Background/Purpose:
The prevalence of Metabolic Syndrome (MetS) tends to be high among rheumatic patients, and cardiovascular disease is the leading cause of death in these conditions. The aim of this study is to determine the prevalence of MetS in Takayasu Arteritis patients (TA) and its association with risk factors and adipokines levels.
Methods:
A cross sectional study was conducted in 45 consecutive TA women with 47 age- and body mass index (BMI)-matched healthy controls.
Results: The prevalence of MetS (IDF/AHA criteria) was higher in TA compared to controls (33.34 vs. 8.51%, p=0.003). TA patients had higher frequency hypertension (p< 0.001), dyslipidemia (p=0.001), insulin (p=0.021), HOMA-IR (p=0.024), apoliprotein E (p=0.029), resistin (p=0.018) and CRP (p<0.001) compared to healthy subjects, with similar levels of adiponectin and PAI-1 (p>0.05). Further analysis of TA patients with and without MetS revealed a higher frequency of overweightness/obesity (66.66 vs. 26.66%, p=0.022), Framingham score ≥1 (p=0.032), and lower adiponectin levels (20.37±21.16 vs. 38.64±22.62ug/ml, p=0.022) in the former group. No differences were found regarding disease duration, activity, glucocorticoid use, resistin and PAI-1 levels in these two groups of TA patients (p>0.05).
Conclusion:
A high prevalence of MetS was observed in TA patients and this comorbidity seems to identify a subgroup of overweight/obese patients with high cardiovascular risk without a significant association with disease status. Further longitudinal studies are necessary to observe the impact of controlling this modifiable risk factor in the quality of life and survival of TA patients.
Disclosure:
T. Silva,
None;
M. Levy-Neto,
None;
R. M. R. Pereira,
CNPQ #300559/2009-7,
2,
Federico Fondation,
2;
E. Bonfa,
None.
« Back to 2013 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/high-prevalence-of-metabolic-syndrome-in-takayasu-arteritis-an-increased-cardiovascular-risk-and-lower-adiponectin-serum-levels/