Abstracts tagged "Anxiety"

Abstract Number: 0953 • ACR Convergence 2025
NMDAR Autoantibody-Induced Neuronal Damage in the Amygdala Mediates Mood and Anxiety Disorders in a Model of Neuropsychiatric Lupus
Rachel Weissman-Tsukamoto¹, Bruce Volpe¹, Zaide Ibic¹, Kaitlin Carroll², An Vo¹, Czeslawa Kowal¹ and Betty Diamond³, ¹Feinstein Institute of Molecular Medicine, Manhasset, NY, ²Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, ³The Feinstein Institutes for Medical Research, Manhasset, NY
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a multisystem autoimmune disease characterized by aberrant production of autoantibodies and chronic inflammation. Up to 80% of individuals with…
Abstract Number: 0935 • ACR Convergence 2025
Oral Antibiotic Treatment Reduces Anxiety in a Murine Model of Neuropsychiatric Manifestations of Systemic Lupus Erythematosus
Cecilia Stumpf¹, Brianna Thompson², Vanessa Manada De Lobos² and Carla Marie Cuda³, ¹Northwestern University, Elmhurst, IL, ²Northwestern University, Chicago, ³Northwestern University, Chicago, IL
Background/Purpose: Unclear mechanisms underlying diffuse NPSLE (anxiety, cognitive dysfunction) lead to the devastating impact of this disease on patients’ health-related quality-of-life. Dysbiosis of gut microbiota…
Abstract Number: 0714 • ACR Convergence 2025
Factors Associated With Depression And Anxiety In ANCA-Associated Vasculitis Patients: Data From The Almenara Vasculitis Cohort
Alvaro Oyarce-Calderón¹, Allison Figueroa-Sánchez², Leonor León-Yaurimucha², Rocío Gamboa-Cárdenas³, Zoila Rodríguez-Bellido⁴, Risto Perich-Campos⁵, Graciela Alarcón⁶, Manuel Ugarte-Gil⁷ and Victor Pimentel-Quiroz⁸, ¹Hospital Nacional Guillermo Almenara Irigoyen, San Miguel, Lima, Peru, ²Universidad Científica del Sur, Lima, Peru, ³Universidad Científica del Sur, Lima, Peru, ⁴Hospital Nacional Guillermo Almenara Irigoyen; Universidad Nacional Mayor de San Marcos, Lima, Peru, ⁵Hospital Nacional Guillermo Almenara Irigoyen; Universidad Nacional Mayor de San Marcos, La Molina, Peru, ⁶The University of Alabama at Birmingham, Oakland, CA, ⁷Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas, Universidad Científica del Sur, Lima, Peru; Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru, Lima, Peru, ⁸Universidad Científica del Sur, San Isidro, Peru
Background/Purpose: Depression and anxiety symptoms have been reported in 28% of patients suffering from vasculitides. However, in patients with ANCA-associated vasculitis (AAV), their frequency and…
Abstract Number: 0365 • ACR Convergence 2025
Clinical Characteristics and Psychosocial Outcomes of Patients with UCTD Compared to SLE
Caroline Siegel¹, Yongjay Kim², Lucy Masto³, Neha Nagpal¹, Amaya Smole⁴, Dongmei Sun¹, Haley Slosberg¹, Margaret Minett⁵, Joann Vega¹, Deanna Jannat-Khah¹, Jane Salmon¹, Michael Lockshin⁶, Lisa Sammaritano¹ and Medha Barbhaiya¹, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, Englewood Cliffs, NJ, ³Hospital for Special Surgery, San Francisco, CA, ⁴Hospital for Special Surgery, Brooklyn, NY, ⁵Hospital for Special Surgery, New York, ⁶Hospital for Special Surgery, Weill Cornell Medicine, New York, NY
Background/Purpose: While UCTD is considered less clinically severe than SLE, our prior qualitative study reported that patients with UCTD experience significant psychosocial challenges (J Clin…
