Trends and Outcomes of Hospitalized Patients with Idiopathic Inflammatory Myopathy and Venous Thromboembolism: A Nationwide Inpatient Sample Analysis from US (2016-2019)

Haseeb Chaudhary¹, Biraj Shrestha², Sarah Abi Doumeth³ and Maya Mattar⁴, ¹Case Western Reserve University, Westlake, OH, ²Tower Health System, Reading, PA, ³Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, ⁴Louis Stokes VA Medical Center, Cleveland, OH

Meeting: ACR Convergence 2023

Keywords: Cost-Effectiveness, Epidemiology, Health Services Research, Mortality, Myositis

Session Information

Date: Sunday, November 12, 2023

Title: (0283–0307) Muscle Biology, Myositis & Myopathies – Basic & Clinical Science Poster I

Session Type: Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Recent evidence suggests increased prevalence of venous thromboembolism (VTE) in patients with idiopathic inflammatory myopathies (IIM). The literature on the clinical implications of VTE among IIM patients remains scarce. We evaluated the recent trends in the mortality rates, length of stay (LOS), and cost of care (COC) of hospitalized patients with IIM with or without VTEs.

Methods: The 2016-2019 Nationwide Inpatient Sample (NIS) database was accessed to identify all adult (18 years and older) IIM patients hospitalized with or without VTE using ICD-10 codes. Baseline demographic characteristics and in-hospital outcomes were compared between the two groups. A multivariate logistic regression analysis was used to calculate the adjusted odds ratio (OR).

Results: The total number of hospitalized patients with IIM was 15,165 of whom 715 (4.71%) had VTE. There was no significant difference in the baseline characteristics between the two groups concerning age, gender, race, co-morbidities and hospital setting as shown in Table 1.0 (a). The mean age was 64.80 years (62.29-67.71) in patients with VTE with a male predominance (58%). The inpatient mortality rate in patients with VTE was significantly higher than those without (9.09% vs. 3.98%, p< 0.003), with an adjusted OR 2.04 (95% CI 1.09-3.81), Table 1.0 (b). The highest rate of VTE was observed in patients with dermatomyositis, 8.93%, amongst all subtypes of IIM. The mean LOS in patients with VTE was 13.10 days (10.96-15.24) vs 7.93 days (7.55-8.31) in the comparison group (p< 0.001). The mean COC was significantly higher in patients with VTE than those without, $36,733.67 vs $21,441.79 (p< 0.001).

Conclusion: VTE in patients admitted with IIM was associated with significantly higher inpatient mortality, COC and increased LOS. These results may signify the need for appropriate VTE preventive strategies in IIM to improve patient outcomes and impact on the healthcare system.

Table 1.0 (a) Baseline Characteristics, Mortality and Cost utilizations of inflammatory myositis admitted with or without VTE.

Table 1.0 (b) – Unadjusted and adjusted odds ratios for risk of mortality in inflammatory myositis with VTE.

Disclosures: H. Chaudhary: None; B. Shrestha: None; S. Abi Doumeth: None; M. Mattar: None.

To cite this abstract in AMA style:

Chaudhary H, Shrestha B, Abi Doumeth S, Mattar M. Trends and Outcomes of Hospitalized Patients with Idiopathic Inflammatory Myopathy and Venous Thromboembolism: A Nationwide Inpatient Sample Analysis from US (2016-2019) [abstract]. Arthritis Rheumatol. 2023; 75 (suppl 9). https://acrabstracts.org/abstract/trends-and-outcomes-of-hospitalized-patients-with-idiopathic-inflammatory-myopathy-and-venous-thromboembolism-a-nationwide-inpatient-sample-analysis-from-us-2016-2019/. Accessed .

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