ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 398

Clinical and Serological Profile of Children with Positive SSA-Ro/SSB-La Antibodies

Juan G. Ovalles-Bonilla1, Juan C. Nieto1, Francisco Javier López Longo1, Julia Martínez-Barrio2, Iustina Janta1, Esperanza Naredo1, Carlos M. Gonzalez1, Michelle Hinojosa1, Natalia Bello1, Belen Serrano1, Carmen Mata1, Claudia Sáenz Tenorio1, Diana C. Hernández1, Lara Valor1, Indalecio Monteagudo1 and Luis Carreño1, 1Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 2Servicio de Reumatologia, Hospital General Universitario Gregorio Marañón, Madrid, Spain

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: , ,

Session Information

Date: Sunday, November 8, 2015

Title: Pediatric Rheumatology – Clinical and Therapeutic Aspects Poster I: Lupus, Scleroderma, JDMS

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Several studies have shown the relationship between anti-SSA-Ro/SSB-La antibodies and Systemic Lupus Erythematosus (SLE), Sjögren Syndrome (SS) and other autoimmune diseases in adult population. However, the expression of these autoantibodies and clinical correlation in juvenile patients is poorly described. To characterize the clinical and serological profile and primary rheumatic diseases in pediatric patients with positive anti-SSA-Ro and/or anti-SSB-La antibodies.

Methods: The data was obtained from a long term prospective cohort of patients under age 18 diagnosed with rheumatic diseases in a tertiary hospital in Spain. Demographic, clinical, and laboratory data were collected from 1986 to 2010. Patients were divided into 2 groups: anti-SSA-Ro/SSB-La positive and anti-SSA-Ro/SSB-La negative.

Results: A total of 187 patients were tested for anti Extractable Nuclear Antigens (ENA), with a following mean time of 11 years. Mean age at disease onset was 12.6 years and 77% were female. Fifty-four (28.9%) anti-SSA-Ro/SSB-La positive subjects were compared against 133 (71.1%) anti-SSA-Ro/SSB-La negative subjects. Among positive cases, 13 (24.1%) patients were double-positive for anti-SSA-Ro and anti-SSB-La, 51 (94.4%) were positive for anti-SSA-Ro and 3 (5.5%) were single-positive for anti-SSB-La. The anti-SSA-Ro/SSB-La antibodies were found less frequently (p=0.003) in the overlapping syndromes, and more frequently in SLE (p=0.007). In addition rheumatoid factor (p<0.001), anti-Sm (p<0.001) and anti-RNP (p<0.001) were frequently co-expressed with anti-SSA-Ro/SSB-La antibodies. Finally the anti-SSA-Ro/SSB-La positive group presented more hematological and skin manifestations than the negative group (p<0.05).

Conclusion: Similarly to adults, we observed a relationship between anti-SSA-Ro/SSB-La antibodies and SLE in pediatric patients. However a low proportion of childhood primary SS exists in our anti-SSA-Ro/SSB-La positive cases. This could be explained by underdiagnoses related to the atypical clinical presentation of SS in pediatric population. Single-positive anti-SSB-La patients are uncommon, the clinical significance of this serological result remains uncertain in children.

References: Rheumatol Int (2014) 34:1123–1127.

Disclosure: J. G. Ovalles-Bonilla, None; J. C. Nieto, None; F. J. López Longo, None; J. Martínez-Barrio, None; I. Janta, None; E. Naredo, None; C. M. Gonzalez, None; M. Hinojosa, None; N. Bello, None; B. Serrano, None; C. Mata, None; C. Sáenz Tenorio, None; D. C. Hernández, None; L. Valor, None; I. Monteagudo, None; L. Carreño, None.

To cite this abstract in AMA style:

Ovalles-Bonilla JG, Nieto JC, López Longo FJ, Martínez-Barrio J, Janta I, Naredo E, Gonzalez CM, Hinojosa M, Bello N, Serrano B, Mata C, Sáenz Tenorio C, Hernández DC, Valor L, Monteagudo I, Carreño L. Clinical and Serological Profile of Children with Positive SSA-Ro/SSB-La Antibodies [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/clinical-and-serological-profile-of-children-with-positive-ssa-rossb-la-antibodies/. Accessed .

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