Abstracts tagged "hyperuricemia"

Abstract Number: 1221 • 2019 ACR/ARP Annual Meeting
Impact of Psoriasis Disease Activity and Other Risk Factors on Serum-urate Levels in Patients with Psoriasis and Psoriatic Arthritis – A Post-hoc Analysis of Pooled Data from Three Phase 3-trials with Secukinumab
Mats Dehlin¹, Andreas Fasth ², Maximilian Reinhardt ³ and Lennart Jacobsson ⁴, ¹Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden, Gothenburg, Sweden, ²Medical Affairs, Novartis Sverige AB, Kista, Sweden, Stockholm, Sweden, ³Medical Affairs, Novartis Pharma GmbH, Nürnberg, Germany, Nürnberg, Germany, ⁴Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden,, Gothenburg, Sweden
Background/Purpose: Increased serum uric acid (sUA), hyperuricemia, has been reported to be associated with psoriasis (1). Increased cell turnover in psoriatic skin lesions has been…
Abstract Number: 1223 • 2019 ACR/ARP Annual Meeting
Enteral Administration of ALLN-346, a Recombinant Urate-degrading Enzyme, Decreases Serum Urate in a Pig Model of Hyperuricemia
Danica Grujic¹, Kateryna Pirzynowska ², Paulina Szczurek ³, Stefan Pierzynowski ², Aditi Desphande ⁴, Olha Drahanchuck ⁵, Nadia Mosiichuk ⁶ and Jarek Wolinski ⁷, ¹Allena Pharmaceuticals, Boston, ²Lund University, Anara AB,/SGPlus, Lund, Sweden, ³National Research Institute of Animal Production, Vitanano Sp. z o.o./PROF,, Balice, Poland, ⁴Allena Pharmaceuticals, Newton, MA, ⁵Polish Academy of Sciences, Vitanano Sp. z o.o./PROF,, Jablonna, Poland, ⁶Lund University, Lund, Sweden, ⁷Polish Academy of Sciences, Vitanano Sp. z o.o./PROF, Jablonna, Poland
Background/Purpose: Uric acid homeostasis is determined as a balance between production, intestinal secretion and renal excretion. Around 2/3 of uric acid is excreted by the…
Abstract Number: 1229 • 2019 ACR/ARP Annual Meeting
AR882, a Potent and Selective Uric Acid Lowering Agent Acting Through Inhibition of Uric Acid Reuptake, Shows Excellent Pharmacokinetics and Pharmacodynamics in a Phase 1 Clinical Trial
zancong shen ¹, Elizabeth Polvent ², Vijay Hingorani ³, Shunqi Yan ⁴, Rongzi Yan ⁴ and Litain Yeh⁴, ¹Arthrosi Therapeutics, San Diego, CA, ²Arthrosi Therapeutics, Laguna Hills, CA, ³Arthrosi Therapeutics, San Diego, ⁴Arthrosi Therapeutics, Laguna Hills
Background/Purpose: AR882 is a potent and selective uric acid transporter 1 (URAT1) inhibitor under development for the treatment of hyperuricemia or gout. A Phase 1…
Abstract Number: 1233 • 2019 ACR/ARP Annual Meeting
Identification and Characterization of a Novel Dysfunction Variant p.I242T in ABCG2 Transporter in a Family with Early-onset Hyperuricamia and Gout
Blanka Stiburkova¹, Yu Toyoda ², Katerina Pavelcova ³, Martin Klein ⁴, Tappei Takada ² and Hiroshi Suzuki ², ¹Institute of Rheumatology; Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic, Prague, Czech Republic, ²Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan, Tokyo, Japan, ³Institute of Rheumatology; Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁴Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: ABCG2 is a high-capacity urate transporter gene. Common dysfunctional variants of ABCG2 that result in decreased urate excretion in humans are major causes of…
Abstract Number: 1234 • 2019 ACR/ARP Annual Meeting
Inconsistency in Uric Acid Reference Ranges Among 20 Top United States Hospitals: What Is “Normal”?
