Background/Purpose:

Periostin (POSTN) is a secreted vitamin K-dependent (Gla-containing) protein produced by osteoblasts and chondrocytes. The aim of this study was to investigate the relationships between serum POSTN and both prevalent and incident knee osteoarthritis in women.  

Methods: We investigated 753 women (mean age: 62.7 ± 11.2 yr) from the OFELY (Os des Femmes de Lyon) cohort, 19.3 % being premenopausal. Knee radiographs were performed and scored according to Kellgren & Lawrence at the ninth annual follow-up (baseline for this analysis) and 4 years later. Progression of knee OA was defined as an increase of the KL score ≥ 1 during the 4 years follow-up. Evaluation of the spine (X-rays), hip (self-reported) and hand OA (clinical exam) have been performed at the same visit. Serum POSTN was measured at baseline by ELISA (USCNK, China).

Results:

Serum POSTN was significantly lower in the 110 women with a KL score ≥ 2 at baseline, compared to the 481 controls with a KL score < 2 (1118.9 ± 307 ng/ml vs 1182.3 ± 292 ng/ml, p = 0.018 after adjustment for age). During the 4 year follow-up, 181 women had a radiological progression in their knee OA. Baseline POSTN levels were significantly lower in progressors than in non progressors (1140 ± 296 vs 1182 ± 294 ng/ml, p = 0.039 after adjustment for age and for the presence of prevalent knee, spine, hip and hand OA). For each increase of one POSTN quartile, the risk of progression decreased by 0.82 (IC: 0.69-0.98, p = 0.034) after adjustment for age and for OA at the other anatomical sites.

Conclusion: We showed for the first time that serum POSTN is associated with prevalence and progression of knee OA in women. This biomarker may be of interest to study OA pathophysiology.

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« Back to 2013 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/serum-periostin-is-associated-with-prevalent-knee-osteoarthritis-and-predicts-disease-progression-in-women-the-ofely-study/