Abstract Number: 0225 • ACR Convergence 2025
Positive anxiety, depression and/or fibromyalgia screening on validated MDHAQ indices is seen in 30-50% of routine care patients with all rheumatic diagnoses
Juan Schmukler¹, Tengfei Li² and Theodore Pincus¹, ¹Rush University Medical Center, Chicago, IL, ²Rush, chicago, IL
Background/Purpose: Comorbid anxiety (ANX), depression (DEP), and fibromyalgia(FM) are reported as more common in patients with rheumatoid arthritis (RA) and other rheumatic diagnoses than in…
Abstract Number: 2557 • ACR Convergence 2025
Relationship Between Sleep Quality and Psychiatric Symptoms in Autoimmune Rheumatic Diseases
Karen Yaresi Ramos-Reza¹, Maria Eugenia Corral-Trujillo², Eva Abigaid Galindo-Calvillo¹, Joselyn Aracely Alvarez Meza¹, Fatima Adriana Marin.Muñoz¹, Santiago S. Heredia-Gonzalez¹, Laura Patricia Gallegos-Gloria¹, Norberto Luna-Mireles¹, Estefania Escamilla-Barrientos¹, Alicia Abigail Treviño-Arreola¹, Fatima Humphrey-Escamilla¹, Jesus Alberto Cardenas-de la Garza³, Miguel Villarreal-Alarcón⁴, Ivan de Jesús Hernandez-Galarza¹ and Dionicio A. Galarza-Delgado⁵, ¹Rheumatology Service, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo Leon, Mexico, ²Universidad Autónoma de Nuevo León, Rheumatology Service, Hospital Universitario "Dr. José Eleuterio González", Monterrey, Nuevo León, México., Monterrey, Nuevo Leon, Mexico, ³Rheumatology Service, University Hospital “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, México, Monterrey, Mexico, ⁴Hospital Universitario UANL, Monterrey, Nuevo León, Mexico, ⁵Rheumatology Service, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico
Background/Purpose: Autoimmune Rheumatic Diseases (ARDs) commonly present with psychiatric symptoms such as chronic fatigue, depression, and anxiety, and often linked to poor sleep quality. Prolonged…
Abstract Number: 0197 • ACR Convergence 2025
Rheumatoid arthritis (RA) patients who screen positive for anxiety, depression, and/or fibromyalgia are more likely to report problems with sleeping, memory, and/or social activities than to have an abnormal rheumatoid factor or ACPA
Theodore Pincus¹, Juan Schmukler¹ and Tengfei Li², ¹Rush University Medical Center, Chicago, IL, ²Rush, chicago, IL
Background/Purpose: A symptom checklist and screening indices for anxiety (ANX), depression (DEP), and/or fibromyalgia (FM) on patient questionnaires such as a multidimensional health assessment questionnaire…
Abstract Number: 2144 • ACR Convergence 2025
The Association Between Age at Diagnosis and Health-Related Quality of Life in ANCA-Associated Vasculitis
Jessica Bloom¹, Kaci Pickett-Nairne², Lori Silveira¹, Cristina Burroughs³, Katrina Bargender⁴, Amy Bolton⁴, Christine Yeung⁴, Jennifer Gordon⁵, Peter Merkel⁶ and Karen James⁷, ¹University of Colorado, Aurora, CO, ²University of Colorado, Denver, ³University of South Florida, Tampa, FL, ⁴Vasculitis Patient-Powered Research Network, Philadelphia, PA, ⁵Vasculitis Foundation, Kansas City, MO, ⁶University of Pennsylvania, Philadelphia, PA, ⁷University of Utah, Salt Lake City, UT
Background/Purpose: ANCA-associated vasculitis (AAV) is a chronic autoimmune condition that significantly impacts patients’ quality of life. It is unknown whether this impact varies based on…
Abstract Number: 2040 • ACR Convergence 2025
Steroid Psychosis and Neuropsychiatric Symptoms induced by Corticosteroid Injection in Rheumatology Patients
