ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2785

Association of Anti-Glutamate Receptor Subunit NR2 Antibody and Psychiatric Disorder in Patients with Primary Sjögren Syndrome

Yoshiyuki Arinuma1,2, Yuko Sakuma3, Eisuke Ogawa2, Tatsuhiko Wada4, Tatsuo Nagai2, Sumiaki Tanaka2 and Shunsei Hirohata2, 1Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, 2Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 3Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 4Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: , , ,

Session Information

Date: Tuesday, November 10, 2015

Title: Sjögren's Syndrome: Translational Insights into Sjögren's Syndrome

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:
Sjögren syndrome (SjS) is one of the autoimmune disease characterized by the
production of autoantibodies. Patients with SjS frequently observe psychiatric manifestation
such as depression, anxiety and cognitive dysfunction as is often seen in
patients with systemic lupus erythematosus (SLE). Anti-glutamate receptor
subunit NR2 antibodies (anti-NR2) is one of the pathogenic autoantibodies related
to psychiatric disorder (PD) in patients with SLE. However, anti-NR2 in patients
with SjS has not been clarified. The aim of this study is to investigate the
association of anti-NR2 and PD in patients with primary SjS (pSjS).

Methods:
We examined 35 patients with pSjS, 17 patients with rheumatic diseases other
than SLE or SjS as disease control (DC) and 36 healthy individuals (HC).
Anti-NR2 in serum were measured by ELISA.

Results:
The level of anti-NR2 in serum was significantly elevated in patients with
pSjS (47.3±69.4U/ml), compared to those with DC (14.0±16.6, p=0.0043) or HC
(16.8±9.6, p=0.0226). In pSjS patients with PD, the serum anti-NR2 level was
significantly higher than that in patients without PD (p=0.0003). Also, the
positivity of anti-NR2 in serum from patients with pSjS was found to be a significant risk factor for PD in pSjS patients
(OR 38.0, 95%CI 5.5-789.3, p=0.0018) by logistic regression analysis.

Conclusion:
Anti-NR2 are significantly associated
with PD in patients with pSjS.

Disclosure: Y. Arinuma, None; Y. Sakuma, None; E. Ogawa, None; T. Wada, None; T. Nagai, None; S. Tanaka, None; S. Hirohata, None.

To cite this abstract in AMA style:

Arinuma Y, Sakuma Y, Ogawa E, Wada T, Nagai T, Tanaka S, Hirohata S. Association of Anti-Glutamate Receptor Subunit NR2 Antibody and Psychiatric Disorder in Patients with Primary Sjögren Syndrome [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/association-of-anti-glutamate-receptor-subunit-nr2-antibody-and-psychiatric-disorder-in-patients-with-primary-sjogren-syndrome/. Accessed .

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