Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: ETS Proto-oncogene 1, transcription factor (ETS1) is a transcription factor involved in immune responses. Genome-wide association studies on systemic lupus erythematosus (SLE) in Chinese populations identified the association of ETS1 polymorphism in 3’ untranslated region, rs1128334 A allele, which was associated with lower ETS1 expression. Recent studies indicated that many susceptibility genes are shared by multiple autoimmune diseases. In this study, we examined whether ETS1is associated with ANCA-associated vasculitis (AAV) in a Japanese population.
Methods: Association of rs1128334 was tested in 466 Japanese patients with AAV and 1099 healthy controls by logistic regression analysis under the additive model. AAV patients were classified into 285 microscopic polyangiitis (MPA), 92 granulomatosis with polyangiitis (GPA), 56 eosinophilic GPA, and 33 unclassifiable AAV, according to the European Medicines Agency (EMEA) algorithm. Among the patients, 376 were positive for MPO-ANCA and 62 for PR3-ANCA. Expression levels in ETS1 mRNA in the whole peripheral blood were compared between 8 AAV patients and 14 healthy controls.
Results: When the patients were classified according to the EMEA classification, rs1128334 A was significantly increased in GPA (P=0.0060, Pc=0.030, odds ratio [OR] 1.54, 95% confidence interval [CI] 1.13-2.10) when compared with healthy controls. With respect to the ANCA specificity, significant association was observed in PR3-ANCA positive AAV (P=0.0042, Pc=0.021, OR 1.72, 95% CI 1.19-2.49). Expression analysis indicated that ETS1 mRNA levels were decreased in AAV (P=0.0024).
Conclusion: ETS1 polymorphism was suggested to be associated with susceptibility to GPA and PR3-ANCA positive AAV in a Japanese population.
To cite this abstract in AMA style:Kawasaki A, Yamashita K, Hirano F, Sada KE, Tsukui D, Kondo Y, Kimura Y, Asako K, Kobayashi S, Yamada H, Furukawa H, Nagasaka K, Sugihara T, Yamagata K, Sumida T, Tohma S, Kono H, Ozaki S, Matsuo S, Hashimoto H, Makino H, Arimura Y, Harigai M, Tsuchiya N. Association of ETS1 Polymorphism in 3’ Untranslated Region with Susceptibility to Granulomatosis with Polyangiitis and Proteinase 3-ANCA Positive Vasculitis in a Japanese Population [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/association-of-ets1-polymorphism-in-3-untranslated-region-with-susceptibility-to-granulomatosis-with-polyangiitis-and-proteinase-3-anca-positive-vasculitis-in-a-japanese-population/. Accessed September 20, 2021.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/association-of-ets1-polymorphism-in-3-untranslated-region-with-susceptibility-to-granulomatosis-with-polyangiitis-and-proteinase-3-anca-positive-vasculitis-in-a-japanese-population/