Abstracts tagged "genetics and polymorphism"

Abstract Number: 1967 • 2018 ACR/ARHP Annual Meeting
Detection of Association of Long Noncoding RNA ATP6V0E2-AS1 Single Nucleotide Polymorphism with Susceptibility to Myeloperoxidase-ANCA Associated Vasculitis Based on Transcriptome Analysis
Yuka Iwahashi^1,2, Aya Kawasaki^1,2, Takayo Tsuchiura³, Ken-ei Sada⁴, Fumio Hirano^5,6, Daisuke Tsukui⁷, Shigeto Kobayashi⁸, Hidehiro Yamada⁹, Hiroshi Furukawa^1,2,10, Kenji Nagasaka¹¹, Takahiko Sugihara¹², Nao Nishida³, Kunihiro Yamagata¹³, Takayuki Sumida¹⁴, Shigeto Tohma^10,15, Shoichi Ozaki⁹, Hiroshi Hashimoto¹⁶, Hirofumi Makino¹⁷, Yoshihiro Arimura¹⁸, Hajime Kono¹⁹, Masayoshi Harigai²⁰ and Naoyuki Tsuchiya^1,2, ¹University of Tsukuba, Graduate School of Comprehensive Human Sciences, Masters' Program in Medical Sciences, Tsukuba, Japan, ²University of Tsukuba, Faculty of Medicine, Molecular and Genetic Epidemiology Laboratory, Tsukuba, Japan, ³Genome Medical Science Project, National Center for Global Health and Medicine, Research Center for Hepatitis and Immunology, Ichikawa, Japan, ⁴Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ⁵Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Department of Rheumatology, Tokyo, Japan, ⁶Tokyo Medical and Dental UniversityGraduate School of Medical and Dental Sciences, Department of Lifetime Clinical Immunology, Tokyo, Japan, ⁷Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁸Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, ⁹St. Marianna University, School of Medicine, Department of Internal Medicine, Kawasaki, Japan, ¹⁰National Hospital Organization Sagamihara l Hospital, Clinical Research Center for Allergy and Rheumatology, Sagamihara, Japan, ¹¹Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, ¹²Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, ¹³University of Tsukuba, Faculty of Medicine, Department of Nephrology, Tsukuba, Japan, ¹⁴Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ¹⁵National Hospital Organization Tokyo National Hospital, Kiyose, Japan, ¹⁶Juntendo University School of Medicine, Tokyo, Japan, ¹⁷Okayama University Hospital, Okayama, Japan, ¹⁸Kyorin University School of Medicine, First Department of Internal Medicine, Tokyo, Japan, ¹⁹Teikyo University School of Medicine, Department of Internal Medicine, Tokyo, Japan, ²⁰Tokyo Women's Medical University, Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo, Japan
Background/Purpose: Because of the low prevalence, only three genome-wide association studies, all from the Caucasian populations, have been reported on ANCA-associated vasculitis (AAV) thus far;…
Abstract Number: 1762 • 2017 ACR/ARHP Annual Meeting
Association of ETS1 Polymorphism in 3’ Untranslated Region with Susceptibility to Granulomatosis with Polyangiitis and Proteinase 3-ANCA Positive Vasculitis in a Japanese Population
Aya Kawasaki¹, Keita Yamashita², Fumio Hirano³, Ken-ei Sada⁴, Daisuke Tsukui⁵, Yuya Kondo⁶, Yoshitaka Kimura⁵, Kurumi Asako⁵, Shigeto Kobayashi⁷, Hidehiro Yamada⁸, Hiroshi Furukawa¹, Kenji Nagasaka⁹, Takahiko Sugihara¹⁰, Kunihiro Yamagata¹¹, Takayuki Sumida⁶, Shigeto Tohma¹², Hajime Kono⁵, Shoichi Ozaki⁸, Seiichi Matsuo¹³, Hiroshi Hashimoto¹⁴, Hirofumi Makino¹⁵, Yoshihiro Arimura¹⁶, Masayoshi Harigai¹⁷ and Naoyuki Tsuchiya¹, ¹Molecular and Genetic Epidemiology Laboratory, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ²Molecular and Genetic Epidemiology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ³Departments of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ⁵Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁶Department of Internal