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  • Abstract Number: 0004 • ACR Convergence 2021

    Unappreciated Systemic Metabolic Functions of the Canonical B Cell Cytokines, BAFF and APRIL: Regulation of Lipolysis and Non-shivering Thermogenesis and Protection from Obesogenic Diet Induced Weight Gain

    Isaac Harley1, Calvin Chan2, Paul Pfluger3, Trompette Aurelien4, Traci Stankiewicz5, Jessica Allen5, Maria Moreno-Fernandez5, Michelle Damen5, Jarren Oates5, Pablo Alarcon5, Jessica Doll6, Matthew Flick7, Leah Flick8, Juan Sanchez-Gurmaches9, Rajib Mukherjee9, Rebekah Karns10, Michael Helmrath11, Thomas Inge12, Stuart Weisberg13, Sunje Pamp14, David Relman15, Randy Seeley16, Matthias Tschoep17, Chris Karp18 and Senad Divanovic8, 1University of Colorado Anschutz Medical Campus, Aurora, CO, 2University of Cincinnati, Cincinnati, OH, 3Technical University of Munich, Munich, Germany, 4Le Centre hospitalier universitaire vaudois, Lausanne, Switzerland, 5Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinnati, OH, 6Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinn, OH, 7Division of Experimental Hematology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 8Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 9Division of Endocrinology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 10Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 11Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 12Department of Surgery, Children’s Hospital Colorado, Aurora, CO, 13Columbia University Medical Center, New York, NY, USA, New York, NY, 14Danmarks Tekniske Universitet, Lyngby, Denmark, 15Department: Medicine - Med/Infectious Diseases - Stanford University, Stanford, 16Department of Surgery, Internal Medicine and Nutritional Sciences, University of Michigan, Ann Arbor, MI, 17Division of Metabolic Diseases, Technische Universität München, Munich, Germany, 18Division of Molecular Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati

    Background/Purpose: The impact of immune mediators on weight homeostasis and systemic metabolism remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative…
  • Abstract Number: 0578 • ACR Convergence 2021

    Hyperinsulinemic Diet and Increased Risk of Female Gout: 2 Prospective Cohort Studies of US Women over 30 Years

    Natalie McCormick1, Chio Yokose2, Na Lu3, Amit Joshi1 and Hyon K. Choi4, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Waltham, MA, 3Arthritis Research Canada, Vancouver, BC, Canada, 4Massachusetts General Hospital, Lexington, MA

    Background/Purpose: Gout and the metabolic (insulin resistance) syndrome frequently coexist. Intravenous insulin has been shown to raise serum urate (SU) levels in physiologic studies1 and…
  • Abstract Number: 0586 • ACR Convergence 2021

    Recommended Fiber Intake, but Not Overall Dietary Quality, Is Associated with Reduced Risk of Rheumatoid Arthritis – Results from a Nested Case-control Study

    Rebecka Bäcklund1, Isabel Drake1, Emily Sonestedt2, Jan-Åke Nilsson1, Ulf Bergström1 and Carl Turesson3, 1Lund University, Malmö, Sweden, 2Lund University, Lund, Sweden, 3Lund University, Malm, Sweden

    Background/Purpose: Diet has received attention as a factor possibly contributing to development of rheumatoid arthritis (RA). The aim of this study was to investigate the…
  • Abstract Number: 0677 • ACR Convergence 2021

    Pro-Inflammatory Diet and Increased Risk of Incident Female Gout: 30-Year Prospective Cohort Study of >170,000 Pre- and Post-Menopausal US Women

    Natalie McCormick1, Chio Yokose2, Na Lu3, Amit Joshi1 and Hyon K. Choi4, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Waltham, MA, 3Arthritis Research Canada, Vancouver, BC, Canada, 4Massachusetts General Hospital, Lexington, MA

    Background/Purpose: Globally, the prevalence of gout is rising in females more than males,1 but data on modifiable risk factors for female gout are scarce. Emerging…
  • Abstract Number: 0991 • ACR Convergence 2021

    Does Diet Affect Gout Risk Differently Among Genetically Predisposed Women?: Prospective Female Cohort Study Findings over 34 Years

    Chio Yokose1, Natalie McCormick2, Na Lu3, Amit Joshi2 and Hyon K. Choi4, 1Massachusetts General Hospital, Waltham, MA, 2Massachusetts General Hospital, Boston, MA, 3Arthritis Research Canada, Vancouver, BC, Canada, 4Massachusetts General Hospital, Lexington, MA

