Date: Monday, October 22, 2018
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Efficacy of current management approaches for oral ulcer treatment in routine clinical practice is insufficiently explored in Behcet’s disease (BD) patients. The aim of this multi-national study was to assess whether an unmet need for oral ulcer activity is present in patients with Behçet’s disease.
Methods: Behçet’s disease (n=197) patients from Jordan (n=50), Brazil (n=46), United Kingdom (n=41) and Turkey (60)(F/M: 100/97, mean age: 40,7±11,6 years) were included in this cross-sectional study. Data were collected by a questionnaire regarding oral ulcer activity during the previous month, treatment protocols and smoking patterns. Transformed BDCAF score was used to evaluate the general disease activity during the last month.
Results: In the whole BD group, 41,1% (n=81) of patients were treated with non-immunosuppresive medications (non-IS) and 53,3% (n=105) by ISs, irregular medication use/no medication was observed in 5,6% (n=11). The number and healing time of oral ulcers were 3,3±3,2 and 6,5±4,6 days, respectively in patients with active oral ulcers (n=114, 57,9%). The number of oral ulcers were significantly higher in patients treated with non-IS medications (4,04±3,9) and non-smoker patients (3,6±3,4) than those treated with ISs (2,5±2,1) and current smokers (2,3±2,1)(p<0.0001 and p=0.021, respectively). In binary logistic regression, non-IS medication use was found to be a predictive factor for oral ulcer activity (OR:2,3; p=0.011). Transformed BDCAF score was also lower in patients treated with ISs (4,02±3.5) than those using a non-IS treatment protocol (6,6±3,1)(p=0.009).
Conclusion: Since oral ulcer activity and global activity assessed by BDCAF were higher in patients treated with non-IS medications, an ‘unmet need’ was observed with milder, non-IS-based treatment protocols in a multi-national setting of clinical practice in BD patients.
To cite this abstract in AMA style:Mumcu G, Adesanya A, Aksoy A, Belem JMFM, Borges Cardin N, Alibaz-Oner F, Ergun T, Inanc N, Souza AWS, Madanat W, Fortune F, Direskeneli H. An Unmet Need for Oral Ulcer Activity in Patients with Behcet’s Disease: A Multi-National Study [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/an-unmet-need-for-oral-ulcer-activity-in-patients-with-behcets-disease-a-multi-national-study/. Accessed April 8, 2020.
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