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Abstracts tagged "Raynaud’s phenomenon"

  • Abstract Number: 1392 • ACR Convergence 2020

    Long-Term Tolerability of Aminaphtone in Raynaud’s Phenomenon Secondary to Systemic Sclerosis

    Alberto Sulli1, Sabrina Paolino1, Giorgia Ferrari1, Carmen Pizzorni1, Elvis Hysa1, Maurizio Cutolo1 and Emanuele Gotelli1, 1Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic, Genoa, Italy

    Background/Purpose: Aminaphtone has been used for many years to treat microvascular disorders. In vitro Aminaphtone counteracts vasoconstriction downregulating endothelin-1 production and interferes with adhesion molecules…
  • Abstract Number: 1396 • ACR Convergence 2020

    Digital Artery Volume Index (Davix©) Predicts Onset of Future Digital Ulcers in Patients with Systemic Sclerosis

    Klodian Gjeloshi1, Giovanni Lettieri2, Fiammetta Danzo1, Giuseppina Abignano3, Mark Hinton4, Anne-Maree Dean5, Giovanna Cuomo6, Olga Kubassova7 and Francesco Del Galdo5, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK and Internal Medicine Department, University of Campania Luigi Vanvitelli, Naples, Italy, Leeds, United Kingdom, 2Radiology Department, San Carlo Hospital, Potenza, Italy, Potenza, Italy, 3Rheumatology Institute of Lucania (IReL), Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, England, United Kingdom, 4IAG CEO, London, United Kingdom, London, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom, 6Internal Medicine Department, University of Campania Luigi Vanvitelli, Naples, Italy, Naples, Italy, 7Image Analysis Group, London, United Kingdom

    Background/Purpose: Neointima proliferation is a key pathologic feature of Systemic Sclerosis (SSc), causing arterial vessel narrowing. It is a recognised culprit pathological lesion in Digital…
  • Abstract Number: 149 • 2019 ACR/ARP Annual Meeting

    Teaching Rare Diseases Through Role Play: Results of an Experimental Workshop About Raynaud Phenomenon

    Sébastien Sanges1, Sandrine Morell-Dubois 2, Meryem-Maud Farhat 3, Morgane Assaraf 3, Marc LAMBERT 4, Vincent Sobanski 3, David Launay 3 and Eric Hachulla 5, 1CHRU Lille, Lille, France, 2Department of Internal Medicine and Clinical Immunology, CHU Lille, University of Lille, Lille, France, 3CHU Lille, Lille, France, 4Lille University Hospital, Lille, France, 5Dept. of Internal Medicine and Clinical Immunology, Hôpital Claude Huriez, University of Lille, Lille, France, Lille, France

    Background/Purpose: Systemic autoimmune diseases are mostly taught through theoretical lectures, which do not allow for the acquisition of physical examination skills and semiologic confrontation. We…
  • Abstract Number: 868 • 2019 ACR/ARP Annual Meeting

    The Effect of Atorvastatin on Microvascular Endothelial Function and Raynaud Phenomenon in Early Diffuse Scleroderma: Results of the “Tamer”‘ Study

    Robyn Domsic1, Maureen Laffoon 1, Balasubramani Goundappa 2, Thomas Medsger 1, Robert Lafyatis 1 and Steven Wisniewski 1, 1University of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh Epidemiology Data Center, Pittsburgh, PA

    Background/Purpose: Statins have pleiotropic effects felt to influence in their beneficial cardiovascular effects.  These include increased nitric oxide production and improved endothelial function, modulation of…
  • Abstract Number: 1635 • 2019 ACR/ARP Annual Meeting

    Correlation Between Raynaud’s Condition Score, Nailfold Videocapillaroscopy and Laser Speckle Contrast Analysis in Secondary Raynaud’s Phenomenon Due to Systemic Sclerosis

