Date: Sunday, November 8, 2020
Session Title: Systemic Sclerosis & Related Disorders – Clinical Poster III
Session Type: Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Chronic graft-vs-host disease (cGVHD) is a major late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT), typically occurring within three years post-transplant and affecting approximately 30%-50% of allogeneic transplant survivors. Although cGVHD can involve many organ systems, joint and fascial involvement is relatively common, little known and can cause significant functional impairment.
Describe the clinical/transplant related characteristics, the therapeutic management and the clinical outcome of a cohort of patients with joint and fascial involvement in the context of cGVHD.
Methods: Observational and retrospective study to describe the clinical characteristics of 28 patients affected by joint and fascial cGVHD. The usual demographic variables, the transplant reason disease, the type of transplant,laboratory parameters, rescue therapies and their response were collected. The statistical analysis was done with Microsoft Excel 2007.
Results: Seventeen (60.7%) patients were male and 11 (39.35%) were women with a mean age of 48.75 years (range from 10 to 74). Acute myeloid leukemia was the most frequent cause of the transplant in 11 patients (39.3%)
Transplant related characteristics are reflected in Table 1 and the clinical manifestations, therapies received and their response in Table 2.. Eighteen (64,3%) presented irreversible contracture due to sclerosis that negatively impacts their quality of life and physical function (11/39%).
Four (14.2%) patients died during their follow-up, being the cause of death in 2 cases due to sepsis, in 1 case due to leukemia relapse and in 1 case attributable to cGVHD.
Conclusion: Nonspecific joint symptoms such as stiffness, edema or arthromyalgia may be factors that predict the development of joint/fascial involvement in cGVHD.
They should be closely monitored in order to be able to perform early stage diagnoses and implementation of proper treatment, including rehabilitation, in order to restore function and improve the quality of life of these patients.
To cite this abstract in AMA style:Hidalgo Calleja C, Román Curto C, Gómez-Lechón L, Acosta M, Compán O, Pastor S, Montilla Morales C, Pantoja Zarza L, Sánchez González M, López Corral L. Clinical Characteristics and Treatment Outcome of a Cohort of Patients with Joint and Fascial Involvement in the Context of Chronic Graft versus Host Disease [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/clinical-characteristics-and-treatment-outcome-of-a-cohort-of-patients-with-joint-and-fascial-involvement-in-the-context-of-chronic-graft-versus-host-disease/. Accessed October 15, 2021.
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