ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1790

An Unmet Need for Oral Ulcer Activity in Patients with Behcet’s Disease: A Multi-National Study

Gonca Mumcu1, Adebowale Adesanya2, Aysun Aksoy3, Joice Moraes Faria M Belem4, Natalia Borges Cardin4, Fatma Alibaz-Oner5, Tulin Ergun6, Nevsun Inanc7, Alexandre W.S. Souza8, Wafa Madanat9, Farida Fortune10 and Haner Direskeneli7, 1Department of Health Management, Marmara University, Faculty of Health Sciences, Istanbul, Turkey, 2Barts and The London, School of Medicine and Dentistry, Institute of Dentistry, Clinical and Diagnostic Oral Sciences, London, UK, London, United Kingdom, 3Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, 4Rheumatology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 5Şerifali mahallesi İbrahim Hakkı sokak. Lavella 4 sitesi. B blok, D:22 Umraniye, Şerifali mahallesi İbrahim Hakkı sokak. Lavella 4 sitesi. B blok, D:22 Umraniye, Istanbul, Turkey, 6Department of Dermatology, Faculty of Medicine, Marmara University, Istanbul, Turkey, 7Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, 8Rheumatology Division, Universidade Federal de São Paulo, Sao Paulo, Brazil, 9Jordan’s Friends of Behcet’s disease Patients Society, Medical department, Amman, Jordan, Amman, Jordan, 10Dental Institute, Barts and The London NHS Trust, London, United Kingdom

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Behcet's syndrome

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Monday, October 22, 2018

Session Title: Vasculitis Poster II: Behҫet’s Disease and IgG4-Related Disease

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Efficacy of current management approaches for oral ulcer treatment in routine clinical practice is insufficiently explored in Behcet’s disease (BD) patients. The aim of this multi-national study was to assess whether an unmet need for oral ulcer activity is present in patients with Behçet’s disease.

Methods: Behçet’s disease (n=197) patients from Jordan (n=50), Brazil (n=46), United Kingdom (n=41) and Turkey (60)(F/M: 100/97, mean age: 40,7±11,6 years) were included in this cross-sectional study. Data were collected by a questionnaire regarding oral ulcer activity during the previous month, treatment protocols and smoking patterns. Transformed BDCAF score was used to evaluate the general disease activity during the last month.

Results: In the whole BD group, 41,1% (n=81) of patients were treated with non-immunosuppresive medications (non-IS) and 53,3% (n=105) by ISs, irregular medication use/no medication was observed in 5,6% (n=11). The number and healing time of oral ulcers were 3,3±3,2 and 6,5±4,6 days, respectively in patients with active oral ulcers (n=114, 57,9%). The number of oral ulcers were significantly higher in patients treated with non-IS medications (4,04±3,9) and non-smoker patients (3,6±3,4) than those treated with ISs (2,5±2,1) and current smokers (2,3±2,1)(p<0.0001 and p=0.021, respectively). In binary logistic regression, non-IS medication use was found to be a predictive factor for oral ulcer activity (OR:2,3; p=0.011). Transformed BDCAF score was also lower in patients treated with ISs (4,02±3.5) than those using a non-IS treatment protocol (6,6±3,1)(p=0.009).

Conclusion: Since oral ulcer activity and global activity assessed by BDCAF were higher in patients treated with non-IS medications, an ‘unmet need’ was observed with milder, non-IS-based treatment protocols in a multi-national setting of clinical practice in BD patients.


Disclosure: G. Mumcu, None; A. Adesanya, None; A. Aksoy, None; J. M. F. M. Belem, None; N. Borges Cardin, None; F. Alibaz-Oner, None; T. Ergun, None; N. Inanc, None; A. W. S. Souza, None; W. Madanat, None; F. Fortune, None; H. Direskeneli, None.

To cite this abstract in AMA style:

Mumcu G, Adesanya A, Aksoy A, Belem JMFM, Borges Cardin N, Alibaz-Oner F, Ergun T, Inanc N, Souza AWS, Madanat W, Fortune F, Direskeneli H. An Unmet Need for Oral Ulcer Activity in Patients with Behcet’s Disease: A Multi-National Study [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/an-unmet-need-for-oral-ulcer-activity-in-patients-with-behcets-disease-a-multi-national-study/. Accessed January 20, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/an-unmet-need-for-oral-ulcer-activity-in-patients-with-behcets-disease-a-multi-national-study/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.