    Barbara Ruaro1, Elisa Alessandri 2, Massimo Ghio 3, Carmen Pizzorni 4, Sabrina Paolino 4, Andrea Casabella 5, Antonio De Tanti 6, Alberto Sulli 7 and Maurizio Cutolo 8, 11 Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy; 2 Cardinal Ferrari Centre, S. Stefano Rheabilitation, Fontanellato (Parma), Italy, Genoa, Italy, 21. Research Laboratory and Academic Division of the Clinical Rheumatology Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, 3Research Laboratory and Academic Division of the Clinical Rheumatology Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, 4Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, 51 Research Laboratory and Academic Division of the Clinical Rheumatology Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, 62 Cardinal Ferrari Centre, S. Stefano Rheabilitation, Fontanellato (Parma), Italy, Fontanellato, Italy, 7Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy, 8Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy

    Background/Purpose: To evaluate any correlation between the Raynaud's Condition Score (RCS) and the morphological and functional methods available to evaluate microvascular damage in systemic sclerosis (SSc) patients (1-4). Methods: Sixty-six…
  • Abstract Number: 2598 • 2019 ACR/ARP Annual Meeting

    Different Treatment Backgrounds Do Not Influence Aminaphtone Efficacy in Primary and Secondary Raynaud’s Phenomenon

    Alberto Sulli1, Federica Goegan 2, Emanuele Gotelli 2, Massimo Patane' 3, Carmen Pizzorni 3, Sabrina Paolino 3, Elisa Alessandri 4 and Barbara Ruaro 5, 1Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy, 2Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Genoa, Italy, 3Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, 4Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genova, 51 Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy; 2 Cardinal Ferrari Centre, S. Stefano Rheabilitation, Fontanellato (Parma), Italy, Genoa, Italy

    Background/Purpose: Aminaphtone treatment improves clinical symptoms of Raynaud's phenomenon (RP) and increases peripheral blood perfusion (BP) in patients with either primary or secondary RP (1-2).The…
  • Abstract Number: 1730 • 2018 ACR/ARHP Annual Meeting

    A Role for Duplex Ultrasound of Hand Arteries in the Assessment of the Vasculopathy Associated to Systemic Sclerosis-like Diseases

    Silvia Pérez Esteban1, Esperanza Naredo Sánchez1, Sheila Recuero Díaz1, Fredeswinda I. Romero-Bueno2, Gabriel Herrero-Beaumont3 and Olga Sanchez-Pernaute4, 1Rheumatology, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, 2Section for Autoimmune Diseases, Rheumatology, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, 3Bone and Joint Research Unit, Fundación Jiménez Díaz University Hospital & Health Research Institute, Madrid, Spain, 4Rheumatology Division. Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain

    Background/Purpose: Small vessel arteriopathy precedes the development of organ damage and tissue fibrosis in systemic sclerosis (SSc) and related disorders. It is currently considered that…
  • Abstract Number: 1879 • 2018 ACR/ARHP Annual Meeting

    The Effects of Riociguat on Raynaud’s Phenomenon and Digital Ulcers in Patients with Diffuse Systemic Sclerosis: Results from the Phase IIb RISE-SSc Study

    Dinesh Khanna1, Yannick Allanore2, Christopher P. Denton3, Masataka Kuwana4, Marco Matucci-Cerinic5, Janet E. Pope6, Janethe Pena7, Kaisa Laapas8, Zhen Yao9 and Oliver Distler10, 1Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 2Rheumatology A Department, Cochin Hospital, Paris Descartes University, Sorbonne Paris Cité, Paris, France, 3UCL Division of Medicine, Royal Free Campus, London, United Kingdom, 4Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 5Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 6Department of Medicine, University of Western Ontario, London, ON, Canada, 7Clinical Development, Bayer US LLC, Whippany, NJ, 8StatFinn Oy, Espoo, Finland, 9Bayer AG, Berlin, Germany, 10Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of pulmonary arterial hypertension associated with connective tissue disease. It was anticipated that…
  • Abstract Number: 2692 • 2018 ACR/ARHP Annual Meeting

