Association between Hyperuricemia and Metabolic Syndrome with or without Obesity: Results from the 2016 Korea National Health and Nutrition Examination Survey

In Young Kim¹, Yeong Hee Eun¹, Eun-Jung Park², Joong Kyong Ahn³, Chan Hong Jeon⁴, Jaejoon Lee⁵, Hoon-Suk Cha¹, Eun-Mi Koh⁵, Kyungdo Han⁶ and Hyungjin Kim¹, ¹Department of Medicine, Division of Rheumatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), ²Department of Medicine, Division of Rheumatology, National Medical Center, Seoul, Korea, Republic of (South), ³Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), ⁴Department of Medicine, Division of Rheumatology, Soonchunhyang University College of Medicine, Bucheon, Korea, Republic of (South), ⁵Department of Medicine,Division of Rheumatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), ⁶Department of Biostatistics, Catholic University of Korea, Seoul, Korea, Republic of (South)

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: hyperuricemia, metabolic syndrome and obesity

Session Information

Date: Monday, October 22, 2018

Title: Epidemiology and Public Health Poster II: Gout, Ankylosing Spondylitis, Osteoarthritis, Osteoporosis, Pain, and Function

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Hyperuricemia is increasing worldwide, and is emerging as a potential biomarker and predictor for metabolic syndrome and related complications. We aimed this study to investigate the association between hyperuricemia and metabolic syndrome with or without obesity.

Methods: We performed multivariate logistic regression analyses using the 2016 Korea National Health and Nutrition Examination Survey (KNHANES) data collected in a representative sample of Korean adults (defined by age ≥ 20 years). Hyperuricemia was defined by serum uric acid level ≥7.0 mg/dl for men and ≥6.0 mg/dl for women. Obesity was based on body mass index (BMI) ≥ 25 kg/m².

Results: Among a total of 5,591 Korean adult participants, 685 (12.3%) individuals were classified as having hyperuricemia. Hyperuricemia was significantly associated with metabolic syndrome in both men (Odd ratio (OR) = 1.74, 95% CI: 1.29-2.34) and women (OR = 2.47, 95% CI: 1.55-3.93) after adjustments for age, sex, smoking, alcohol, exercise, BMI and estimated glomerular filtration rate (eGFR). Obesity was also independently related to hyperuricemia in both sex (OR = 1.70, 95% CI: 1.31-2.19 in men, OR = 3.73, 95% CI: 2.57-5.41 in women). Among the components of metabolic syndrome, elevated blood pressure, elevated triglyceride and reduced high-density lipoprotein (HLD)-cholesterol in men, and increased waist circumference, hyperglycemia, elevated triglyceride in women were risk factors for hyperuricemia. In subgroup analyses, individuals who had metabolic syndrome with obesity were at the highest risk of hyperuricemia, followed by those with metabolic syndrome without obesity in overall population (OR = 3.91, 95% CI: 3.00-5.09, OR = 3.21, 95% CI: 2.28-4.52, respectively). In population with metabolic syndrome, the presence of obesity posed higher risk for hyperuricemia in women compared with men (OR = 7.24, 95% CI: 4.56-11.50 versus OR = 2.90, 95% CI: 2.12-3.96).

Conclusion: Our results indicate that hyperuricemia is independently associated with metabolic syndrome and obesity in both sex. The effect of obesity in increasing the risk of hyperuricemia was more pronounced in women compared to men.

Disclosure: I. Y. Kim, None; Y. H. Eun, None; E. J. Park, None; J. K. Ahn, None; C. H. Jeon, None; J. Lee, None; H. S. Cha, None; E. M. Koh, None; K. Han, None; H. Kim, None.

To cite this abstract in AMA style:

Kim IY, Eun YH, Park EJ, Ahn JK, Jeon CH, Lee J, Cha HS, Koh EM, Han K, Kim H. Association between Hyperuricemia and Metabolic Syndrome with or without Obesity: Results from the 2016 Korea National Health and Nutrition Examination Survey [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/association-between-hyperuricemia-and-metabolic-syndrome-with-or-without-obesity-results-from-the-2016-korea-national-health-and-nutrition-examination-survey/. Accessed .

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