Brittany Frankel¹, Grant Hughes ¹ and Mark Wener ¹, ¹University of Washington, Seattle, WA
Background/Purpose: Elevated serum uric acid (UA) concentration is associated with the urate crystal deposition disorders gout and nephrolithiasis, as well as hypertension, the metabolic syndrome,…
Abstract Number: 2051 • 2019 ACR/ARP Annual Meeting
Factors in Achieving Serum Uric Acid Target and the Occurrence of Gouty Arthritis: A Cross-sectional Study Based on Japanese Health Insurance Claim Data
Ruriko Koto¹, Akihiro Nakajima ¹, Hideki Horiuchi ¹ and Hisashi Yamanaka ², ¹Teijin Pharma Limited, Chiyoda-ku, Tokyo, Japan, ²Sanno Medical Center, Minato-ku, Tokyo, Japan
Background/Purpose: The number of gout attacks can be reduced by achieving and maintaining serum uric acid (sUA) at or below 6.0 mg/dL, a level uniformly…
Abstract Number: 2065 • 2019 ACR/ARP Annual Meeting
Association Between Anemia and Hyperuricemia: Korean National Health and Nutrition Survey 2016-2017
Seulkee Lee¹, Yeonghee Eun ¹, Jiwon Hwang ², Hoon-Suk Cha ¹, Eun-Mi Koh ¹, Jaejoon Lee ¹ and Hyungjin Kim ¹, ¹Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, ²Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea
Background/Purpose: Hyperuricemia and anemia may be related in terms of sharing comorbidities such as chronic kidney disease (CKD) and cardiovascular disease. However, to our knowledge,…
Abstract Number: 2077 • 2019 ACR/ARP Annual Meeting
Population Impact Attributable to Modifiable Risk Factors for Hyperuricemia and the Fallacy of the Variance Explained
Natalie McCormick ¹, Na Lu ², Sharan Rai ³, Chio Yokose ⁴, Yuqing Zhang ⁴ and Hyon K. Choi⁴, ¹Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Massachusetts General Hosptial, Boston, MA, ³Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, ⁴Massachusetts General Hospital, Boston, MA
Background/Purpose: In a seminal BMJ paper (Prior 1986), the Tokelau Island migrant study for gout and hyperuricemia concluded preventive strategies to modify body mass, diet…
Abstract Number: 2837 • 2019 ACR/ARP Annual Meeting
Asymptomatic Monosodium Urate Crystal Deposition Associates with Increased Expression of Pro-Inflammatory Genes
Gabriela Sandoval-Plata¹, Kevin Morgan ², Tamar Guetta-Baranes ², Ana Valdes ³, Michael Doherty ⁴ and Abhishek Abhishek ⁵, ¹Human Genomics and Molecular Genetics, School of Life Sciences, University of Nottingham / Academic Rheumatolog, School of Medicine, University of Nottingham, Nottingham, England, United Kingdom, ²Human Genomics and Molecular Genetics, School of Life Sciences, University of Nottingham, Nottingham, England, United Kingdom, ³Academic Rheumatology, School of Medicine, University of Nottingham / Nottingham NIHR BRC, Nottingham UK, Nottingham, England, United Kingdom, ⁴Academic Rheumatology, Division of Rheumatology,School of Medicine, University of Nottingham, Nottingham, UKArthritis Research UK Pain Centre, Nottingham, UKNational Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, UK, Nottingham, England, United Kingdom, ⁵Academic Rheumatology, School of Medicine, University of Nottingham,Nottingham,UK National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham,UK, Nottingham, England, United Kingdom
Background/Purpose: Persistent hyperuricaemia is a prerequisite for gout. However, only 10% of people with hyperuricaemia develop symptomatic gout, whereas 25-35% have asymptomatic monosodium urate (MSU)…
Abstract Number: 338 • 2019 ACR/ARP Annual Meeting
Effect of Serum Urate Lowering with Allopurinol on Blood Pressure in Young Adults
Angelo Gaffo¹, David Calhoun ², Elizabeth Rahn ¹, Suzanne Oparil ², Peng Li ², Tanja Dudenbostel ², David Redden ², Amy Mudano ², Jeffrey Foster ¹, Daniel Feig ², Stephanie Biggers ² and Kenneth Saag ¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham
Background/Purpose: The association between serum urate and hypertension continues to be a matter of controversy. Studies in adolescents provided evidence for the efficacy of urate…
Abstract Number: 345 • 2019 ACR/ARP Annual Meeting
Associations of Serum Uric Acid with Cardiovascular Disease Risk: Data from the Korea National Health and Nutrition Examination Survey
Kyong-Hee Jung¹, Seung Yun Lee ¹, Won Park ¹, Young Ju Suh ¹, Mie Jin Lim ¹, Seong-Ryul Kwon ¹, Joo-Hyun Lee ² and Young Bin Joo ³, ¹Inha University Hospital, Incheon, Republic of Korea, ²Inje University Ilsan Paik Hospital, Goyang, Republic of Korea, ³St. Vincent’s Hospital, Seoul, Republic of Korea
Background/Purpose: The cardiovascular risk of gout is already well known, and the debate over the cardiovascular risk of uric acid lower agents is currently hot.…
Abstract Number: 352 • 2019 ACR/ARP Annual Meeting
Primary Hyperparathyroidism Is Associated with a Higher Level of Serum Uric Acid: A Systematic Review and Meta-analysis
Ben Ponvilawan ¹, Nipith Charoenngam ¹ and Patompong Ungprasert², ¹Mahidol University, Bangkok, Thailand, ²Cleveland Clinic, Cleveland, OH, Bangkok, Thailand
Background/Purpose: Studies have suggested that primary hyperparathyroidism could be a risk factor for hyperuricemia although the results were inconsistent across the studies. This systematic review…
Abstract Number: 357 • 2019 ACR/ARP Annual Meeting
Longitudinal Variation in Repeat Serum Urate Levels: Relationship with Hyperuricemia Classification
Andrew Shaffer¹, Elizabeth Rahn ², Kenneth Saag ², Amy Mudano ³ and Angelo Gaffo ², ¹University of Alabama at Birmingham, Vestavia, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham
Background/Purpose: Previous studies have noted significant variation in serum urate (sUA) levels, and it is unknown how this influences the accuracy of hyperuricemia classification based…
Abstract Number: 366 • 2019 ACR/ARP Annual Meeting
Serum Uric Acid Level and Subclinical Coronary Atherosclerosis in Asymptomatic Individuals: An Observational Cohort Study
Doo-Ho Lim¹, Gyung-Min Park ², Seung Won Choi ³, Su Jin Choi ⁴, So Hye Nam ⁵, Seokchan Hong ⁴, Yong-Gil Kim ⁴, Chang-Keun Lee ⁴ and Bin Yoo ⁴, ¹Division of Rheumatology, Department of Internal Medicine, Ulsan University Hospital, Ulsan, Republic of Korea, ²Ulsan University hospital, Ulsan, Republic of Korea, ³Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea, Ulsan, Republic of Korea, ⁴Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea, ⁵Asan Medical Center, Seoul, Republic of Korea
Background/Purpose: High serum uric acid (SUA) level is the main prerequisite for gout, and it might be associated with obesity, hypertension, glucose intolerance, insulin resistance,…
Abstract Number: 1215 • 2019 ACR/ARP Annual Meeting
A Multicenter, Randomized, Double-blind, Placebo-controlled, Dose-Ranging Study to Evaluate Efficacy and Tolerability of SHR4640 in Patients with Hyperuricemia
Yanwei Lin¹, Xiaoxiang Chen ², Ping Ye ¹, Wenqin Geng ¹, Rui Ning ³, Yanfei Tai ³ and Chunde Bao ⁴, ¹Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China (People's Republic), ²Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of medicine, Shanghai, China (People's Republic), ³Jiangsu Hengrui Medicine Co., Ltd, Shanghai, China (People's Republic), ⁴Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of medicine, Shanghai, Shanghai, China (People's Republic)
Background/Purpose: Hyperuricemia, a common metabolic disorder, predisposes patients to develop gout due to the deposition of insoluble urate in joints. Safety concerns are frequently raised…