    High Frequency Ultrasound As a Novel Approach to Quantifying the Digital Microangiopathy of Systemic Sclerosis

    Victoria Flower1,2, Shaney Barratt3,4, Darren Hart5, Amanda MacKenzie2, Jacqueline Shipley5, Stephen Ward2 and John Pauling1,2, 1Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Foundation Trusts, Bath, United Kingdom, 2Centre for Therapeutic Innovations & Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, 3North Bristol NHS Trust, Bristol, United Kingdom, 4Academic Respiratory Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, 5Clinical Measurement Department, Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Foundation Trusts, Bath, United Kingdom

    Background/Purpose: Structural and functional vascular abnormalities occur in Systemic Sclerosis (SSc). We report on the use of High Frequency Ultrasound (HFUS) with Superb Microvascular Imaging…
  • Abstract Number: 2701 • 2018 ACR/ARHP Annual Meeting

    Botulinum Toxin in the Management of Raynaud’s Phenomenon

    Daniel Ennis1,2, Zareen Ahmad3, Keshini Devakandan1, Melanie A Anderson4 and Sindhu Johnson1, 1Toronto Scleroderma Program, Mount Sinai Hospital, Toronto Western Hospital, Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada, 2Rheumatology, University of British Columbia, Vancouver, BC, Canada, 3Toronto Scleroderma Program, Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 4University Health Network Library Services, Toronto General Hospital, Toronto, ON, Canada

    Background/Purpose: The objectives of this study were to evaluate the effectiveness and safety of botulinum toxin injection in Raynaud’s phenomenon. Methods: Medline and Embase databases…
  • Abstract Number: 1704 • 2017 ACR/ARHP Annual Meeting

    Non-Randomized Controlled Trial to Evaluate the Effect of Extracorporeal Shock Wave Therapy on Digital Ulcers in Systemic Sclerosis

    Tomonori Ishii1, Yasushi Kawaguchi2, osamu ishikawa3, naruhiko takasaawa4, takao kodera5, hidekata yasuoka6, yuichi takahashi7, osamu takai8, Izaya Nakaya9, Hiroshi Fujii10, Yukiko Kamogawa10, Yuko Shirota10, Tsuyoshi Shirai10, Yoko Fujita11, shinichiro saito12, Hiroaki Shimokawa13 and Hideo Harigae10, 1Clinical Research, Innovation and Education Center, Tohoku University Hospital, Sendai, Japan, 2Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 3Department of Dermatology, Gunma University Graduate School of Medicine, gunma, Japan, 4Department of Internal Medicine, Tohoku Medical and Pharmaceutical University Wakabayashi Hospital, Sendai, Japan, 5Division of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, Sendai, Japan, 6Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, tokyo, Japan, 7Yu Family Clinic, Sendai, Japan, 8Osaki Citizen Hospital, Sendai, Japan, 9Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Morioka, Japan, 10Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan, 11Department of Hematolgy and Rheumatolgy, Tohoku University Graduate School of Medicine, Sendai, Japan, 12IMS Meirikai Sendai General Hospital, Sendai, Japan, 13Department of Cardiovascular medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

    Background/Purpose: Patients with systemic sclerosis (SSc) often display Raynaud’s phenomenon, which causes digital skin ulcers. Since these ulcers are not associated with autoimmune factors, conventional…
  • Abstract Number: 2096 • 2017 ACR/ARHP Annual Meeting

    Nailfold Capillaroscopy Is an Opportunity for Telerheumatology

    Jacob R. Stever1, Nicholas Lebedoff2, Tracy M. Frech3, Lesley A. Saketkoo4 and Marcus Snow5, 1Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 2Internal Medicine, University of Utah, Salt Lake City, UT, 3Division of Rheumatology, University of Utah, Salt Lake City, UT, 4Rheumatology, Tulane University School of Medicine, New Orleans, LA, 5Internal Medicine, University of Nebraska, Omaha, NE

    Background/Purpose: The 2013 classification criteria for systemic sclerosis (SSc) provide 2 points (towards a 9 point diagnosis) for patients who have abnormal capillaroscopy. In the…
  • Abstract Number: 2168 • 2017 ACR/ARHP Annual Meeting

    Dissociation of FVC and Dlco in Patients with Dermatomyositis and Polymyositis

    Eun Hye Park1, Woo Chang Hwang2, Eun Young Lee1, Eun Bong Lee1, Yeong Wook Song3 and Jin Kyun Park1, 1Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 2Department of Statistics, Data Science for Knowledge Creation Research Center, Seoul National University, Seoul, Korea, Republic of (South), 3Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Korea, Republic of (South)

    Background/Purpose: Interstitial lung disease in patients with polymyositis (PM) and dermatomyositis (DM) is characterized by decrease in both lung compliance and pulmonary vascularity, leading to…
  • Abstract Number: 2697 • 2017 ACR/ARHP Annual Meeting

    Systemic Sclerosis Quality of Life Questionnaire (SScQoL) Captures the Complex Problems Experienced By Patients with Scleroderma

    Matylda Sierakowska1, Stanislaw Sierakowski2, Marzena Olesinska3, Marek Brzosko4, Piotr Leszczynski5, Katarzyna Pawlak-Bus5, Bogdan Batko6, Piotr Wiland7, Maria Majdan8, Malgorzata Bykowska-Sochacka9, Wojciech Romanowski10, Aleksandra Zon-Giebel11, Slawomir Jeka12 and Mwidimi Ndosi13, 1Department of Integrated Medical Care, Medical University of Bialystok, Bialystok, Poland, 2Department of Rheumatology and Internal Diseases, Medical University of Bialystok, Poland, Bialystok, Poland, 3Department of Connective Tissue Disease, National Institute of Geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland, 4Department of Rheumatology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland, 5Department of Rheumatology and Rehabilitation, Medical University in Poznan, Poznan, Poland, 6Center of Rheumatology, J. Dietl Hospital in Krakow, Krakow, Poland, 7Department and Clinic of Rheumatology and Internal Medicine, Medical University, Wroclaw, Poland, 8Department of Rheumatology and Connective Tissue Diseases, Medical University in Lublin, Lublin, Poland, 9Dr J. Titz-Kosko Regional Hospital for Rheumatic Diseases in Sopot, Sopot, Poland, 10Poznan Centre of Rheumatology in Srem, Srem, Poland, 11Silesian Center of Rheumatology, Rehabilitation and Prevention of Disability, Ustron, Poland, 122nd University Hospital, CM UMK, Department of Rheumatology and Connective Tissue Diseases,, Bydgoszcz, Poland, 13Department of Nursing and Midwifery, University of the West of England, Bristol, United Kingdom

    Background/Purpose: Systemic sclerosis (SSc) is a chronic rheumatic disease that disturbs the patients’ biological, social, emotional spiritual, and physical functioning; resulting in reduced quality of…
  • Abstract Number: 2889 • 2017 ACR/ARHP Annual Meeting

    Aminaphtone Ameliorates Clinical Symptoms and Increases Skin Blood Perfusion in Patients with Both Primary and Secondary Raynaud Phenomenon: A Six-Month Open Study

    Alberto Sulli1, Maurizio Cutolo2, Carmen Pizzorni2, Sabrina Paolino2, Elisa Alessandri2, Emanuele Gotelli2 and Barbara Ruaro2, 1Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino, Genoa, Italy, Genova, Italy, 2Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino, Genoa, Italy, Genoa, Italy

    Background/Purpose: Current treatments for Raynaud's phenomenon (RP) have limited efficacy, which was mainly demonstrated by physician/patient reported outcomes. Aminaphtone is a vasoactive drug recently suggested…
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