Morvarid Kavosh¹, Virva Walkington¹, Jigisha Rakholiya¹, Krystle Tapia², Maheswari Muruganandam¹, N. Suzanne Emil¹, Frank O'Sullivan³ and Wilmer Sibbitt¹, ¹University of New Mexico, Albuquerque, NM, ²University of New Mexico Hospital, Albuquerque, NM, ³University of New Mexico, Albuquerque
Background/Purpose: Musculoskeletal (MS) corticosteroid (CS) injections are commonly used for joint inflammation with a perceived low risk of systemic toxicity, including hyperglycemia and adrenal suppression.…
Abstract Number: 1688 • ACR Convergence 2025
Impact of Stress, Anxiety, and Depression on Fatigue as moderated by Resilience and Exposure to Trauma in Rheumatology Patients
Akhila Veeravalli¹, Sankeerthana gajjala² and Sarath Chandra Mouli Veeravalli³, ¹Department of Rheumatology, KIMS Hospitals, Secuderabad, India, Hyderabad, Telangana, India, ²KIMS Hospitals, Secunderabad, India, Hyderabad, Telangana, India, ³Dept. of Rheumatology and Clinical Immunology, KIMS Hospitals, Secunderabad, India, Hyderabad, Telangana, India
Background/Purpose: This study aimed to examine the impact of psychological distress—specifically stress, anxiety, and depression—on fatigue in rheumatology patients, and explored how this relationship is…
Abstract Number: 1660 • ACR Convergence 2025
Digital Psychological Support for Inflammatory Rheumatic Diseases: A Randomized Clinical Trial
Johannes Knitza¹, Julia Kraus², Martin Krusche³, Isabell Haase³, Philipp Klemm⁴, Axel Hueber⁵, Pfeil Alexander⁶, Ulrich Drott⁷, Sebastian Kuhn⁸ and Jan Philipp Klein⁹, ¹Institute for Digital Medicine, University Hospital Gießen-Marburg, Philipps University, Marburg, Germany, ²Vila Health, Berlin, Germany, ³Division of Rheumatology and Systemic Inflammatory Diseases, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁴Department of Rheumatology and Clinical Immunology Center, JLU Giessen, Campus Kerckhoff, Bad Nauheim, Germany, Bad Nauheim, Germany, ⁵Klinikum Nuernberg, Nuernberg, Germany, ⁶Department of Internal Medicine III, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ⁷Deutsches Endokrinologisches Versorgungszentrum, Frankfurt, Germany, ⁸Institute for Digital Medicine, University Hospital of Giessen and Marburg, Philipps University Marburg, Marburg, Germany, ⁹Department of Psychiatry, Psychosomatics and Psychotherapy, University of Lübeck, Lübeck, Germany
Background/Purpose: Patients with inflammatory rheumatic diseases (IRDs) frequently experience psychological distress, however access to psychological support remains limited. The aim of this trial (DRKS identifier:…
Abstract Number: 1648 • ACR Convergence 2025
Predicting Worse Disease Activity, QOL, and Progression to Advanced Therapies at 12 and 24 months in Early RA: Results from the Canadian Early Arthritis Cohort (CATCH)
Susan J. Bartlett¹, Marie-France Valois², Clifton Bingham³, Janet Pope⁴, Hugues Allard-Chamard⁵, Louis Bessette⁶, Gilles Boire⁷, Carol Hitchon⁸, Glen Hazlewood⁹, Bindee Kuriya¹⁰, Carter Thorne¹¹ and Vivian Bykerk¹², ¹McGill University, Beaconsfield, QC, Canada, ²McGill University, Pointe-Claire, QC, Canada, ³Johns Hopkins University, Baltimore, MD, ⁴University of Western Ontario, London, ON, Canada, ⁵Université de Sherbrooke, Sherbrooke, Canada, ⁶Centre de l'Ostéoporose et de Rhumatologie de Québec, Quebec, QC, Canada, ⁷Retired, Sherbrooke, QC, Canada, ⁸University of Manitoba, Winnipeg, MB, Canada, ⁹University of Calgary, Calgary, AB, Canada, ¹⁰University of Toronto - Toronto, Toronto, ON, Canada, ¹¹Southlake Regional Health Centre, Newmarket, ON, Canada, ¹²Hospital for Special Surgery, New York, NY
