ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1643

15 Year Comparative Analysis of Cardiovascular Events in Female Subjects with Lupus Versus Controls

Erika Joyce1, Kristy Huysman2, Linda Santelices2, Michael Anderson2, Amy H. Kao3, Jennifer Elliott4, Jennifer Mall2, Amy Xiaoqin Tang5 and Susan Manzi2, 1Internal Medicine, Allegheny Health Network, Pittsburgh, PA, 2Medicine, Allegheny Health Network, Pittsburgh, PA, 3EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 4Allegheny Health Network, Pittsburgh, PA, 5Lupus Center of Excellence, Allegheny Health Network Research Institute, Pittsburgh, PA

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: ,

Session Information

Date: Monday, November 6, 2017

Session Title: Systemic Lupus Erythematosus – Clinical Aspects and Treatment Poster II: Damage and Comorbidities

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: The multi-organ sequelae of systemic lupus erythematosus (SLE) may include nephritis, alveolar hemorrhage, and cardiovascular disease. Our long term follow up of female SLE subjects has documented the incidence of cardiovascular events, and the predictive nature of carotid ultrasound. To our knowledge, there is a paucity of prospective comparative data of female SLE subjects with age and race adjusted controls. Herein we compare the 15-year incidence of cardiovascular events (CVE’s) within a large prospectively followed single-institution female SLE and control subject cohort.

Methods: A cohort of women diagnosed with SLE, and a race adjusted group of controls were enrolled and prospectively followed for 15 years. Baseline CV risk factors including hypertension, diabetes, lipid panel, and Framingham risk score were assessed. Within the SLE cohort a Systemic Lupus International Collaborating Clinics (SLICC) score was recorded. CVE’s and information were collected by chart review and subject interview.

Results: A total of 267 women without previous CV events (148 with SLE , and 119 controls) were included in the analysis. A total of 52 patients had a CVE, 48 SLE patients versus 4 control patients (p<0.001). The mean time to first CVE was 11.4 yrs in SLE women and 11.7 yrs in control women. SLE diagnosis at baseline was associated with more than 9-fold increased risk for any incident CV event (p = 0.002), after adjusting for traditional Framingham risk score.

Within this SLE cohort, SLICC score was predictive of any CVE (p=0.042).

Conclusion: This comparative analysis demonstrates the increased incidence of CV events within SLE subjects. Further, the impact of SLE is independent of traditional risk factors including the Framingham risk score. This underscores the importance of proactive management of CVE risk in SLE subjects.

Disclosure: E. Joyce, None; K. Huysman, None; L. Santelices, None; M. Anderson, None; A. H. Kao, EMD Serono, Inc, 3; J. Elliott, None; J. Mall, None; A. X. Tang, None; S. Manzi, Exagen, 2,Exagen, 5,Exagen, 7,GSK, 5,UCB, 5,AstraZeneca, 6,Lupus Foundation of America, 9,AstraZeneca, 2,Human Genome Sciences/GSK, 2,Amgen, 2,Bristol-Myers Squibb, 2.

To cite this abstract in AMA style:

Joyce E, Huysman K, Santelices L, Anderson M, Kao AH, Elliott J, Mall J, Tang AX, Manzi S. 15 Year Comparative Analysis of Cardiovascular Events in Female Subjects with Lupus Versus Controls [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/15-year-comparative-analysis-of-cardiovascular-events-in-female-subjects-with-lupus-versus-controls/. Accessed February 23, 2019.

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