ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1365

ARE Erosions a Disappearing Feature in Rheumatoid Arthritis (RA)?Joint Damage in Patients with EARLY RA at 10 YEARS after Diagnosis

Juha Asikainen1, Kalevi Kaarela2, Heidi Mäkinen3, Hannu Kautiainen4, Pekka Hannonen5, Tuomas Rannio6 and Tuulikki Sokka1, 1Jyvaskyla Central Hospital, Jyväskylä, Finland, 2Jyväskylä Central Hospital, Jyväskylä, Finland, 3Tampere University Hospital, Tampere, Finland, 4Medcare Oy, Äänekoski, Finland, 5Jyväskylä Central Hospital, Jyvaskyla, Finland, 6Kuopio University Hospital, Kuopio, Finland

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: outcomes, radiography and rheumatoid arthritis (RA)

  • Tweet
  • Email
  • Print
Session Information

Session Title: Rheumatoid Arthritis - Clinical Aspects (ACR): Comorbidities, Treatment Outcomes and Mortality

Session Type: Abstract Submissions (ACR)

Background/Purpose:

Treatment of rheumatoid arthritis (RA) has improved during the last decade. Also importance of regular monitoring has been emphasized. Our objective was to study the extent of radiographic joint damage in an early RA cohort at 10 years after diagnosis.

Methods:

Our early RA cohort includes 990 patients from a single clinic with a clinical diagnosis of early RA in 1997 – 2004. Radiographs of hands and feet were taken at a 10 year follow-up visit and were analyzed according to the Larsen score (0-100) including MCP I-V, wrists, and MTP II-V. Patients were treated with the T2T strategy by a multidisciplinary care for 2 years with follow-up visits at 5 and 10 years.

Results:

Baseline characteristics of 990 patients were: the mean (SD) age 57(16) years, 67% female, 61% seropositive (RF/CCP+ any time over 10 years) and median (IQR) duration of symptoms before diagnosis 6(3, 12) months; 657(66%) patients were available for a 10 year follow up. Reasons for non-attendance among 333 patients included death (52%), high age, multi-comorbidity or institutionalization (10%), moving from the area (12%); 8% declined, 4% were lost to follow-up and 14% miscellaneous reasons. Thus, radiographs were available in 657 patients (66% seropositive); serology of one patient was missing.

At 10 years, erosions were present in 48% (314/656) patients including 61%(266/435) seropositive and 22% (48/221) seronegative patients. Among seropositive patients, Larsen score was >=10% of theoretical maximum in 28%(121/435) patients, <10% of max in 33%(145/435) patients, and 39% (169/435) remained non/erosive; for seronegative patients the corresponding figures were 5%(11/221), 17%(37/221) and 78%(173/221), respectively.  The mean (SD) and median (IQR) Larsen score in seropositive patients was 7.8 (11) and  4.0 (1.0, 10), and in seronegative patients 2.0 (4.0) and 0 (0. 3). In seropositive patients, the 10-years Larsen score declined over time while in seronegative patients erosiveness remained low and stabile (figure).

Over 10 years, all patients had been taking csDMARDs, 83% had been taking systemic glucocortikoids, and 20% bDMARDs.

Conclusion:

Larsen score remained low over 10 years and erosion rates decreased over time.

Paper_41174_abstract_47951_0

Figure. Larsen score (0-100) in seropositive and negative patients with early RA diagnosed 1997-2004 at 10 years after diagnosis. Mean with bootstrap type 95 per cent confidence intervals


Disclosure:

J. Asikainen,
None;

K. Kaarela,
None;

H. Mäkinen,
None;

H. Kautiainen,
None;

P. Hannonen,
None;

T. Rannio,
None;

T. Sokka,
None.

  • Tweet
  • Email
  • Print

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/are-erosions-a-disappearing-feature-in-rheumatoid-arthritis-rajoint-damage-in-patients-with-early-ra-at-10-years-after-diagnosis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2022 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies