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Abstract Number: 2295

Burden of Systemic Lupus Erythematosus Among Korean Women in Childbearing Years Based on the National Health Insurance Service Data

Min Kyung Chung 1, Jin Su Park 2, Hyun Sun Lim 2, Chan Hee Lee 2 and Jisoo Lee1, 1Division of Rheumatology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea, 2Division of Rheumatology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: Comorbidity, medication and pregnancy, Reproductive Health, Systemic lupus erythematosus (SLE)

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Session Information

Date: Tuesday, November 12, 2019

Session Title: Reproductive Issues In Rheumatic Disorders Poster

Session Type: Poster Session (Tuesday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Most women with systemic lupus erythematosus (SLE) are diagnosed with the disease in their reproductive ages, but the burden of SLE among women in childbearing years remains incompletely understood. We aimed to investigate the burden of SLE among Korean women in childbearing years in terms of prevalence and incidence of disease, prevalence of comorbidity, medication dispensing, and pregnancy and delivery rate.

Methods: From National Health Insurance Service data during 2009-2016, women between 20-44 years of childbearing years were identified. Among these women, the prevalence and incidence of SLE were estimated. Women without chronic diseases (CD) or rheumatic diseases including SLE, rheumatoid arthritis, and ankylosing spondylitis were defined as controls. Prevalence of CD including cancer (Ca), diabetes mellitus (DM), hypertension (HTN), and hyperlipidemia (HLD) was compared in SLE women and controls. Medication uses including NSAIDs, corticosteroids (CSs), and conventional (c) disease-modifying anti-rheumatic drugs (DMARDs), pregnancy and delivery rates in women with SLE were compared with controls.

Results: Total 12,756 women with SLE and 208,941 controls were identified. The overall prevalence of SLE during 2009-2016 was 138.5 (95% CI 136.1-140.9) per 100,000 and overall incidence of SLE was 49.1 (95% CI 47.7-50.5) per 100,000 females in childbearing years during 2011-2016. SLE women had significantly increased prevalence of CD compared with the controls in the same age group (60.4% vs 25.6%, odds ratio (OR) 5.4, p< 0.0001). Each chronic disease including Ca (6.3% vs 4.2%, OR 4.2), DM (9.7% vs 6.0%, OR 1.9), HTN (35.2% vs 8.2%, OR 8.0), and HLD (38.3% vs 16.6%, OR 3.6) were all more prevalent in SLE women compared with the controls (p< 0.001). The use of any rheumatic diseases related medications including NSAIDs, CSs, cDMARDs were more frequent in women with SLE than controls (NSAIDs; 53.6% vs 21.8%, CSs; 81.0% vs 4.3%, cDMARDs; 89.0% vs 0.4%, all p< 0.001). Although pregnancy rate showed no difference between SLE women and controls (22.1% vs 19.3%, OR=0.97, p=0.38), delivery rate was significantly lower in SLE women compared with controls (18.7% vs 20.3%, OR 0.8, p< 0.001).

Conclusion: High prevalence and incidence, increased rates of comorbidities and medication use, and decreased odds to have successful delivery are causes of a significant burden in Korean women with SLE during their childbearing years.


ACR2019_Table1

Prevalence of chronic diseases among women with SLE in childbearing age between 20-44 years during 2009-2016


Disclosure: M. Chung, None; J. Park, None; H. Lim, None; C. Lee, None; J. Lee, None.

To cite this abstract in AMA style:

Chung M, Park J, Lim H, Lee C, Lee J. Burden of Systemic Lupus Erythematosus Among Korean Women in Childbearing Years Based on the National Health Insurance Service Data [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/burden-of-systemic-lupus-erythematosus-among-korean-women-in-childbearing-years-based-on-the-national-health-insurance-service-data/. Accessed April 13, 2021.
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