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Abstract Number: 2557

Are We over-Treating with Nsaids Our Early Axial Spa Patients? Results from the DESIR Cohort

Anna Moltó1,2, Benjamin Granger3, Daniel Wendling4, Maxime Dougados5 and Laure Gossec6, 1GRC-UPMC 08 (EEMOIS); UPMC Univ Paris 06.AP-HP, Pitié Salpêtrière Hospital, Department of Rheumatology, Paris, France., Paris, France, 2Paris Descartes University, Rheumatology Department, Cochin Hospital, AP-HP. INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France., Paris, France, 3Biostatistics - GRC08-EEMOIS, Université Pierre et Marie Curie - Paris 6 ; AP-HP, Paris, France, 4Service de Rhumatologie, CHU J Minjoz, Besancon, France, 5INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France., Paris, France, 6Rheumatology, UPMC GRC08, Paris 06 University, Pitié Salpétrière Hospital, Paris, France

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: Spondylarthritis

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Session Information

Session Title: Spondyloarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment III

Session Type: Abstract Submissions (ACR)

Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are the keystone in the treatment of axial Spondyloarthritis (axSpA), and even in early forms, patients symptoms may lead to an over-treatment by NSAIDs. However, the current recommendation is to use NSAIDs at the lowest efficacious dose for the shortest period of time, due to safety issues (cardiovascular and gastro-intestinal side effects). The aim of our study was to describe the real-life NSAID use in an observational cohort of inflammatory back pain suggestive of axial SpA over a 3 years period of follow-up.

Methods: Study design: Observational prospective, multi-centre study (DESIR cohort) of patients with early inflammatory back pain (IBP) suggestive of ax-SpA. Patients: Patients who attended all 6 visits (every 6 months during the fist 2 years and yearly at 3 years) and for whom NSAID information was available were included in this analysis. Data collected at every visit over 3 years: NSAID intake and ASAS-NSAID intake score for the 6 months preceding the visit. The ASAS-NSAID intake score reflects the overall intake of NSAID during a period and ranges from 0 to 200 or more (where a 100 =150 mg of Diclofenac/day every day of the period of interest); “highly doses” were defined as score > 75. Statistical analysis: descriptive analysis of the NSAID intake (as a binary variable “NSAID intake during the last 6 months” yes/no, and as a continuous variable by the ASAS-NSAID intake score for the last 6 months). Variation of the ASAS-NSAID score over time was tested by analysis of variance (ANOVA).

Results: 627 patients (46.1% males, mean age 33.7(8.7)) were assessed. 181 (28.9%) patients received a least one TNF alpha blocker during follow-up. At inclusion, 582 patients (92.8%) patients were taking NSAIDs; this proportion decreased over time, with the lowest proportion being 70.2% at 18 months. At all visits, more than 70% patients were treated with NSAIDs. Median ASAS-NSAID intake score was 36 (13-72) at inclusion, and substantially decreased to reach 7 (0-44) after 3 years (p<0.0001) (Figure) “Highly treated” patients represented 10% of the population at inclusion, and 4% after 3 years, with only 3 patients with a sustained score > 100 over time.

Conclusion: more than 70% of this early axSpA population received an NSAID treatment over the 3-years of follow-up, but intake significantly decreased over time, with only very few “highly treated” patients. This suggests that rheumatologists do not over-treat early axSpA patients with NSAIDS. Further studies should focus on those patients with sustained high doses of NAIDS over time.


Disclosure:

A. Moltó,
None;

B. Granger,
None;

D. Wendling,
None;

M. Dougados,
None;

L. Gossec,
None.

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