    Background/Purpose: Gout has long been considered a male disease. However, several recent analyses of the Global Burden of Disease (GBD) Study report a disproportionate worsening…
  • Abstract Number: 1499 • ACR Convergence 2021

    Imbalance Between T Follicular Cells and T Regulatory Cells Involved in High Fat-Diet Associated Lupus Development in MRL/lpr Mice

    Ronak Patel1, Therese Posas-Mendoza2, Juan Meng3, Xuhua Shi3, Swathi Dhulipala4, Chad Hille2, Linh Hellmers1, Robert Quinet5, William Davis6, Jerald Zakem7, Chandana Keshavamurthy1, Zongbing You3 and Xin Zhang1, 1Ochsner, New Orleans, LA, 2Ochsner Clinic Foundation, New Orleans, LA, 3Tulane University, New Orleans, LA, 4Ochsner Clinic Foundation, River Ridge, LA, 5Ochsner Health, River Ridge, LA, 6Ochsner Medical Center, New Orleans, LA, 7Ochsner Health Systems, Metairie, LA

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by persistent inflammation and production of autoantibodies, which deposit within numerous tissues leading to…
  • Abstract Number: 1647 • ACR Convergence 2021

    Interaction Effect of Systemic Inflammation and Dietary Protein Intake on Resting Energy Expenditure in Individuals with RA

    Beatriz Hanaoka1, Jing Zhao1, Kristen Heitman1, Fahad Khan1, Guy Brock1, Jeff Volek1, Wael Jarjour1 and Barbara Gower2, 1Ohio State University, Columbus, OH, 2University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: In rheumatoid cachexia (RC), high resting energy expenditure (REE) has been associated with loss of muscle mass driven by proinflammatory cytokines. The objectives of…
  • Abstract Number: 1699 • ACR Convergence 2021

    The “ITIS” Diet Improves Fatigue in Patients with Rheumatoid Arthritis and Is Associated with Changes in Metabolome and Fecal Microbiome

    Roxana Coras1, Cameron Martino1, Julia Gauglitz1, Alan Jarmusch1, Anupriya Tripathi1, Francesca Cedola2, Marta Fernandez-Bustamante1, Meritxall Agustín-Perez1, Maram Alharthi1, Susan Lee1, Abha Singh1, Soo In Choi1, Tania Rivera1, Katherine Nguyen3, Tatyana Shekhtman1, Tiffany Holt1, Shahrokh Golshan1, Rob Knight1, Pieter C Dorrestein1 and Monica Guma1, 1University of California San Diego, La Jolla, CA, 2University of California San Diego, Rome, CA, Italy, 3University of California San Diego, San Diego, CA

    Background/Purpose: Fatigue is common symptom in rheumatoid arthritis (RA), associated with decreased quality of life and productivity. Fatigue mechanisms have not been well studied, hence,…
  • Abstract Number: 0189 • ACR Convergence 2020

    Determining the Relationship Between Mycobacterium Avium Subspecies Paratuberculosis Serostatus, Dietary Habits, Medication Regimen, and Joint Pain in Patients with Rheumatoid Arthritis

    Chelsea Guan1, Shazia Majid2, Sweta Chalise2, Saleh Naser2, Robert Sharp2 and Shazia Beg3, 1University of Central Florida, Orlando, FL, 2University of Central Florida, Orlando, 3University of Central Florida College of Medicine, Orlando

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease that primarily affects synovial tissues. While the exact etiology is unknown, it is hypothesized that…
  • Abstract Number: 0654 • ACR Convergence 2020

    The Effects of Dietary Macronutrients on Serum Urate: A Secondary Analysis of the OmniHeart Trial

    Matthew Belanger1, Christina Wee1, Kenneth Mukamal1, Edgar Miller2, Frank Sacks3, Lawrence Appel2, Robert Shmerling4, Hyon Choi5 and Stephen Juraschek1, 1Beth Israel Deaconess Medical Center/Harvard Medical School, Division of General Medicine, Boston, MA, 2Johns Hopkins University, School of Medicine, Department of Medicine, Division of General Internal Medicine, Baltimore, MD, 3Harvard T. H. Chan School of Public Health, Department of Nutrition, Boston, MA, 4Beth Israel Deaconess Medical Center/Harvard Medical School, Division of Rheumatology, Mashpee, MA, 5Massachusetts General Hospital, Department of Medicine, Division of Rheumatology, Lexington, MA

