Session Information
Session Type: Abstract Submissions (ACR)
Background/Purpose:
The objective of this study was to compare psychological status and sleep quality between the patients with AS patients and healthy controls, and to discover the correlation between anxiety, depression and sleep disturbances, to evaluate the associated factors of disease specific variables in AS patients and to detect independent factors contributing to psychological variables.
Methods:
A nationwide face-to-face epidemiological investigation was performed in multiple centers of China. The demographic data , clinical symptoms/signs and psychological assessment data including Zung self-rating anxiety scale (SAS), Zung self-rating depression scale (SDS) and the Pittsburgh Sleep Quality Index questionnaire (PSQI) were collected using questionnaires. Mann-Whitney U test and t test was used in independent groups for parametric variables, whereas the Spearman correlation analysis and multiple stepwise regression analysis were used to assess correlation between parametric variables.
Results:
683 AS patients by the revised New York criteria for AS and 697 age-, sex-, education-matched healthy controls were enrolled in the study.(1) Compared with healthy controls, AS patients suffered from more severe psychological disorders and sleep disturbance（P<0.001）, and the prevalence rate of comorbidity of anxiety-depression-sleep disorders was significantly higher (32.3%vs. 2.4%, p<0.001) . (2) Spearman rank correlation analysis found the following variables to be significantly associated with the SAS score: disease duration, morning stiffness and duration, overall pain, back pain, BASDAI, BASFI, SDS score and all components of the PSQI score positively and years of education negatively (P<0.05). The SDS score were significantly associated with degree and duration of morning stiffness, overall pain, back pain, BASDAI, BASFI, SAS and all components of the PSQI score positively, and years of education negatively(P<0.05). (3) In multiple regression analysis, SAS and SDS contributed most to each other, with standardized coefficients of 0.674 and 0.598 respectively. Meanwhile SAS (P =0.000) and SDS (P =0.031) contributed significantly to sleep disorder.
Conclusion:
A large number of AS patients were reported to have anxiety, depression, sleep disturbance. Various psychological abnormalities factors influence one another, there is anxiety-depression-sleep disorders comorbidity phenomenon. Psychological abnormalities factors associated with disease activity in AS patients, there was physical-psychological comorbidity phenomenon.
Disclosure:
M. Yang,
None;
Y. Jiang,
None;
Z. Lin,
None;
Z. Liao,
None;
Q. Li,
None;
Y. Zhang,
None;
J. Gu,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/psychological-status-correlates-of-disease-activity-and-sleep-quality-in-patients-with-ankylosing-spondylitis-a-case-control/