Background/Purpose
Behçet’s Disease (BD) is a systemic vasculitis that predominantly presented with oral aphtous ulcers and additionally at least two of the following findings like genital ulcers, eye involvement, skin lesions and pathergy reaction. Vascular involvement is devastating face of BD and thrombosis of the arterial and venous system and aneurismatic arterial disease is not rare. The flares are the typical nature of BD and the pathology of the disease is mostly constructed on vasculitis. However the satisfied mechanism of BD remains unknown. We herein tried to evaluate the micro RNA (miRNA) behavior in BD.
Methods
Eighty-five BD patients were enrolled in to the study group, which were divided to 3 groups of 20-20 and 25 with active vascular disease, active mucocutaneous disease and patients with at least 6 months remission, respectively. Additional 25 volunteers were the healthy controls and the 4 of the groups have no difference in the characteristics. The whole study population was male, due to difficulties of finding active women BD patients. Serum samples were analyzed for miRNA with PCR assay and the data were analyzed statistically. Active vascular patients had significantly higher CRP and ESR results than active mucocutaneous ones and they both had significantly higher levels than remission and healthy groups.
|
|
Active vasculer BD |
Active mucocutaneous BD |
Remission BD |
Healthy controls |
|
Age |
32.60±4.57 |
32.60±6.36 |
35.72±9.21 |
32.20±1.71 |
|
Disease duration |
4.30±2.71 |
4.25±3.31 |
4.68±3.21 |
|
|
CRP (mg/l) |
29.35±36.47 |
22.53±21.38 |
4.92±3.11 |
3.1±1.8 |
|
ESR (/hour) |
34.90±26.46 |
30.0±24.03 |
15.56±11.85 |
10.02±4.21 |
Results
There was no difference for any miRNA between BD patients with remission and healthy controls. The comparison of active BD patients and healthy controls revealed lower levels of miR-17-5p, miR-451A, miR-106b-5p, miR-16-5p, miR-19b-3p, miR-26b-5p, miR-93-5p, miR-20b, miR-25-3p in the disease activity. miR26b-5p was found lower only in mucocutaneous group inspite of vasculars.
Conclusion
The miRNA profile of active BDs especially the vascular group was remarkable. These miRNAs were related mainly with T and B lymphocytes and some apoptotic genes. miRNA studies might be beneficial for detecting better targets for treating the disease in the future.
Disclosure:
A. M. Onat,
None;
O. Gerenli,
None;
B. Kisacik,
None;
M. Ulasli,
None;
G. Kimyon,
None;
Y. Pehlivan,
None;
S. Oztuzcu,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/mi-rna-profile-of-active-vascular-behcets-patients/