    Background/Purpose: Diet is a significant determinant of hyperuricemia and risk for gout. Dietary recommendations to prevent gout emphasize reducing purine intake; however, low-purine diets are…
  • Abstract Number: 0702 • ACR Convergence 2020

    Distinct Murine Cartilage Microbial DNA Signatures Are Seen in High Fat Diet-Induced Obesity and Aging

    Christopher Dunn1, Cassandra Garman2, Jake Martin2, Vladislav Izda2, Cassandra Velasco2 and Matlock Jeffries2, 1University of Oklahoma Health Sciences Center, Oklahoma Cityq, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: The strongest nongenetic risk factors for primary knee OA are advanced age and obesity. We have previously shown a human cartilage microbial DNA signature…
  • Abstract Number: 0951 • ACR Convergence 2020

    The Comparative Effect of Exposure to Various Risk Factors on the Risk of Hyperuricaemia: Diet Has a Weak Causal Effect

    Ruth Topless1, Tanya Major1, Jose Florez2, Joel Hirschhorn3, Murray Cadzow1, Nicola Dalbeth4, Lisa Stamp5, Phillip Wilcox1, Richard Reynolds6, Joanne Cole2 and Tony Merriman1, 1University of Otago, Dunedin, New Zealand, 2Massachusetts General Hospital, Boston, 3Harvard Medical School, Boston, 4University of Auckland, Auckland, New Zealand, 5University of Otago Christchurch, Christchurch, New Zealand, 6University of Alabama Birmingham, Birmingham

    Background/Purpose: Prevention of hyperuricaemia (HU) is critical to the prevention of gout. Therefore, understanding the causal relationships and relative contributions of various risk factors to…
  • Abstract Number: 1463 • ACR Convergence 2020

    Threshold Level for Long-term Healthy Diet Adherence to Reduce the Risk of Rheumatoid Arthritis Among Women in a Prospective Cohort Using a Marginal Structural Model Approach

    Nathalie Marchand1, Yu-Han Chiu2, Kazuki Yoshida3, Susan Malspeis4, Jeffrey Sparks5, Karen Costenbader6, Elizabeth Karlson1 and Bing Lu7, 1Brigham and Women's Hospital, Boston, MA, 2Harvard T.H. Chan School of Public Health, Boston, MA, 3Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 4Brigham and Women's Hospital, Boston, 5Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 6Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 7Brigham and Women's Hospital and Harvard Medical School, Newton, MA

    Background/Purpose: Previous analyses in the Nurses’ Health Study (NHS) cohorts have shown that eating a healthier diet, as measured by the Alternative Healthy Eating Index…
  • Abstract Number: 1607 • ACR Convergence 2020

    Effectiveness of Dietary Counseling on Gout Management and Risk Factors for Metabolic Syndrome in Gout Patients

    Juliana Chang1, Jonathan Tsui2 and Maida Wong3, 1Division of Rheumatology, Department of Medicine, University of California Irvine, Irvine, CA, 2Geisinger Medical Center, Danville, PA, 3Division of Rheumatology, Department of Medicine, VA Long Beach Healthcare System, Long Beach, CA

    Background/Purpose: Gout is the most prevalent inflammatory arthritis globally. Despite treatment advances, the prevalence of gout has continued to increase over the last several decades.…
  • Abstract Number: 1647 • ACR Convergence 2020

    An Oleuropein-based Dietary Supplement Improves Joint Function in Older People with High Knee Joint Pain

    Marie-Noelle Horcajada1, Maurice Beaumont2, Nicolas Sauvageot2, Madleen Saboundjian1, Laure Poquet1, Anne-Christine Hick3, Berenice Costes4 and Yves Henrotin5, 1Nestle Research, EPFL Innovation Park, Lausanne, Switzerland, 2Nestle Research, Clinical Development Unit, Lausanne, Switzerland, 3Artialis SA, Liège, Belgium, 4Artialis SA, Liege, Belgium, 5University of Liège, Liège, Belgium

    Background/Purpose: The aim of this study was to investigate the effects of a 6-month intervention with an Olive Leaf Extract (OLE) standardized for oleuropein content…
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