Background/Purpose: Pain, fatigue, and emotional distress are common in new RA patients. It is unclear whether co-occurring symptoms predict worse outcomes and progression to advanced therapies…
Abstract Number: 1381 • ACR Convergence 2025
Self-Reported and Actigraphic Sleep and Circadian Rhythm Disruptions in Patients with Sjögren’s Disease: Associations with Disease Activity and Patient-Reported Outcomes
Caterina Di Pede¹, Alessandro Colitta², Marco Di Galante³, Simone Bruno⁴, Stefano Donati¹, Beatrice Dei¹, Giovanni Fulvio¹, Gaetano La Rocca⁵, Rosaria Talarico⁶, Marta Mosca¹, Chiara Baldini⁷ and Ugo Faraguna⁴, ¹Rheumatology Unit, University of Pisa, Pisa, Toscana, Italy, ²Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Toscana, Italy, ³Sleepacta srl, Montacchiello, Pisa, Italy, Pisa, Toscana, Italy, ⁴Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa., Pisa, Toscana, Italy, ⁵University of Pisa, Rheumatology Unit, Pisa, Pisa, Italy, ⁶Azienda Ospedaliero Universitaria Pisana, Pisa, Pisa, Italy, ⁷University of Pisa, Pisa, Pisa, Italy
Background/Purpose: Patients with Sjögren’s Disease (SjD) frequently report debilitating symptoms such as pain, fatigue, and dryness, significantly impacting health-related quality of life. Although sleep disturbances…
Abstract Number: 1380 • ACR Convergence 2025
Phenotyping Neuropathic Pain in Sjögren’s Disease: A Cluster-Based Approach
Beatrice Dei¹, Stefano Donati¹, Gaetano La Rocca², Giovanni Fulvio¹, Federico Fattorini¹, Antonello Sulis¹, Michele Moretti¹, Elena Elefante¹, Francesco Ferro³, Giulia Ricci⁴, Marta Mosca⁵ and Chiara Baldini⁵, ¹Rheumatology Unit, University of Pisa, Pisa, Toscana, Italy, ²University of Pisa, Rheumatology Unit, Pisa, Pisa, Italy, ³Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Pisa, Italy, ⁴Neurology Unit, University of Pisa, Pisa, Toscana, Italy, ⁵University of Pisa, Pisa, Pisa, Italy
Background/Purpose: Neuropathic pain (NeP) is increasingly recognized as a relevant symptom domain in primary Sjögren’s disease (SjD), contributing to the disease burden beyond glandular involvement.…
Abstract Number: 1281 • ACR Convergence 2025
Ethnic Disparities in Mental Health Screening, Diagnoses, and Outcomes in Patients with Childhood-Onset Systemic Lupus Erythematosus
Alicia Tran¹, Indrani Das², Zhaoyu Ding³, Daniela Dominguez⁴, Sefi Kronenberg⁵, Lawrence Ng⁶, Alene Toulany¹, Gwyneth Zai⁷, Deborah Levy¹, Andrea Knight⁸ and Linda Hiraki¹, ¹The Hospital for Sick Children, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³SickKids Research Institute, Toronto, ON, Canada, ⁴The Hospital for Sick Children, Toronto, Canada, ⁵Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada, ⁶The Hospital for Sick Children, Toronto, Canada, Toronto, ON, Canada, ⁷Centre for Addiction & Mental Health, Toronto, ON, Canada, ⁸Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Patients with childhood-onset systemic lupus erythematosus (cSLE) face higher risks of depression and anxiety compared to healthy peers. In 2022, standardized mental health (MH)…

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