Medicine, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ⁷Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, ⁸Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁹Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, ¹⁰Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, ¹¹Department of Nephrology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ¹²Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ¹³Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ¹⁴Juntendo University School of Medicine, Tokyo, Japan, ¹⁵Okayama University Hospital, Okayama, Japan, ¹⁶First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan, ¹⁷Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: ETS Proto-oncogene 1, transcription factor (ETS1) is a transcription factor involved in immune responses. Genome-wide association studies on systemic lupus erythematosus (SLE) in Chinese…
Abstract Number: 1896 • 2013 ACR/ARHP Annual Meeting
Arthritis Associated Sequence Alterations Within a Genetic Susceptibility Region Of Mouse Chromosome 3; A Genomic Region Which Is Syntenic With a Prominent Non-MHC Locus In Rheumatoid Arthritis
Andras Vida¹, Timea Besenyei², Beata Tryniszewska¹, Timea Ocsko¹, Zoltan Szekanecz³, Tibor A. Rauch¹, Katalin Mikecz¹ and Tibor T. Glant¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Department of Rheumatology, University of Debrecen, Debrecen, Hungary, ³Rheumatology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that results in inflammatory destruction of synovial joints in affected patients. The involvement of genetic and epigenetic…
Abstract Number: 1639 • 2013 ACR/ARHP Annual Meeting
GWAS In Hispanic and Latin American Individuals Enriched For Amerindian Ancestry Identifies a New Locus Associated With Systemic Lupus Erythematosus
Marta Eugenia Alarcon Riquelme¹, Julie T. Ziegler², Mary E. Comeau³, Elena Sanchez⁴, Bernado Pons-Estel⁵, Eduardo Acevedo⁶, Jorge Mariano Cucho⁶, Ignacio Garcia de la Torre⁷, Mario H. Cardiel⁸, Pedro Miranda⁹, Luis Cattogio¹⁰, Marco Maradiaga¹¹, Jorge Esquivel-Valerio¹², Jose F Moctezuma¹³, Mercedes Garcia¹⁴, Guillermo Berbotto¹⁵, Alejandra Babini¹⁶, Hugo Scherbarth¹⁷, Sergio Toloza¹⁸, Judith A James¹⁹, Teresa Tusie-Luna²⁰, John B Harley²¹, Raphael Zidovetski²², Carl Langefeldt² and Chaim O. Jacob²³, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Wake Forest School of Medicine, Winston-Salem, NC, ³Wake Forest University Health Sciences, Winston-Salem, NC, ⁴King's College London, London, United Kingdom, ⁵Hospital Provincial de Rosario, Rosario, Argentina, ⁶Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru, ⁷Hospital General de Occidente, Zapopan, Mexico, ⁸Centro de Investigacion Clinica de Morelia, Morelia, Mexico, ⁹Universidad de Chile and Centro de Estudios Reumatologicos, Santiago de Chile, Chile, ¹⁰Hospital Italiano, Buenos Aires, Argentina, ¹¹Hospital General de Culiacán, Culiacan, Sinaloa, Mexico, ¹²Hospital Universitario Dr. José Eleuterio González, Universidad Autonoma de Nuevo León, Nuevo Leon, Mexico, ¹³Hospital General de Mexico, Mexico, Mexico, ¹⁴Hospital San Martin, La Plata, Argentina, ¹⁵Hospital Eva Peron, Granadero Baigorria, Argentina, ¹⁶Hospital Privado de Cordoba, Cordoba, Argentina, ¹⁷H.I.G.A. Oscar E. Alende, Mar del Plata, Argentina, ¹⁸Hospital San Juan Bautista, Catamarca, Argentina, ¹⁹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²⁰Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México, and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, ²¹Childrens Hospital, Cincinnati, OH, ²²University of Southern California, Los Angeles, CA, ²³Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA
Background/Purpose: Systemic lupus erythematosus (SLE), a chronic autoimmune disease with a strong genetic component, exhibits a 9:1 female to male ratio and disproportionate impact on…

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