Association of Anti-Glutamate Receptor Subunit NR2 Antibody and Psychiatric Disorder in Patients with Primary Sjögren Syndrome

Yoshiyuki Arinuma^1,2, Yuko Sakuma³, Eisuke Ogawa², Tatsuhiko Wada⁴, Tatsuo Nagai², Sumiaki Tanaka² and Shunsei Hirohata², ¹Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, ²Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ³Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ⁴Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: autoantibodies, central nervous system involvement and psychological status, Sjogren's syndrome, SLE

Session Information

Date: Tuesday, November 10, 2015

Title: Sjögren's Syndrome: Translational Insights into Sjögren's Syndrome

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:
Sjögren syndrome (SjS) is one of the autoimmune disease characterized by the
production of autoantibodies. Patients with SjS frequently observe psychiatric manifestation
such as depression, anxiety and cognitive dysfunction as is often seen in
patients with systemic lupus erythematosus (SLE). Anti-glutamate receptor
subunit NR2 antibodies (anti-NR2) is one of the pathogenic autoantibodies related
to psychiatric disorder (PD) in patients with SLE. However, anti-NR2 in patients
with SjS has not been clarified. The aim of this study is to investigate the
association of anti-NR2 and PD in patients with primary SjS (pSjS).

Methods:
We examined 35 patients with pSjS, 17 patients with rheumatic diseases other
than SLE or SjS as disease control (DC) and 36 healthy individuals (HC).
Anti-NR2 in serum were measured by ELISA.

Results:
The level of anti-NR2 in serum was significantly elevated in patients with
pSjS (47.3±69.4U/ml), compared to those with DC (14.0±16.6, p=0.0043) or HC
(16.8±9.6, p=0.0226). In pSjS patients with PD, the serum anti-NR2 level was
significantly higher than that in patients without PD (p=0.0003). Also, the
positivity of anti-NR2 in serum from patients with pSjS was found to be a significant risk factor for PD in pSjS patients
(OR 38.0, 95%CI 5.5-789.3, p=0.0018) by logistic regression analysis.

Conclusion:
Anti-NR2 are significantly associated
with PD in patients with pSjS.

Disclosure: Y. Arinuma, None; Y. Sakuma, None; E. Ogawa, None; T. Wada, None; T. Nagai, None; S. Tanaka, None; S. Hirohata, None.

To cite this abstract in AMA style:

Arinuma Y, Sakuma Y, Ogawa E, Wada T, Nagai T, Tanaka S, Hirohata S. Association of Anti-Glutamate Receptor Subunit NR2 Antibody and Psychiatric Disorder in Patients with Primary Sjögren Syndrome [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/association-of-anti-glutamate-receptor-subunit-nr2-antibody-and-psychiatric-disorder-in-patients-with-primary-sjogren-syndrome/. Accessed .

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