt3 and Joel Kremer4, 1Exagen Diagnostics, Inc., Vista, CA, 2Research and Development, Inova Diagnostics, San Diego, CA, 3Brigham and Women's Hospital, Boston, MA, 4Albany Medical College and The Center for Rheumatology, Albany, NY

    Background/Purpose: Anti-citrullinated peptide antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA) but lack sensitivity. We evaluated autoantibodies to protein-arginine deiminase 4 (anti-PAD4) in distinguishing…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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