Autoimmune Uveitis : Potential Role of Interleukin-22 (IL-22) in Pathogenesis

El-Desouki Fouda¹, El-Sayed Mostafa Elewah², Mona Elrayes³, Ghada Fouda⁴ and Mohamed Ahmed Bakry⁵, ¹Al-Azhar University, Dokki Cairo, Egypt, ²Opthalmology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt, ³Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt, ⁴Faculty of Medicine, Al-Azhar University, Cairo, Egypt, ⁵Al-Azhar University, Allergy & Immunology Center, Cairo, Egypt

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: autoimmune diseases, Behcet's syndrome, uveitis and vasculitis

Session Information

Date: Tuesday, November 15, 2016

Title: Cytokines, Mediators, Cell-Cell Adhesion, Cell Trafficking and Angiogenesis - Poster II

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: : IL-22 is a member of IL-10 family, with both anti- inflammatory and pro- inflammatory functions, orchestrating the immune and inflammatory response.IL-22 is secreted by dendritic cells and T lymphocytes and act on non hematopoietic cells. Co-expressed IL-17A regulates the pro-inflammatory versus tissue-protective functions of IL-22. Behçet’s disease (BD) is a chronic systemic inflammatory disorder at the crossroad between autoimmune and auto inflammatory syndromes. Uveitis is a sight threatening condition affects 60-80 % of the BD patients (pts).We aimed at this study to investigate the potential role of IL – 22 in uveitis associated with BD.

Methods: Serum IL-22 was detected by ELISA in 35 uveitis pts and 10 healthy controls enrolled in 4 groups ; Group 1: pts with active uveitis associated with BD(n=11),Group 2: pts with inactive uveitis associated with BD (n=12), Group 3 : pts with uveitis without apparent auto immune and /or rheumatic manifestations (n=12) and Group 4 :healthy controls (n=10).

Results: The mean serum level of IL- 22 of BD pts with active uveitis was significantly very high compared to the control (p=0.001),the mean serum level of IL – 22 of BD pts with inactive uveitis was significantly high compared to those of healthy controls (p=0.001), the mean serum levels of IL-22of BD pts with active uveits was significantly higer than those of BD pts with inactive uveitis (p=0.01), the mean serum levels of IL-22 of non Behçet’s uveitis was not significantly different compared to healthy controls .Although comparing the mean serum levels of IL-22 based on site of ocular inflammation there was no statistical significance, it seems that pts of non Behçet’s with posterior uveitis had higher levels of IL-22 compared to those with anterior uveitis in the same group denoting the potential role of IL 22 in vasculopathy involving the choroid plexus.

Conclusion: We could suggest that IL – 22 play an important potential role in the pathogenesis of uveitis associated with BD vasculopathy and may serve as a biomarker of disease activity.

Disclosure: E. D. Fouda, None; E. S. Mostafa Elewah, None; M. Elrayes, None; G. Fouda, None; M. Ahmed Bakry, None.

To cite this abstract in AMA style:

Fouda ED, Mostafa Elewah ES, Elrayes M, Fouda G, Ahmed Bakry M. Autoimmune Uveitis : Potential Role of Interleukin-22 (IL-22) in Pathogenesis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/autoimmune-uveitis-potential-role-of-interleukin-22-il-22-in-pathogenesis/. Accessed .

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