Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: This study aimed to analyze the 99mTc-HDP scintigraphic features in hand-arm vibration syndrome (HAVS) and to compare with primary Raynaud’s phenomenon (RP) and secondary RP associated with connective tissue disease (CTD).
Methods: 99mTc-HDP digital blood flow and pool scintigraphy were performed in 59 patients with primary RP, 73 patients with HAVS-related RP and 38 patients with CTD-related RP, and clinical features were collected by a retrospective review of medical records. We calculated 6 ratios by using the time-activity curve and static blood pool images; the chilled to ambient hand and wrist ratios of the first peak height, the initial slope, and blood pool uptake. We analyzed 4 morphologic characteristics: an initial spike curve, a slow progress pattern, paradoxically increased uptake pattern in the time-activity curve and the inhomogeneous radioactivity uptake in the blood pool image.
Results: All 73 patients with HAVS-related RP were mine workers. The onset duration of RP after exposure to vibration was 21.8±7.3 years with 6.3±7.0 years of vibration exposure time. The chilled to ambient hand ratios of the first peak height and the initial slope were significantly lower in patients with HAVS-related occupational RP, compared to patients with primary RP. The presence of paradoxically increased uptake pattern of hand was significantly lower in HAVS compared to primary RP.
Conclusion: There were significant differences of both quantitative and morphologic characteristics of 99mTc-HDP scintigraphy between primary RP and HAVS. The results suggest that each disease might have quite different pathophysiology and thus different criteria should be applied to evaluation of each RP. Determination of separate cut off values for 99mTc-HDP scintigraphy is necessary to establish the accurate diagnosis of HAVS.
To cite this abstract in AMA style:Lee KA, Jeong HW, Lee SH, Kim HR. 99mtc-Hdp Digital Blood Flow Scintigraphy for Assessment of Raynaud Phenomenon Associated with Hand-Arm Vibration Syndrome [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/99mtc-hdp-digital-blood-flow-scintigraphy-for-assessment-of-raynaud-phenomenon-associated-with-hand-arm-vibration-syndrome/. Accessed June 15, 2021.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/99mtc-hdp-digital-blood-flow-scintigraphy-for-assessment-of-raynaud-phenomenon-associated-with-hand-arm-vibration-syndrome/